The effect of carnosine treatment on prooxidant-antioxidant balance in liver, heart and brain tissues of male aged rats.

Aydin AF, Küçükgergin C, Ozdemirler-Erata G, Koçak-Toker N, Uysal M

Biogerontology10 May 2009Cited by 64 (Europe PMC)

PMID19430956DOI10.1007/s10522-009-9232-4PepBankPUB-19430956

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, carnosine decreased elevated liver MDA levels.
In plain wordsIn aged rats, carnosine decreased elevated liver MDA levels.
Peptide
L-carnosine
Outcome
DecreaseLiver MDA
Study
ratn: not reported in source
Male aged rats
Outcome group
Inflammation markers · Liver
Studied dose
250 mg/kg daily · intraperitoneal · 1 monthAs given in this study (rat).
Source sentences
Summary
Carnosine treatment decreased high MDA, DC and PC levels and caused significant increases in vitamin E level and SOD activity in the liver of aged rats.
3 context sentences(design, population, supporting numbers)
Summary · context
This study was done to investigate the effects of carnosine treatment on lipid peroxidation and antioxidant status of liver, heart, brain in male young and aged rats.
Summary · context
At the initiation of study, young and aged rats were 5 and 22 months old, respectively.
Summary · context
Carnosine (250 mg/kg, daily, i.p.) was administered for 1 month to rats.
Report a problemFND-1943095601
02AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, carnosine decreased elevated liver diene conjugate levels.
In plain wordsIn aged rats, carnosine decreased elevated liver diene conjugate levels.
Peptide
L-carnosine
Outcome
DecreaseLiver diene conjugates
Study
ratn: not reported in source
Male aged rats
Outcome group
Inflammation markers · Liver
Studied dose
250 mg/kg daily · intraperitoneal · 1 monthAs given in this study (rat).
Source sentences
Summary
Carnosine treatment decreased high MDA, DC and PC levels and caused significant increases in vitamin E level and SOD activity in the liver of aged rats.
3 context sentences(design, population, supporting numbers)
Summary · context
This study was done to investigate the effects of carnosine treatment on lipid peroxidation and antioxidant status of liver, heart, brain in male young and aged rats.
Summary · context
At the initiation of study, young and aged rats were 5 and 22 months old, respectively.
Summary · context
Carnosine (250 mg/kg, daily, i.p.) was administered for 1 month to rats.
Report a problemFND-1943095602
03AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, carnosine decreased elevated liver protein carbonyl levels.
In plain wordsIn aged rats, carnosine decreased elevated liver protein carbonyl levels.
Peptide
L-carnosine
Outcome
DecreaseLiver protein carbonyl
Study
ratn: not reported in source
Male aged rats
Outcome group
Inflammation markers · Liver
Studied dose
250 mg/kg daily · intraperitoneal · 1 monthAs given in this study (rat).
Source sentences
Summary
Carnosine treatment decreased high MDA, DC and PC levels and caused significant increases in vitamin E level and SOD activity in the liver of aged rats.
3 context sentences(design, population, supporting numbers)
Summary · context
This study was done to investigate the effects of carnosine treatment on lipid peroxidation and antioxidant status of liver, heart, brain in male young and aged rats.
Summary · context
At the initiation of study, young and aged rats were 5 and 22 months old, respectively.
Summary · context
Carnosine (250 mg/kg, daily, i.p.) was administered for 1 month to rats.
Report a problemFND-1943095603
04AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, carnosine significantly increased liver vitamin E levels.
In plain wordsIn aged rats, carnosine increased liver vitamin E levels.
Peptide
L-carnosine
Outcome
IncreaseLiver vitamin E
Study
ratn: not reported in source
Male aged rats
Outcome group
Inflammation markers · Liver
Studied dose
250 mg/kg daily · intraperitoneal · 1 monthAs given in this study (rat).
Source sentences
Summary
Carnosine treatment decreased high MDA, DC and PC levels and caused significant increases in vitamin E level and SOD activity in the liver of aged rats.
3 context sentences(design, population, supporting numbers)
Summary · context
This study was done to investigate the effects of carnosine treatment on lipid peroxidation and antioxidant status of liver, heart, brain in male young and aged rats.
Summary · context
At the initiation of study, young and aged rats were 5 and 22 months old, respectively.
Summary · context
Carnosine (250 mg/kg, daily, i.p.) was administered for 1 month to rats.
Report a problemFND-1943095604
05AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, carnosine significantly increased liver SOD activity.
In plain wordsIn aged rats, carnosine increased liver SOD activity.
Peptide
L-carnosine
Outcome
IncreaseLiver SOD activity
Study
ratn: not reported in source
Male aged rats
Outcome group
Inflammation markers · Liver
Studied dose
250 mg/kg daily · intraperitoneal · 1 monthAs given in this study (rat).
Source sentences
Summary
Carnosine treatment decreased high MDA, DC and PC levels and caused significant increases in vitamin E level and SOD activity in the liver of aged rats.
3 context sentences(design, population, supporting numbers)
Summary · context
This study was done to investigate the effects of carnosine treatment on lipid peroxidation and antioxidant status of liver, heart, brain in male young and aged rats.
Summary · context
At the initiation of study, young and aged rats were 5 and 22 months old, respectively.
Summary · context
Carnosine (250 mg/kg, daily, i.p.) was administered for 1 month to rats.
Report a problemFND-1943095605
06AnimalAnimal study (in vivo)Efficacy outcome
In aged rats receiving carnosine, heart non-enzymatic antioxidants did not change.
In plain wordsIn aged rats receiving carnosine, heart non-enzymatic antioxidants did not change.
Peptide
L-carnosine
Outcome
No significant changeHeart non-enzymatic antioxidants
Study
ratn: not reported in source
Male aged rats
Outcome group
Inflammation markers · Cardiovascular
Studied dose
250 mg/kg daily · intraperitoneal · 1 monthAs given in this study (rat).
Source sentences
Summary
There were no changes in non-enzymatic and enzymatic antioxidants in the heart and brain of carnosine-treated aged rats.
3 context sentences(design, population, supporting numbers)
Summary · context
This study was done to investigate the effects of carnosine treatment on lipid peroxidation and antioxidant status of liver, heart, brain in male young and aged rats.
Summary · context
At the initiation of study, young and aged rats were 5 and 22 months old, respectively.
Summary · context
Carnosine (250 mg/kg, daily, i.p.) was administered for 1 month to rats.
Report a problemFND-1943095606
07AnimalAnimal study (in vivo)Efficacy outcome
In aged rats receiving carnosine, heart enzymatic antioxidants did not change.
In plain wordsIn aged rats receiving carnosine, heart enzymatic antioxidants did not change.
Peptide
L-carnosine
Outcome
No significant changeHeart enzymatic antioxidants
Study
ratn: not reported in source
Male aged rats
Outcome group
Inflammation markers · Cardiovascular
Studied dose
250 mg/kg daily · intraperitoneal · 1 monthAs given in this study (rat).
Source sentences
Summary
There were no changes in non-enzymatic and enzymatic antioxidants in the heart and brain of carnosine-treated aged rats.
3 context sentences(design, population, supporting numbers)
Summary · context
This study was done to investigate the effects of carnosine treatment on lipid peroxidation and antioxidant status of liver, heart, brain in male young and aged rats.
Summary · context
At the initiation of study, young and aged rats were 5 and 22 months old, respectively.
Summary · context
Carnosine (250 mg/kg, daily, i.p.) was administered for 1 month to rats.
Report a problemFND-1943095607
08AnimalAnimal study (in vivo)Efficacy outcome
In aged rats receiving carnosine, brain non-enzymatic antioxidants did not change.
In plain wordsIn aged rats receiving carnosine, brain non-enzymatic antioxidants did not change.
Peptide
L-carnosine
Outcome
No significant changeBrain non-enzymatic antioxidants
Study
ratn: not reported in source
Male aged rats
Outcome group
Inflammation markers · Nervous system and cognition
Studied dose
250 mg/kg daily · intraperitoneal · 1 monthAs given in this study (rat).
Source sentences
Summary
There were no changes in non-enzymatic and enzymatic antioxidants in the heart and brain of carnosine-treated aged rats.
3 context sentences(design, population, supporting numbers)
Summary · context
This study was done to investigate the effects of carnosine treatment on lipid peroxidation and antioxidant status of liver, heart, brain in male young and aged rats.
Summary · context
At the initiation of study, young and aged rats were 5 and 22 months old, respectively.
Summary · context
Carnosine (250 mg/kg, daily, i.p.) was administered for 1 month to rats.
Report a problemFND-1943095608
09AnimalAnimal study (in vivo)Efficacy outcome
In aged rats receiving carnosine, brain enzymatic antioxidants did not change.
In plain wordsIn aged rats receiving carnosine, brain enzymatic antioxidants did not change.
Peptide
L-carnosine
Outcome
No significant changeBrain enzymatic antioxidants
Study
ratn: not reported in source
Male aged rats
Outcome group
Inflammation markers · Nervous system and cognition
Studied dose
250 mg/kg daily · intraperitoneal · 1 monthAs given in this study (rat).
Source sentences
Summary
There were no changes in non-enzymatic and enzymatic antioxidants in the heart and brain of carnosine-treated aged rats.
3 context sentences(design, population, supporting numbers)
Summary · context
This study was done to investigate the effects of carnosine treatment on lipid peroxidation and antioxidant status of liver, heart, brain in male young and aged rats.
Summary · context
At the initiation of study, young and aged rats were 5 and 22 months old, respectively.
Summary · context
Carnosine (250 mg/kg, daily, i.p.) was administered for 1 month to rats.
Report a problemFND-1943095609

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

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