Carnosine treatment in combination with ACE inhibition in diabetic rats.

Peters V, Riedl E, Braunagel M, Höger S, Hauske S, Pfister F, Zschocke J, Lanthaler B, Benck U, Hammes HP, Krämer BK, Schmitt CP, Yard BA, Köppel H

Regulatory peptides16 Sept 2014Cited by 31 (Europe PMC)

PMID25234296DOI10.1016/j.regpep.2014.09.005PepBankPUB-25234296

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, carnosine normalized increased renal CN1 protein abundance versus untreated STZ rats.
In plain wordsIn diabetic rats, carnosine normalized elevated kidney CN1 protein compared with untreated rats.
Peptide
L-carnosine
Outcome
DecreaseRenal CN1 abundance
Study
ratsn: not reported in source
streptozotocin diabetes with unilateral nephrectomy
Comparator
non-treated STZ rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · 24 weeksAs given in this study (rats).
Source sentences
Summary
Carnosine treatment normalized CN1 abundance
2 context sentences(design, population, supporting numbers)
Summary · context
Male Sprague-Dawley rats were injected i.v. with streptozotocin (STZ) to induce diabetes.
Summary · context
After 4 weeks, rats were unilaterally nephrectomized and randomized for 24 weeks of treatment with carnosine, lisinopril or both.
Report a problemFND-2523429601
02AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, carnosine reduced glucosuria versus untreated STZ rats.
In plain wordsIn diabetic rats, carnosine reduced urine glucose compared with untreated rats.
Peptide
L-carnosine
Outcome
DecreaseGlucosuria
Study
ratsn: not reported in source
streptozotocin diabetes with unilateral nephrectomy
Comparator
non-treated STZ rats
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated · 24 weeksAs given in this study (rats).
Source sentences
Summary
Carnosine treatment normalized CN1 abundance and reduced glucosuria, blood concentrations of glycosylated hemoglobin (HbA1c), carboxyl-methyl lysine (CML), N-acetylglucosamine (GlcNac; all p<0.05 vs. non-treated STZ rats)
2 context sentences(design, population, supporting numbers)
Summary · context
Male Sprague-Dawley rats were injected i.v. with streptozotocin (STZ) to induce diabetes.
Summary · context
After 4 weeks, rats were unilaterally nephrectomized and randomized for 24 weeks of treatment with carnosine, lisinopril or both.
Report a problemFND-2523429602
03AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, carnosine reduced blood HbA1c versus untreated STZ rats.
In plain wordsIn diabetic rats, carnosine reduced HbA1c compared with untreated rats.
Peptide
L-carnosine
Outcome
DecreaseHbA1c
Study
ratsn: not reported in source
streptozotocin diabetes with unilateral nephrectomy
Comparator
non-treated STZ rats
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated · 24 weeksAs given in this study (rats).
Source sentences
Summary
Carnosine treatment normalized CN1 abundance and reduced glucosuria, blood concentrations of glycosylated hemoglobin (HbA1c), carboxyl-methyl lysine (CML), N-acetylglucosamine (GlcNac; all p<0.05 vs. non-treated STZ rats)
2 context sentences(design, population, supporting numbers)
Summary · context
Male Sprague-Dawley rats were injected i.v. with streptozotocin (STZ) to induce diabetes.
Summary · context
After 4 weeks, rats were unilaterally nephrectomized and randomized for 24 weeks of treatment with carnosine, lisinopril or both.
Report a problemFND-2523429603
04AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, carnosine reduced blood carboxyl-methyl lysine versus untreated STZ rats.
In plain wordsIn diabetic rats, carnosine reduced blood carboxyl-methyl lysine compared with untreated rats.
Peptide
L-carnosine
Outcome
DecreaseBlood carboxyl-methyl lysine
Study
ratsn: not reported in source
streptozotocin diabetes with unilateral nephrectomy
Comparator
non-treated STZ rats
Outcome group
Blood biochemical markers · Metabolic and weight
Studied dose
Dose not stated · 24 weeksAs given in this study (rats).
Source sentences
Summary
Carnosine treatment normalized CN1 abundance and reduced glucosuria, blood concentrations of glycosylated hemoglobin (HbA1c), carboxyl-methyl lysine (CML), N-acetylglucosamine (GlcNac; all p<0.05 vs. non-treated STZ rats)
2 context sentences(design, population, supporting numbers)
Summary · context
Male Sprague-Dawley rats were injected i.v. with streptozotocin (STZ) to induce diabetes.
Summary · context
After 4 weeks, rats were unilaterally nephrectomized and randomized for 24 weeks of treatment with carnosine, lisinopril or both.
Report a problemFND-2523429604
05AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, carnosine reduced blood N-acetylglucosamine versus untreated STZ rats.
In plain wordsIn diabetic rats, carnosine reduced blood N-acetylglucosamine compared with untreated rats.
Peptide
L-carnosine
Outcome
DecreaseBlood N-acetylglucosamine
Study
ratsn: not reported in source
streptozotocin diabetes with unilateral nephrectomy
Comparator
non-treated STZ rats
Outcome group
Blood biochemical markers · Metabolic and weight
Studied dose
Dose not stated · 24 weeksAs given in this study (rats).
Source sentences
Summary
Carnosine treatment normalized CN1 abundance and reduced glucosuria, blood concentrations of glycosylated hemoglobin (HbA1c), carboxyl-methyl lysine (CML), N-acetylglucosamine (GlcNac; all p<0.05 vs. non-treated STZ rats)
2 context sentences(design, population, supporting numbers)
Summary · context
Male Sprague-Dawley rats were injected i.v. with streptozotocin (STZ) to induce diabetes.
Summary · context
After 4 weeks, rats were unilaterally nephrectomized and randomized for 24 weeks of treatment with carnosine, lisinopril or both.
Report a problemFND-2523429605
06AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, carnosine reduced cataract formation versus untreated STZ rats.
In plain wordsIn diabetic rats, carnosine reduced cataract formation compared with untreated rats.
Peptide
L-carnosine
Outcome
DecreaseCataract formation
Study
ratsn: not reported in source
streptozotocin diabetes with unilateral nephrectomy
Comparator
non-treated STZ rats
Outcome group
Vision and retina · Eye
Studied dose
Dose not stated · 24 weeksAs given in this study (rats).
Source sentences
Summary
reduced cataract formation (p<0.05) and urinary albumin excretion (p<0.05), preserved podocyte number (p<0.05) and normalized the increased renal tissue CN1 protein concentration.
2 context sentences(design, population, supporting numbers)
Summary · context
Male Sprague-Dawley rats were injected i.v. with streptozotocin (STZ) to induce diabetes.
Summary · context
After 4 weeks, rats were unilaterally nephrectomized and randomized for 24 weeks of treatment with carnosine, lisinopril or both.
Report a problemFND-2523429606
07AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, carnosine reduced urinary albumin excretion versus untreated STZ rats.
In plain wordsIn diabetic rats, carnosine reduced urinary albumin loss compared with untreated rats.
Peptide
L-carnosine
Outcome
DecreaseUrinary albumin excretion
Study
ratsn: not reported in source
streptozotocin diabetes with unilateral nephrectomy
Comparator
non-treated STZ rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · 24 weeksAs given in this study (rats).
Source sentences
Summary
reduced cataract formation (p<0.05) and urinary albumin excretion (p<0.05), preserved podocyte number (p<0.05) and normalized the increased renal tissue CN1 protein concentration.
2 context sentences(design, population, supporting numbers)
Summary · context
Male Sprague-Dawley rats were injected i.v. with streptozotocin (STZ) to induce diabetes.
Summary · context
After 4 weeks, rats were unilaterally nephrectomized and randomized for 24 weeks of treatment with carnosine, lisinopril or both.
Report a problemFND-2523429607
08AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, carnosine preserved podocyte number versus untreated STZ rats.
In plain wordsIn diabetic rats, carnosine preserved kidney podocyte numbers compared with untreated rats.
Peptide
L-carnosine
Outcome
IncreasePodocyte number
Study
ratsn: not reported in source
streptozotocin diabetes with unilateral nephrectomy
Comparator
non-treated STZ rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · 24 weeksAs given in this study (rats).
Source sentences
Summary
reduced cataract formation (p<0.05) and urinary albumin excretion (p<0.05), preserved podocyte number (p<0.05) and normalized the increased renal tissue CN1 protein concentration.
2 context sentences(design, population, supporting numbers)
Summary · context
Male Sprague-Dawley rats were injected i.v. with streptozotocin (STZ) to induce diabetes.
Summary · context
After 4 weeks, rats were unilaterally nephrectomized and randomized for 24 weeks of treatment with carnosine, lisinopril or both.
Report a problemFND-2523429608
09AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, carnosine reduced albumin excretion less effectively than lisinopril.
In plain wordsIn diabetic rats, carnosine reduced albumin loss less than lisinopril.
Peptide
L-carnosine
Outcome
IncreaseAlbumin excretion versus lisinopril
Study
ratsn: not reported in source
streptozotocin diabetes with unilateral nephrectomy
Comparator
lisinopril
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · 24 weeksAs given in this study (rats).
Source sentences
Summary
Treatment with lisinopril had no effect on HbA1C, glucosuria, cataract formation and CN1 concentration, but reduced albumin excretion rate more effectively than carnosine treatment (p<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Male Sprague-Dawley rats were injected i.v. with streptozotocin (STZ) to induce diabetes.
Summary · context
After 4 weeks, rats were unilaterally nephrectomized and randomized for 24 weeks of treatment with carnosine, lisinopril or both.
Report a problemFND-2523429609

Studies that did not test the peptide alone2

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

10AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, combined carnosine and lisinopril showed no additive effect on podocyte number versus single treatments.
In plain wordsIn diabetic rats, carnosine plus lisinopril gave no added benefit for podocyte numbers compared with single treatments.
Peptide
L-carnosine
Outcome
No significant changeCombination podocyte number
Study
ratsn: not reported in source
streptozotocin diabetes with unilateral nephrectomy
Comparator
single treatments
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
Treatment with both carnosine and lisinopril combined the effects of single treatment, albeit without additive effect on podocyte number or albuminuria.
2 context sentences(design, population, supporting numbers)
Summary · context
Male Sprague-Dawley rats were injected i.v. with streptozotocin (STZ) to induce diabetes.
Summary · context
After 4 weeks, rats were unilaterally nephrectomized and randomized for 24 weeks of treatment with carnosine, lisinopril or both.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2523429610
11AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, combined carnosine and lisinopril showed no additive effect on albuminuria versus single treatments.
In plain wordsIn diabetic rats, carnosine plus lisinopril gave no added benefit for albuminuria compared with single treatments.
Peptide
L-carnosine
Outcome
No significant changeCombination albuminuria
Study
ratsn: not reported in source
streptozotocin diabetes with unilateral nephrectomy
Comparator
single treatments
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
Treatment with both carnosine and lisinopril combined the effects of single treatment, albeit without additive effect on podocyte number or albuminuria.
2 context sentences(design, population, supporting numbers)
Summary · context
Male Sprague-Dawley rats were injected i.v. with streptozotocin (STZ) to induce diabetes.
Summary · context
After 4 weeks, rats were unilaterally nephrectomized and randomized for 24 weeks of treatment with carnosine, lisinopril or both.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2523429611

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Keywords

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