Effects of Carnosine (Beta-Alanyl-L-Histidine) in an Experimental Rat Model of Acute Kidney Injury Due to Septic Shock.

Sahin S, Burukoglu Donmez D

Medical science monitor : international medical journal of experimental and clinical research15 Jan 2018Cited by 13 (Europe PMC)

PMID29334583PMCIDPMC5778771DOI10.12659/msm.905181PepBankPUB-29334583

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In septic shock rats, carnosine significantly improved kidney function compared with septic shock without carnosine.
In plain wordsIn rats with septic shock, carnosine improved kidney function compared with no carnosine.
Peptide
L-carnosine
Outcome
Direction not reportedKidney function
Study
ratn: not reported in source
Sprague-Dawley rats with cecal ligation and puncture septic shock
Comparator
septic shock without carnosine
Outcome group
Kidney function · Kidney and urinary
Studied dose
250 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
RESULTS Statistically significant improvements were observed in kidney function, tissue and serum malondialdehyde levels, routine blood values, biochemical indices, and in histopathological findings in rats in Group 3 who were treated with carnosine, compared with Group 2 exposed to septic shock wit…
3 context sentences(design, population, supporting numbers)
Summary · context
Kidney function and the histological findings of AKI were investigated in an experimental rat model with sepsis induced by cecal ligation and puncture (CLP) and compared with and without treatment with carnosine (beta-alanyl-L-histidine).
Summary · context
Rats in Group 3 received an intraperitoneal (IP) injection of 250 mg/kg carnosine, 60 min following CLP.
Summary · context
Twenty-four hours following CLP, rats were sacrificed, and blood and renal tissue samples were collected.
Report a problemFND-2933458301
02AnimalAnimal study (in vivo)Efficacy outcome
In septic shock rats, carnosine significantly improved tissue malondialdehyde levels compared with septic shock without carnosine.
In plain wordsIn rats with septic shock, carnosine improved tissue malondialdehyde levels compared with no carnosine.
Peptide
L-carnosine
Outcome
Direction not reportedTissue malondialdehyde
Study
ratn: not reported in source
Sprague-Dawley rats with cecal ligation and puncture septic shock
Comparator
septic shock without carnosine
Outcome group
Aging markers · Kidney and urinary
Studied dose
250 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
RESULTS Statistically significant improvements were observed in kidney function, tissue and serum malondialdehyde levels, routine blood values, biochemical indices, and in histopathological findings in rats in Group 3 who were treated with carnosine, compared with Group 2 exposed to septic shock wit…
3 context sentences(design, population, supporting numbers)
Summary · context
Kidney function and the histological findings of AKI were investigated in an experimental rat model with sepsis induced by cecal ligation and puncture (CLP) and compared with and without treatment with carnosine (beta-alanyl-L-histidine).
Summary · context
Rats in Group 3 received an intraperitoneal (IP) injection of 250 mg/kg carnosine, 60 min following CLP.
Summary · context
Twenty-four hours following CLP, rats were sacrificed, and blood and renal tissue samples were collected.
Report a problemFND-2933458302
03AnimalAnimal study (in vivo)Efficacy outcome
In septic shock rats, carnosine significantly improved serum malondialdehyde levels compared with septic shock without carnosine.
In plain wordsIn rats with septic shock, carnosine improved serum malondialdehyde levels compared with no carnosine.
Peptide
L-carnosine
Outcome
Direction not reportedSerum malondialdehyde
Study
ratn: not reported in source
Sprague-Dawley rats with cecal ligation and puncture septic shock
Comparator
septic shock without carnosine
Outcome group
Aging markers · Kidney and urinary
Studied dose
250 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
RESULTS Statistically significant improvements were observed in kidney function, tissue and serum malondialdehyde levels, routine blood values, biochemical indices, and in histopathological findings in rats in Group 3 who were treated with carnosine, compared with Group 2 exposed to septic shock wit…
3 context sentences(design, population, supporting numbers)
Summary · context
Kidney function and the histological findings of AKI were investigated in an experimental rat model with sepsis induced by cecal ligation and puncture (CLP) and compared with and without treatment with carnosine (beta-alanyl-L-histidine).
Summary · context
Rats in Group 3 received an intraperitoneal (IP) injection of 250 mg/kg carnosine, 60 min following CLP.
Summary · context
Twenty-four hours following CLP, rats were sacrificed, and blood and renal tissue samples were collected.
Report a problemFND-2933458303
04AnimalAnimal study (in vivo)Efficacy outcome
In septic shock rats, carnosine significantly improved routine blood values compared with septic shock without carnosine.
In plain wordsIn rats with septic shock, carnosine improved routine blood values compared with no carnosine.
Peptide
L-carnosine
Outcome
Direction not reportedRoutine blood values
Study
ratn: not reported in source
Sprague-Dawley rats with cecal ligation and puncture septic shock
Comparator
septic shock without carnosine
Outcome group
Blood biochemical markers · Kidney and urinary
Studied dose
250 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
RESULTS Statistically significant improvements were observed in kidney function, tissue and serum malondialdehyde levels, routine blood values, biochemical indices, and in histopathological findings in rats in Group 3 who were treated with carnosine, compared with Group 2 exposed to septic shock wit…
3 context sentences(design, population, supporting numbers)
Summary · context
Kidney function and the histological findings of AKI were investigated in an experimental rat model with sepsis induced by cecal ligation and puncture (CLP) and compared with and without treatment with carnosine (beta-alanyl-L-histidine).
Summary · context
Rats in Group 3 received an intraperitoneal (IP) injection of 250 mg/kg carnosine, 60 min following CLP.
Summary · context
Twenty-four hours following CLP, rats were sacrificed, and blood and renal tissue samples were collected.
Report a problemFND-2933458304
05AnimalAnimal study (in vivo)Efficacy outcome
In septic shock rats, carnosine significantly improved biochemical indices compared with septic shock without carnosine.
In plain wordsIn rats with septic shock, carnosine improved biochemical indices compared with no carnosine.
Peptide
L-carnosine
Outcome
Direction not reportedBiochemical indices
Study
ratn: not reported in source
Sprague-Dawley rats with cecal ligation and puncture septic shock
Comparator
septic shock without carnosine
Outcome group
Blood biochemical markers · Kidney and urinary
Studied dose
250 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
RESULTS Statistically significant improvements were observed in kidney function, tissue and serum malondialdehyde levels, routine blood values, biochemical indices, and in histopathological findings in rats in Group 3 who were treated with carnosine, compared with Group 2 exposed to septic shock wit…
3 context sentences(design, population, supporting numbers)
Summary · context
Kidney function and the histological findings of AKI were investigated in an experimental rat model with sepsis induced by cecal ligation and puncture (CLP) and compared with and without treatment with carnosine (beta-alanyl-L-histidine).
Summary · context
Rats in Group 3 received an intraperitoneal (IP) injection of 250 mg/kg carnosine, 60 min following CLP.
Summary · context
Twenty-four hours following CLP, rats were sacrificed, and blood and renal tissue samples were collected.
Report a problemFND-2933458305
06AnimalAnimal study (in vivo)Efficacy outcome
In septic shock rats, carnosine significantly improved histopathological findings compared with septic shock without carnosine.
In plain wordsIn rats with septic shock, carnosine improved kidney tissue findings compared with no carnosine.
Peptide
L-carnosine
Outcome
Direction not reportedRenal histopathology
Study
ratn: not reported in source
Sprague-Dawley rats with cecal ligation and puncture septic shock
Comparator
septic shock without carnosine
Outcome group
Kidney function · Kidney and urinary
Studied dose
250 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
RESULTS Statistically significant improvements were observed in kidney function, tissue and serum malondialdehyde levels, routine blood values, biochemical indices, and in histopathological findings in rats in Group 3 who were treated with carnosine, compared with Group 2 exposed to septic shock wit…
3 context sentences(design, population, supporting numbers)
Summary · context
Kidney function and the histological findings of AKI were investigated in an experimental rat model with sepsis induced by cecal ligation and puncture (CLP) and compared with and without treatment with carnosine (beta-alanyl-L-histidine).
Summary · context
Rats in Group 3 received an intraperitoneal (IP) injection of 250 mg/kg carnosine, 60 min following CLP.
Summary · context
Twenty-four hours following CLP, rats were sacrificed, and blood and renal tissue samples were collected.
Report a problemFND-2933458306

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Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

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