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Study · Animal study (in vivo) · chicken · 2025

14 results

Dietary supplementation with carnosine reduces the prevalence of breast muscle myopathies without altering performance, meat yield or quality in broiler chickens.

Askri A, Martel-Kennes Y, Pouliot E, Saucier L, Alnahhas N

Animal : an international journal of animal bioscience15 Apr 2025Cited by 2 (Europe PMC)

PMID40367889 (opens in a new tab)DOI10.1016/j.animal.2025.101518 (opens in a new tab)PepBankPUB-40367889
Publisher pagePubMedAsk about this study
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Summary

Breast muscle myopathies such as White striping and Wooden breast represent a major challenge for the poultry industry due to the deterioration of breast meat quality induced by these myopathies. Previous research has demonstrated that oxidative stress and subsequent oxidative damage in the Pectoralis major muscle were predisposing factors for the development of breast muscle myopathies. More specifically, research has shown that myopathic muscle content of histidine-containing dipeptides such as carnosine that is well-known for its antioxidant properties was almost entirely depleted, exposing the muscle to oxidative stress and predisposing it to the development of myopathies. The aim of the present study was thus to investigate the effect of dietary carnosine supplementation on growth, meat yield, meat quality and the prevalence of breast muscle myopathies. To achieve this, a total of 1 080 1-day-old male Ross 308 chicks were distributed into two treatment groups in a randomized complete block design with 12 replicates per treatment. The experimental groups included a basal diet and the same basal diet supplemented with 500 mg of carnosine/kg that were fed from d 1 to d 35. The data analysis revealed that apart from a slightly lower (P = 0.03) BW at d 21 in the carnosine group compared to the control, final weight, growth and feed conversion were not influenced by the experimental diet. Similarly, carcass weight, carcass yield, yield of carcass cuts and technological quality traits of breast meat did not differ between groups. However, carnosine supplementation was associated with a reduction of the prevalence of White striping (P < 0.001), Wooden breast (P < 0.001) and the co-occurrence of these two myopathies (P < 0.001). Moreover, carnosine supplementation increased (P < 0.001) the antioxidant potential of breast muscles while malonaldehyde and carbonyl concentrations remained similar in the experimental group relative to the control group. In conclusion, carnosine supplementation provided promising results with regard to breast muscle myopathies. Further research is needed to elucidate the mechanisms underlying the effect of carnosine on these myopathies.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In broiler chickens, carnosine slightly reduced body weight at d 21 versus control.

    In plain wordsIn chickens, carnosine slightly reduced body weight at d 21 compared with the basal diet.

    Peptide
    L-carnosine
    Outcome
    DecreaseBody weight at d 21
    Study

    chickenn = 1,080

    Male Ross 308 broiler chicks
    Comparator
    Basal diet
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    500 mg/kg diet · dietary · d 1 to d 35As given in this study (chicken).

    Source sentences

    Summary
    The data analysis revealed that apart from a slightly lower (P = 0.03) BW at d 21 in the carnosine group compared to the control, final weight, growth and feed conversion were not influenced by the experimental diet.
    2 context sentences
    Summary · context
    To achieve this, a total of 1 080 1-day-old male Ross 308 chicks were distributed into two treatment groups in a randomized complete block design with 12 replicates per treatment.
    Summary · context
    The experimental groups included a basal diet and the same basal diet supplemented with 500 mg of carnosine/kg that were fed from d 1 to d 35.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In broiler chickens, final weight did not differ between carnosine and control diets.

    In plain wordsIn chickens, final weight did not differ between carnosine and basal diets.

    Peptide
    L-carnosine
    Outcome
    No significant changeFinal weight
    Study

    chickenn = 1,080

    Male Ross 308 broiler chicks
    Comparator
    Basal diet
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    500 mg/kg diet · dietary · d 1 to d 35As given in this study (chicken).

    Source sentences

    Summary
    The data analysis revealed that apart from a slightly lower (P = 0.03) BW at d 21 in the carnosine group compared to the control, final weight, growth and feed conversion were not influenced by the experimental diet.
    2 context sentences
    Summary · context
    To achieve this, a total of 1 080 1-day-old male Ross 308 chicks were distributed into two treatment groups in a randomized complete block design with 12 replicates per treatment.
    Summary · context
    The experimental groups included a basal diet and the same basal diet supplemented with 500 mg of carnosine/kg that were fed from d 1 to d 35.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In broiler chickens, growth did not differ between carnosine and control diets.

    In plain wordsIn chickens, growth did not differ between carnosine and basal diets.

    Peptide
    L-carnosine
    Outcome
    No significant changeGrowth
    Study

    chickenn = 1,080

    Male Ross 308 broiler chicks
    Comparator
    Basal diet
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    500 mg/kg diet · dietary · d 1 to d 35As given in this study (chicken).

    Source sentences

    Summary
    The data analysis revealed that apart from a slightly lower (P = 0.03) BW at d 21 in the carnosine group compared to the control, final weight, growth and feed conversion were not influenced by the experimental diet.
    2 context sentences
    Summary · context
    To achieve this, a total of 1 080 1-day-old male Ross 308 chicks were distributed into two treatment groups in a randomized complete block design with 12 replicates per treatment.
    Summary · context
    The experimental groups included a basal diet and the same basal diet supplemented with 500 mg of carnosine/kg that were fed from d 1 to d 35.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In broiler chickens, feed conversion did not differ between carnosine and control diets.

    In plain wordsIn chickens, feed conversion did not differ between carnosine and basal diets.

    Peptide
    L-carnosine
    Outcome
    No significant changeFeed conversion
    Study

    chickenn = 1,080

    Male Ross 308 broiler chicks
    Comparator
    Basal diet
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    500 mg/kg diet · dietary · d 1 to d 35As given in this study (chicken).

    Source sentences

    Summary
    The data analysis revealed that apart from a slightly lower (P = 0.03) BW at d 21 in the carnosine group compared to the control, final weight, growth and feed conversion were not influenced by the experimental diet.
    2 context sentences
    Summary · context
    To achieve this, a total of 1 080 1-day-old male Ross 308 chicks were distributed into two treatment groups in a randomized complete block design with 12 replicates per treatment.
    Summary · context
    The experimental groups included a basal diet and the same basal diet supplemented with 500 mg of carnosine/kg that were fed from d 1 to d 35.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In broiler chickens, carcass weight did not differ between carnosine and control diets.

    In plain wordsIn chickens, carcass weight did not differ between carnosine and basal diets.

    Peptide
    L-carnosine
    Outcome
    No significant changeCarcass weight
    Study

    chickenn = 1,080

    Male Ross 308 broiler chicks
    Comparator
    Basal diet
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    500 mg/kg diet · dietary · d 1 to d 35As given in this study (chicken).

    Source sentences

    Summary
    Similarly, carcass weight, carcass yield, yield of carcass cuts and technological quality traits of breast meat did not differ between groups.
    2 context sentences
    Summary · context
    To achieve this, a total of 1 080 1-day-old male Ross 308 chicks were distributed into two treatment groups in a randomized complete block design with 12 replicates per treatment.
    Summary · context
    The experimental groups included a basal diet and the same basal diet supplemented with 500 mg of carnosine/kg that were fed from d 1 to d 35.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In broiler chickens, carcass yield did not differ between carnosine and control diets.

    In plain wordsIn chickens, carcass yield did not differ between carnosine and basal diets.

    Peptide
    L-carnosine
    Outcome
    No significant changeCarcass yield
    Study

    chickenn = 1,080

    Male Ross 308 broiler chicks
    Comparator
    Basal diet
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    500 mg/kg diet · dietary · d 1 to d 35As given in this study (chicken).

    Source sentences

    Summary
    Similarly, carcass weight, carcass yield, yield of carcass cuts and technological quality traits of breast meat did not differ between groups.
    2 context sentences
    Summary · context
    To achieve this, a total of 1 080 1-day-old male Ross 308 chicks were distributed into two treatment groups in a randomized complete block design with 12 replicates per treatment.
    Summary · context
    The experimental groups included a basal diet and the same basal diet supplemented with 500 mg of carnosine/kg that were fed from d 1 to d 35.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In broiler chickens, carcass cut yield did not differ between carnosine and control diets.

    In plain wordsIn chickens, carcass cut yield did not differ between carnosine and basal diets.

    Peptide
    L-carnosine
    Outcome
    No significant changeYield of carcass cuts
    Study

    chickenn = 1,080

    Male Ross 308 broiler chicks
    Comparator
    Basal diet
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    500 mg/kg diet · dietary · d 1 to d 35As given in this study (chicken).

    Source sentences

    Summary
    Similarly, carcass weight, carcass yield, yield of carcass cuts and technological quality traits of breast meat did not differ between groups.
    2 context sentences
    Summary · context
    To achieve this, a total of 1 080 1-day-old male Ross 308 chicks were distributed into two treatment groups in a randomized complete block design with 12 replicates per treatment.
    Summary · context
    The experimental groups included a basal diet and the same basal diet supplemented with 500 mg of carnosine/kg that were fed from d 1 to d 35.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In broiler chickens, breast meat technological quality traits did not differ between carnosine and control diets.

    In plain wordsIn chickens, breast meat quality traits did not differ between carnosine and basal diets.

    Peptide
    L-carnosine
    Outcome
    No significant changeBreast meat technological quality
    Study

    chickenn = 1,080

    Male Ross 308 broiler chicks
    Comparator
    Basal diet
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    500 mg/kg diet · dietary · d 1 to d 35As given in this study (chicken).

    Source sentences

    Summary
    Similarly, carcass weight, carcass yield, yield of carcass cuts and technological quality traits of breast meat did not differ between groups.
    2 context sentences
    Summary · context
    To achieve this, a total of 1 080 1-day-old male Ross 308 chicks were distributed into two treatment groups in a randomized complete block design with 12 replicates per treatment.
    Summary · context
    The experimental groups included a basal diet and the same basal diet supplemented with 500 mg of carnosine/kg that were fed from d 1 to d 35.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In broiler chickens, carnosine reduced White striping prevalence versus control.

    In plain wordsIn chickens, carnosine reduced White striping compared with the basal diet.

    Peptide
    L-carnosine
    Outcome
    DecreaseWhite striping prevalence
    Study

    chickenn = 1,080

    Male Ross 308 broiler chicks
    Comparator
    Basal diet
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    500 mg/kg diet · dietary · d 1 to d 35As given in this study (chicken).

    Source sentences

    Summary
    However, carnosine supplementation was associated with a reduction of the prevalence of White striping (P < 0.001), Wooden breast (P < 0.001) and the co-occurrence of these two myopathies (P < 0.001).
    2 context sentences
    Summary · context
    To achieve this, a total of 1 080 1-day-old male Ross 308 chicks were distributed into two treatment groups in a randomized complete block design with 12 replicates per treatment.
    Summary · context
    The experimental groups included a basal diet and the same basal diet supplemented with 500 mg of carnosine/kg that were fed from d 1 to d 35.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In broiler chickens, carnosine reduced Wooden breast prevalence versus control.

    In plain wordsIn chickens, carnosine reduced Wooden breast compared with the basal diet.

    Peptide
    L-carnosine
    Outcome
    DecreaseWooden breast prevalence
    Study

    chickenn = 1,080

    Male Ross 308 broiler chicks
    Comparator
    Basal diet
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    500 mg/kg diet · dietary · d 1 to d 35As given in this study (chicken).

    Source sentences

    Summary
    However, carnosine supplementation was associated with a reduction of the prevalence of White striping (P < 0.001), Wooden breast (P < 0.001) and the co-occurrence of these two myopathies (P < 0.001).
    2 context sentences
    Summary · context
    To achieve this, a total of 1 080 1-day-old male Ross 308 chicks were distributed into two treatment groups in a randomized complete block design with 12 replicates per treatment.
    Summary · context
    The experimental groups included a basal diet and the same basal diet supplemented with 500 mg of carnosine/kg that were fed from d 1 to d 35.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In broiler chickens, carnosine reduced co-occurrence of White striping and Wooden breast versus control.

    In plain wordsIn chickens, carnosine reduced simultaneous White striping and Wooden breast compared with the basal diet.

    Peptide
    L-carnosine
    Outcome
    DecreaseCo-occurring breast myopathies
    Study

    chickenn = 1,080

    Male Ross 308 broiler chicks
    Comparator
    Basal diet
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    500 mg/kg diet · dietary · d 1 to d 35As given in this study (chicken).

    Source sentences

    Summary
    However, carnosine supplementation was associated with a reduction of the prevalence of White striping (P < 0.001), Wooden breast (P < 0.001) and the co-occurrence of these two myopathies (P < 0.001).
    2 context sentences
    Summary · context
    To achieve this, a total of 1 080 1-day-old male Ross 308 chicks were distributed into two treatment groups in a randomized complete block design with 12 replicates per treatment.
    Summary · context
    The experimental groups included a basal diet and the same basal diet supplemented with 500 mg of carnosine/kg that were fed from d 1 to d 35.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In broiler chickens, carnosine increased breast muscle antioxidant potential versus control.

    In plain wordsIn chickens, carnosine increased breast muscle antioxidant potential compared with the basal diet.

    Peptide
    L-carnosine
    Outcome
    IncreaseBreast muscle antioxidant potential
    Study

    chickenn = 1,080

    Male Ross 308 broiler chicks
    Comparator
    Basal diet
    Outcome group
    Oxidative stress · Musculoskeletal
    Studied dose
    500 mg/kg diet · dietary · d 1 to d 35As given in this study (chicken).

    Source sentences

    Summary
    Moreover, carnosine supplementation increased (P < 0.001) the antioxidant potential of breast muscles while malonaldehyde and carbonyl concentrations remained similar in the experimental group relative to the control group.
    2 context sentences
    Summary · context
    To achieve this, a total of 1 080 1-day-old male Ross 308 chicks were distributed into two treatment groups in a randomized complete block design with 12 replicates per treatment.
    Summary · context
    The experimental groups included a basal diet and the same basal diet supplemented with 500 mg of carnosine/kg that were fed from d 1 to d 35.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In broiler chickens, malonaldehyde concentrations were similar with carnosine and control diets.

    In plain wordsIn chickens, malonaldehyde concentrations were similar with carnosine and basal diets.

    Peptide
    L-carnosine
    Outcome
    No significant changeMalonaldehyde concentration
    Study

    chickenn = 1,080

    Male Ross 308 broiler chicks
    Comparator
    Basal diet
    Outcome group
    Oxidative stress · Musculoskeletal
    Studied dose
    500 mg/kg diet · dietary · d 1 to d 35As given in this study (chicken).

    Source sentences

    Summary
    Moreover, carnosine supplementation increased (P < 0.001) the antioxidant potential of breast muscles while malonaldehyde and carbonyl concentrations remained similar in the experimental group relative to the control group.
    2 context sentences
    Summary · context
    To achieve this, a total of 1 080 1-day-old male Ross 308 chicks were distributed into two treatment groups in a randomized complete block design with 12 replicates per treatment.
    Summary · context
    The experimental groups included a basal diet and the same basal diet supplemented with 500 mg of carnosine/kg that were fed from d 1 to d 35.
  14. 14AnimalAnimal study (in vivo)Mechanism

    In broiler chickens, carbonyl concentrations were similar with carnosine and control diets.

    In plain wordsIn chickens, carbonyl concentrations were similar with carnosine and basal diets.

    Peptide
    L-carnosine
    Outcome
    No significant changeCarbonyl concentration
    Study

    chickenn = 1,080

    Male Ross 308 broiler chicks
    Comparator
    Basal diet
    Outcome group
    Oxidative stress · Musculoskeletal
    Studied dose
    500 mg/kg diet · dietary · d 1 to d 35As given in this study (chicken).

    Source sentences

    Summary
    Moreover, carnosine supplementation increased (P < 0.001) the antioxidant potential of breast muscles while malonaldehyde and carbonyl concentrations remained similar in the experimental group relative to the control group.
    2 context sentences
    Summary · context
    To achieve this, a total of 1 080 1-day-old male Ross 308 chicks were distributed into two treatment groups in a randomized complete block design with 12 replicates per treatment.
    Summary · context
    The experimental groups included a basal diet and the same basal diet supplemented with 500 mg of carnosine/kg that were fed from d 1 to d 35.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

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