Supplementation-induced change in muscle carnosine is paralleled by changes in muscle metabolism, protein glycation and reactive carbonyl species sequestering.

Schön M, Just I, Krumpolec P, Blažíček P, Valkovič L, Aldini G, Tsai CL, De Courten B, Krššák M, Ukropcová B, Ukropec J

Physiological research22 Dec 2022Cited by 5 (Europe PMC)

PMID36545878PMCIDPMC10069809DOI10.33549/physiolres.934911PepBankPUB-36545878

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

4 results from studies that gave the peptide. 4 results from people.

01HumanNon-randomized trialPharmacokinetics
In overweight-to-obese adults, supplementation increased muscle carnosine.
In plain wordsIn overweight-to-obese adults, supplementation increased muscle carnosine.
Peptide
L-carnosine
Outcome
IncreaseMuscle carnosine
Study
n = 12
Outcome group
Pharmacokinetics · Musculoskeletal
Studied dose
2 g/day · 12 weeksAs given in this study (human).
Source sentences
Summary
Supplementation-induced increase in muscle carnosine was paralleled by improved dynamics of muscle post-exercise phosphocreatine recovery, decreased serum albumin glycation and enhanced urinary carnosine-propanal excretion (all p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we explored interrelations between carnosine supplementation (2 g/day, 12 weeks) induced effects on carnosine muscle loading and parallel changes in (i) muscle energy metabolism, (ii) serum albumin glycation and (iii) reactive carbonyl species sequestering in twelve (M/F=10/2) sedentar…
Report a problemFND-3654587801
02HumanNon-randomized trialEfficacy outcome
In overweight-to-obese adults, increased muscle carnosine accompanied improved post-exercise phosphocreatine recovery.
In plain wordsIn overweight-to-obese adults, increased muscle carnosine accompanied improved muscle energy recovery after exercise.
Peptide
L-carnosine
Outcome
IncreasePost-exercise phosphocreatine recovery
Study
n = 12
Outcome group
Exercise and physical function · Musculoskeletal
Studied dose
2 g/day · 12 weeksAs given in this study (human).
Source sentences
Summary
Supplementation-induced increase in muscle carnosine was paralleled by improved dynamics of muscle post-exercise phosphocreatine recovery, decreased serum albumin glycation and enhanced urinary carnosine-propanal excretion (all p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we explored interrelations between carnosine supplementation (2 g/day, 12 weeks) induced effects on carnosine muscle loading and parallel changes in (i) muscle energy metabolism, (ii) serum albumin glycation and (iii) reactive carbonyl species sequestering in twelve (M/F=10/2) sedentar…
Report a problemFND-3654587802
03HumanNon-randomized trialEfficacy outcome
In overweight-to-obese adults, increased muscle carnosine accompanied decreased serum albumin glycation.
In plain wordsIn overweight-to-obese adults, increased muscle carnosine accompanied less sugar attachment to serum albumin.
Peptide
L-carnosine
Outcome
DecreaseSerum albumin glycation
Study
n = 12
Outcome group
Glycemic control · Metabolic and weight
Studied dose
2 g/day · 12 weeksAs given in this study (human).
Source sentences
Summary
Supplementation-induced increase in muscle carnosine was paralleled by improved dynamics of muscle post-exercise phosphocreatine recovery, decreased serum albumin glycation and enhanced urinary carnosine-propanal excretion (all p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we explored interrelations between carnosine supplementation (2 g/day, 12 weeks) induced effects on carnosine muscle loading and parallel changes in (i) muscle energy metabolism, (ii) serum albumin glycation and (iii) reactive carbonyl species sequestering in twelve (M/F=10/2) sedentar…
Report a problemFND-3654587803
04HumanNon-randomized trialPharmacokinetics
In overweight-to-obese adults, increased muscle carnosine accompanied enhanced urinary carnosine-propanal excretion.
In plain wordsIn overweight-to-obese adults, increased muscle carnosine accompanied greater carnosine-propanal excretion in urine.
Peptide
L-carnosine
Outcome
IncreaseUrinary carnosine-propanal excretion
Study
n = 12
Outcome group
Pharmacokinetics · Kidney and urinary
Studied dose
2 g/day · 12 weeksAs given in this study (human).
Source sentences
Summary
Supplementation-induced increase in muscle carnosine was paralleled by improved dynamics of muscle post-exercise phosphocreatine recovery, decreased serum albumin glycation and enhanced urinary carnosine-propanal excretion (all p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we explored interrelations between carnosine supplementation (2 g/day, 12 weeks) induced effects on carnosine muscle loading and parallel changes in (i) muscle energy metabolism, (ii) serum albumin glycation and (iii) reactive carbonyl species sequestering in twelve (M/F=10/2) sedentar…
Report a problemFND-3654587804

Studies that did not test the peptide alone4

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

05HumanNot a test of L-carnosine aloneObservational studyOther
In twelve adults given carnosine, greater muscle carnosine accumulation occurred in those with lower baseline muscle carnosine, lower BMI, higher physical activity and lower resting intramuscular pH, with similar muscle mass and dietary protein preference.
In plain wordsIn twelve adults, greater muscle carnosine gains occurred with lower starting carnosine, BMI and muscle pH, and higher physical activity.
Peptide
L-carnosine
Outcome
MixedBaseline predictors of muscle carnosine accumulation
Study
n = 12
Outcome group
Pharmacokinetics · Musculoskeletal
Source sentences
Summary
Magnitude of supplementation-induced muscle carnosine accumulation was higher in individuals with lower baseline muscle carnosine, who had lower BMI, higher physical activity level, lower resting intramuscular pH, but similar muscle mass and dietary protein preference.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we explored interrelations between carnosine supplementation (2 g/day, 12 weeks) induced effects on carnosine muscle loading and parallel changes in (i) muscle energy metabolism, (ii) serum albumin glycation and (iii) reactive carbonyl species sequestering in twelve (M/F=10/2) sedentar…
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3654587805
06HumanNot a test of L-carnosine aloneObservational studyMechanism
In supplemented adults, increased muscle carnosine correlated with reduced protein glycation.
In plain wordsIn supplemented adults, increased muscle carnosine was linked to less protein glycation.
Peptide
L-carnosine
Outcome
DecreaseProtein glycation association
Study
n = 12
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
Level of supplementation-induced increase in muscle carnosine correlated with reduction of protein glycation, increase in reactive carbonyl species sequestering, and acceleration of muscle post-exercise phosphocreatine recovery.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we explored interrelations between carnosine supplementation (2 g/day, 12 weeks) induced effects on carnosine muscle loading and parallel changes in (i) muscle energy metabolism, (ii) serum albumin glycation and (iii) reactive carbonyl species sequestering in twelve (M/F=10/2) sedentar…
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3654587807
07HumanNot a test of L-carnosine aloneObservational studyMechanism
In supplemented adults, increased muscle carnosine correlated with increased reactive carbonyl species sequestration.
In plain wordsIn supplemented adults, increased muscle carnosine was linked to greater capture of reactive carbonyl compounds.
Peptide
L-carnosine
Outcome
IncreaseReactive carbonyl sequestration association
Study
n = 12
Outcome group
Receptor activity and mechanism · Whole body
Source sentences
Summary
Level of supplementation-induced increase in muscle carnosine correlated with reduction of protein glycation, increase in reactive carbonyl species sequestering, and acceleration of muscle post-exercise phosphocreatine recovery.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we explored interrelations between carnosine supplementation (2 g/day, 12 weeks) induced effects on carnosine muscle loading and parallel changes in (i) muscle energy metabolism, (ii) serum albumin glycation and (iii) reactive carbonyl species sequestering in twelve (M/F=10/2) sedentar…
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3654587808
08HumanNot a test of L-carnosine aloneObservational studyMechanism
In supplemented adults, increased muscle carnosine correlated with faster post-exercise phosphocreatine recovery.
In plain wordsIn supplemented adults, increased muscle carnosine was linked to faster muscle energy recovery after exercise.
Peptide
L-carnosine
Outcome
IncreasePhosphocreatine recovery association
Study
n = 12
Outcome group
Exercise and physical function · Musculoskeletal
Source sentences
Summary
Level of supplementation-induced increase in muscle carnosine correlated with reduction of protein glycation, increase in reactive carbonyl species sequestering, and acceleration of muscle post-exercise phosphocreatine recovery.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we explored interrelations between carnosine supplementation (2 g/day, 12 weeks) induced effects on carnosine muscle loading and parallel changes in (i) muscle energy metabolism, (ii) serum albumin glycation and (iii) reactive carbonyl species sequestering in twelve (M/F=10/2) sedentar…
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3654587809

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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