Effects of carnosine supplementation on markers for the pathophysiological development of metabolic dysfunction-associated steatotic liver disease in a diet-induced model.

Grandini NA, Costa MR, Gregolin CS, Siqueira JS, Vieira TA, Togneri Ferron AJ, Francisqueti-Ferron FV, Romualdo GR, Lúcia Dos Anjos Ferreira A, Aldini G, Corrêa CR, Moreto F

Molecular and cellular endocrinology24 Dec 2023Cited by 6 (Europe PMC)

PMID38147954DOI10.1016/j.mce.2023.112138PepBankPUB-38147954

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with MASLD, carnosine reduced plasma triglycerides compared with untreated MASLD rats.
In plain wordsIn rats with MASLD, carnosine reduced blood triglycerides compared with untreated MASLD rats.
Peptide
L-carnosine
Outcome
DecreasePlasma triglycerides
Study
ratn = 12
Diet-induced MASLD in male Wistar rats
Comparator
Untreated MASLD group
Outcome group
Lipids · Metabolic and weight
Studied dose
250 mg/kg · intraperitoneal · 4 weeksAs given in this study (rat).
Source sentences
Summary
CAR attenuated plasma and hepatic triglyceride and cholesterol levels, hepatic steatosis, CD68⁺ macrophages, and hepatic oxidative markers, in addition to increasing HDL cholesterol levels and PPAR-α, compared to the untreated MASLD group.
2 context sentences(design, population, supporting numbers)
Summary · context
This work aimed to evaluate the effects of CAR on diet-induced MASLD in rats.
Summary · context
After, the animals were redistributed to begin the treatment with CAR (4 weeks): Co (n = 6), Co + CAR (n = 6), MASLD (n = 6), and MASLD + CAR (n = 6), administered intraperitoneally (250 mg/kg).
Report a problemFND-3814795401
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with MASLD, carnosine reduced hepatic triglycerides compared with untreated MASLD rats.
In plain wordsIn rats with MASLD, carnosine reduced liver triglycerides compared with untreated MASLD rats.
Peptide
L-carnosine
Outcome
DecreaseHepatic triglycerides
Study
ratn = 12
Diet-induced MASLD in male Wistar rats
Comparator
Untreated MASLD group
Outcome group
Liver fat and liver function · Liver
Studied dose
250 mg/kg · intraperitoneal · 4 weeksAs given in this study (rat).
Source sentences
Summary
CAR attenuated plasma and hepatic triglyceride and cholesterol levels, hepatic steatosis, CD68⁺ macrophages, and hepatic oxidative markers, in addition to increasing HDL cholesterol levels and PPAR-α, compared to the untreated MASLD group.
2 context sentences(design, population, supporting numbers)
Summary · context
This work aimed to evaluate the effects of CAR on diet-induced MASLD in rats.
Summary · context
After, the animals were redistributed to begin the treatment with CAR (4 weeks): Co (n = 6), Co + CAR (n = 6), MASLD (n = 6), and MASLD + CAR (n = 6), administered intraperitoneally (250 mg/kg).
Report a problemFND-3814795402
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with MASLD, carnosine reduced plasma cholesterol compared with untreated MASLD rats.
In plain wordsIn rats with MASLD, carnosine reduced blood cholesterol compared with untreated MASLD rats.
Peptide
L-carnosine
Outcome
DecreasePlasma cholesterol
Study
ratn = 12
Diet-induced MASLD in male Wistar rats
Comparator
Untreated MASLD group
Outcome group
Lipids · Metabolic and weight
Studied dose
250 mg/kg · intraperitoneal · 4 weeksAs given in this study (rat).
Source sentences
Summary
CAR attenuated plasma and hepatic triglyceride and cholesterol levels, hepatic steatosis, CD68⁺ macrophages, and hepatic oxidative markers, in addition to increasing HDL cholesterol levels and PPAR-α, compared to the untreated MASLD group.
2 context sentences(design, population, supporting numbers)
Summary · context
This work aimed to evaluate the effects of CAR on diet-induced MASLD in rats.
Summary · context
After, the animals were redistributed to begin the treatment with CAR (4 weeks): Co (n = 6), Co + CAR (n = 6), MASLD (n = 6), and MASLD + CAR (n = 6), administered intraperitoneally (250 mg/kg).
Report a problemFND-3814795403
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with MASLD, carnosine reduced hepatic cholesterol compared with untreated MASLD rats.
In plain wordsIn rats with MASLD, carnosine reduced liver cholesterol compared with untreated MASLD rats.
Peptide
L-carnosine
Outcome
DecreaseHepatic cholesterol
Study
ratn = 12
Diet-induced MASLD in male Wistar rats
Comparator
Untreated MASLD group
Outcome group
Liver fat and liver function · Liver
Studied dose
250 mg/kg · intraperitoneal · 4 weeksAs given in this study (rat).
Source sentences
Summary
CAR attenuated plasma and hepatic triglyceride and cholesterol levels, hepatic steatosis, CD68⁺ macrophages, and hepatic oxidative markers, in addition to increasing HDL cholesterol levels and PPAR-α, compared to the untreated MASLD group.
2 context sentences(design, population, supporting numbers)
Summary · context
This work aimed to evaluate the effects of CAR on diet-induced MASLD in rats.
Summary · context
After, the animals were redistributed to begin the treatment with CAR (4 weeks): Co (n = 6), Co + CAR (n = 6), MASLD (n = 6), and MASLD + CAR (n = 6), administered intraperitoneally (250 mg/kg).
Report a problemFND-3814795404
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with MASLD, carnosine reduced hepatic steatosis compared with untreated MASLD rats.
In plain wordsIn rats with MASLD, carnosine reduced liver fat accumulation compared with untreated MASLD rats.
Peptide
L-carnosine
Outcome
DecreaseHepatic steatosis
Study
ratn = 12
Diet-induced MASLD in male Wistar rats
Comparator
Untreated MASLD group
Outcome group
Liver fat and liver function · Liver
Studied dose
250 mg/kg · intraperitoneal · 4 weeksAs given in this study (rat).
Source sentences
Summary
CAR attenuated plasma and hepatic triglyceride and cholesterol levels, hepatic steatosis, CD68⁺ macrophages, and hepatic oxidative markers, in addition to increasing HDL cholesterol levels and PPAR-α, compared to the untreated MASLD group.
2 context sentences(design, population, supporting numbers)
Summary · context
This work aimed to evaluate the effects of CAR on diet-induced MASLD in rats.
Summary · context
After, the animals were redistributed to begin the treatment with CAR (4 weeks): Co (n = 6), Co + CAR (n = 6), MASLD (n = 6), and MASLD + CAR (n = 6), administered intraperitoneally (250 mg/kg).
Report a problemFND-3814795405
06AnimalAnimal study (in vivo)Mechanism
In rats with MASLD, carnosine reduced CD68-positive macrophages compared with untreated MASLD rats.
In plain wordsIn rats with MASLD, carnosine reduced liver macrophages compared with untreated MASLD rats.
Peptide
L-carnosine
Outcome
DecreaseCD68+ macrophages
Study
ratn = 12
Diet-induced MASLD in male Wistar rats
Comparator
Untreated MASLD group
Outcome group
Inflammation markers · Liver
Studied dose
250 mg/kg · intraperitoneal · 4 weeksAs given in this study (rat).
Source sentences
Summary
CAR attenuated plasma and hepatic triglyceride and cholesterol levels, hepatic steatosis, CD68⁺ macrophages, and hepatic oxidative markers, in addition to increasing HDL cholesterol levels and PPAR-α, compared to the untreated MASLD group.
2 context sentences(design, population, supporting numbers)
Summary · context
This work aimed to evaluate the effects of CAR on diet-induced MASLD in rats.
Summary · context
After, the animals were redistributed to begin the treatment with CAR (4 weeks): Co (n = 6), Co + CAR (n = 6), MASLD (n = 6), and MASLD + CAR (n = 6), administered intraperitoneally (250 mg/kg).
Report a problemFND-3814795406
07AnimalAnimal study (in vivo)Mechanism
In rats with MASLD, carnosine reduced hepatic oxidative markers compared with untreated MASLD rats.
In plain wordsIn rats with MASLD, carnosine reduced liver oxidative markers compared with untreated MASLD rats.
Peptide
L-carnosine
Outcome
DecreaseHepatic oxidative markers
Study
ratn = 12
Diet-induced MASLD in male Wistar rats
Comparator
Untreated MASLD group
Outcome group
Oxidative stress · Liver
Studied dose
250 mg/kg · intraperitoneal · 4 weeksAs given in this study (rat).
Source sentences
Summary
CAR attenuated plasma and hepatic triglyceride and cholesterol levels, hepatic steatosis, CD68⁺ macrophages, and hepatic oxidative markers, in addition to increasing HDL cholesterol levels and PPAR-α, compared to the untreated MASLD group.
2 context sentences(design, population, supporting numbers)
Summary · context
This work aimed to evaluate the effects of CAR on diet-induced MASLD in rats.
Summary · context
After, the animals were redistributed to begin the treatment with CAR (4 weeks): Co (n = 6), Co + CAR (n = 6), MASLD (n = 6), and MASLD + CAR (n = 6), administered intraperitoneally (250 mg/kg).
Report a problemFND-3814795407
08AnimalAnimal study (in vivo)Efficacy outcome
In rats with MASLD, carnosine increased HDL cholesterol compared with untreated MASLD rats.
In plain wordsIn rats with MASLD, carnosine increased HDL cholesterol compared with untreated MASLD rats.
Peptide
L-carnosine
Outcome
IncreaseHDL cholesterol
Study
ratn = 12
Diet-induced MASLD in male Wistar rats
Comparator
Untreated MASLD group
Outcome group
Lipids · Metabolic and weight
Studied dose
250 mg/kg · intraperitoneal · 4 weeksAs given in this study (rat).
Source sentences
Summary
CAR attenuated plasma and hepatic triglyceride and cholesterol levels, hepatic steatosis, CD68⁺ macrophages, and hepatic oxidative markers, in addition to increasing HDL cholesterol levels and PPAR-α, compared to the untreated MASLD group.
2 context sentences(design, population, supporting numbers)
Summary · context
This work aimed to evaluate the effects of CAR on diet-induced MASLD in rats.
Summary · context
After, the animals were redistributed to begin the treatment with CAR (4 weeks): Co (n = 6), Co + CAR (n = 6), MASLD (n = 6), and MASLD + CAR (n = 6), administered intraperitoneally (250 mg/kg).
Report a problemFND-3814795408
09AnimalAnimal study (in vivo)Mechanism
In rats with MASLD, carnosine increased PPAR-alpha compared with untreated MASLD rats.
In plain wordsIn rats with MASLD, carnosine increased PPAR-alpha compared with untreated MASLD rats.
Peptide
L-carnosine
Outcome
IncreasePPAR-alpha
Study
ratn = 12
Diet-induced MASLD in male Wistar rats
Comparator
Untreated MASLD group
Outcome group
Receptor activity and mechanism · Liver
Studied dose
250 mg/kg · intraperitoneal · 4 weeksAs given in this study (rat).
Source sentences
Summary
CAR attenuated plasma and hepatic triglyceride and cholesterol levels, hepatic steatosis, CD68⁺ macrophages, and hepatic oxidative markers, in addition to increasing HDL cholesterol levels and PPAR-α, compared to the untreated MASLD group.
2 context sentences(design, population, supporting numbers)
Summary · context
This work aimed to evaluate the effects of CAR on diet-induced MASLD in rats.
Summary · context
After, the animals were redistributed to begin the treatment with CAR (4 weeks): Co (n = 6), Co + CAR (n = 6), MASLD (n = 6), and MASLD + CAR (n = 6), administered intraperitoneally (250 mg/kg).
Report a problemFND-3814795409

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

Keywords

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