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Study · Animal study (in vivo) · mouse · 2015

6 results

Carnosine decreases IGFBP1 production in db/db mice through suppression of HIF-1.

Forsberg EA, Botusan IR, Wang J, Peters V, Ansurudeen I, Brismar K, Catrina SB

The Journal of endocrinology13 Apr 2015Cited by 30 (Europe PMC)

PMID25869614 (opens in a new tab)DOI10.1530/joe-14-0571 (opens in a new tab)PepBankPUB-25869614
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In db/db mice, carnosine decreased circulating IGFBP1 levels.

    In plain wordsIn diabetic mice, carnosine decreased circulating IGFBP1 levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseCirculating IGFBP1
    Study

    mousen: not reported in source

    db/db mice
    Outcome group
    Growth hormone and IGF-1 · Metabolic and weight
    Studied dose
    Dose not stated · oral in water · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Carnosine decreased the circulating IGFBP1 levels and the liver expression Igfbp1, through a complex mechanism acting both directly by suppressing the HIF-1α-mediated IGFBP1 induction and indirectly through increasing circulating insulin level followed by a decrease in the blood glucose levels and i…
    1 context sentence
    Summary · context
    Db/db mice and heterozygous non-diabetic mice received for 4 weeks regular water or water supplemented with carnosine.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In db/db mice, carnosine decreased liver Igfbp1 expression.

    In plain wordsIn diabetic mice, carnosine decreased liver Igfbp1 expression.

    Peptide
    L-carnosine
    Outcome
    DecreaseLiver Igfbp1 expression
    Study

    mousen: not reported in source

    db/db mice
    Outcome group
    Growth hormone and IGF-1 · Metabolic and weight
    Studied dose
    Dose not stated · oral in water · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Carnosine decreased the circulating IGFBP1 levels and the liver expression Igfbp1, through a complex mechanism acting both directly by suppressing the HIF-1α-mediated IGFBP1 induction and indirectly through increasing circulating insulin level followed by a decrease in the blood glucose levels and i…
    1 context sentence
    Summary · context
    Db/db mice and heterozygous non-diabetic mice received for 4 weeks regular water or water supplemented with carnosine.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In db/db mice, carnosine increased circulating insulin levels.

    In plain wordsIn diabetic mice, carnosine increased circulating insulin levels.

    Peptide
    L-carnosine
    Outcome
    IncreaseCirculating insulin
    Study

    mousen: not reported in source

    db/db mice
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · oral in water · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Carnosine decreased the circulating IGFBP1 levels and the liver expression Igfbp1, through a complex mechanism acting both directly by suppressing the HIF-1α-mediated IGFBP1 induction and indirectly through increasing circulating insulin level followed by a decrease in the blood glucose levels and i…
    1 context sentence
    Summary · context
    Db/db mice and heterozygous non-diabetic mice received for 4 weeks regular water or water supplemented with carnosine.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In db/db mice, carnosine decreased blood glucose levels.

    In plain wordsIn diabetic mice, carnosine decreased blood glucose levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseBlood glucose
    Study

    mousen: not reported in source

    db/db mice
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · oral in water · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Carnosine decreased the circulating IGFBP1 levels and the liver expression Igfbp1, through a complex mechanism acting both directly by suppressing the HIF-1α-mediated IGFBP1 induction and indirectly through increasing circulating insulin level followed by a decrease in the blood glucose levels and i…
    1 context sentence
    Summary · context
    Db/db mice and heterozygous non-diabetic mice received for 4 weeks regular water or water supplemented with carnosine.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In db/db mice, carnosine increased plasma IGF1 levels.

    In plain wordsIn diabetic mice, carnosine increased plasma IGF1 levels.

    Peptide
    L-carnosine
    Outcome
    IncreasePlasma IGF1
    Study

    mousen: not reported in source

    db/db mice
    Outcome group
    Growth hormone and IGF-1 · Metabolic and weight
    Studied dose
    Dose not stated · oral in water · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Carnosine decreased the circulating IGFBP1 levels and the liver expression Igfbp1, through a complex mechanism acting both directly by suppressing the HIF-1α-mediated IGFBP1 induction and indirectly through increasing circulating insulin level followed by a decrease in the blood glucose levels and i…
    1 context sentence
    Summary · context
    Db/db mice and heterozygous non-diabetic mice received for 4 weeks regular water or water supplemented with carnosine.
  6. 06LabOther designMechanism

    In experiments with carnosine, HIF-1α-mediated IGFBP1 induction was suppressed, but the abstract does not assign the model explicitly.

    In plain wordsIn lab tests, carnosine suppressed HIF-1α-mediated IGFBP1 induction. The abstract does not specify the model for this result.

    Peptide
    L-carnosine
    Outcome
    DecreaseHIF-1α-mediated IGFBP1 induction
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Carnosine decreased the circulating IGFBP1 levels and the liver expression Igfbp1, through a complex mechanism acting both directly by suppressing the HIF-1α-mediated IGFBP1 induction and indirectly through increasing circulating insulin level followed by a decrease in the blood glucose levels and i…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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