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Study · Animal study (in vivo) · rat · 2010

8 results

Carnosine supplementation protects rat brain tissue against ethanol-induced oxidative stress.

Ozel Turkcu U, Bilgihan A, Biberoglu G, Mertoglu Caglar O

Molecular and cellular biochemistry3 Jan 2010Cited by 20 (Europe PMC)

PMID20047045 (opens in a new tab)DOI10.1007/s11010-009-0369-x (opens in a new tab)PepBankPUB-20047045
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, carnosine treatment increased brain carnosine levels compared with control animals.

    In plain wordsIn rats, carnosine treatment increased brain carnosine levels compared with controls.

    Peptide
    L-carnosine
    Outcome
    IncreaseBrain carnosine levels
    Study

    ratn = 20

    Male rats
    Comparator
    Control
    Outcome group
    Pharmacokinetics · Nervous system and cognition
    Studied dose
    1 mg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    Endogenous CAR levels in the rat brain tissue specimens were significantly increased in the CAR and EtOH groups when compared to the control animals.
    2 context sentences
    Summary · context
    Forty male rats were divided equally into four groups as control, carnosine (CAR), ethanol (EtOH), and ethanol plus carnosine (EtOH + CAR).
    Summary · context
    Rats in the control group (n = 10) were injected intraperitoneally (i.p.) with 0.9% saline; EtOH group (n = 10) with 2 g/kg/day ethanol, CAR group (n = 10) received carnosine at a dose of 1 mg/kg/day and EtOH + CAR group (n = 10) received carnosine (orally) and ethanol (i.p.).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ethanol-exposed rats, carnosine was associated with lower brain MDA than ethanol alone.

    In plain wordsIn ethanol-exposed rats, carnosine was associated with lower brain MDA than ethanol alone.

    Peptide
    L-carnosine
    Outcome
    DecreaseBrain MDA under ethanol exposure
    Study

    ratn = 20

    Male rats
    Comparator
    Ethanol alone
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    1 mg/kg/day · oralAs given in this study (rat).

    Source sentences

    Summary
    MDA and PCO levels in the EtOH group were significantly increased as compared to the other groups (P < 0.05).
    2 context sentences
    Summary · context
    Forty male rats were divided equally into four groups as control, carnosine (CAR), ethanol (EtOH), and ethanol plus carnosine (EtOH + CAR).
    Summary · context
    Rats in the control group (n = 10) were injected intraperitoneally (i.p.) with 0.9% saline; EtOH group (n = 10) with 2 g/kg/day ethanol, CAR group (n = 10) received carnosine at a dose of 1 mg/kg/day and EtOH + CAR group (n = 10) received carnosine (orally) and ethanol (i.p.).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ethanol-exposed rats, carnosine was associated with lower brain protein carbonyl levels than ethanol alone.

    In plain wordsIn ethanol-exposed rats, carnosine was associated with lower brain protein carbonyl levels than ethanol alone.

    Peptide
    L-carnosine
    Outcome
    DecreaseBrain protein carbonyl under ethanol exposure
    Study

    ratn = 20

    Male rats
    Comparator
    Ethanol alone
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    1 mg/kg/day · oralAs given in this study (rat).

    Source sentences

    Summary
    MDA and PCO levels in the EtOH group were significantly increased as compared to the other groups (P < 0.05).
    2 context sentences
    Summary · context
    Forty male rats were divided equally into four groups as control, carnosine (CAR), ethanol (EtOH), and ethanol plus carnosine (EtOH + CAR).
    Summary · context
    Rats in the control group (n = 10) were injected intraperitoneally (i.p.) with 0.9% saline; EtOH group (n = 10) with 2 g/kg/day ethanol, CAR group (n = 10) received carnosine at a dose of 1 mg/kg/day and EtOH + CAR group (n = 10) received carnosine (orally) and ethanol (i.p.).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, brain MDA was lower with carnosine alone than with ethanol alone.

    In plain wordsIn rats, brain MDA was lower with carnosine alone than with ethanol alone.

    Peptide
    L-carnosine
    Outcome
    DecreaseBrain MDA with carnosine alone
    Study

    ratn = 20

    Male rats
    Comparator
    Ethanol alone
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    1 mg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    MDA and PCO levels in the EtOH group were significantly increased as compared to the other groups (P < 0.05).
    2 context sentences
    Summary · context
    Forty male rats were divided equally into four groups as control, carnosine (CAR), ethanol (EtOH), and ethanol plus carnosine (EtOH + CAR).
    Summary · context
    Rats in the control group (n = 10) were injected intraperitoneally (i.p.) with 0.9% saline; EtOH group (n = 10) with 2 g/kg/day ethanol, CAR group (n = 10) received carnosine at a dose of 1 mg/kg/day and EtOH + CAR group (n = 10) received carnosine (orally) and ethanol (i.p.).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, brain protein carbonyl levels were lower with carnosine alone than with ethanol alone.

    In plain wordsIn rats, brain protein carbonyl levels were lower with carnosine alone than with ethanol alone.

    Peptide
    L-carnosine
    Outcome
    DecreaseBrain protein carbonyl with carnosine alone
    Study

    ratn = 20

    Male rats
    Comparator
    Ethanol alone
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    1 mg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    MDA and PCO levels in the EtOH group were significantly increased as compared to the other groups (P < 0.05).
    2 context sentences
    Summary · context
    Forty male rats were divided equally into four groups as control, carnosine (CAR), ethanol (EtOH), and ethanol plus carnosine (EtOH + CAR).
    Summary · context
    Rats in the control group (n = 10) were injected intraperitoneally (i.p.) with 0.9% saline; EtOH group (n = 10) with 2 g/kg/day ethanol, CAR group (n = 10) received carnosine at a dose of 1 mg/kg/day and EtOH + CAR group (n = 10) received carnosine (orally) and ethanol (i.p.).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, carnosine alone reduced brain MDA compared with controls.

    In plain wordsIn rats, carnosine alone reduced brain MDA compared with controls.

    Peptide
    L-carnosine
    Outcome
    DecreaseBrain MDA
    Study

    ratn = 20

    Male rats
    Comparator
    Control
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    1 mg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    CAR treatment also decreased MDA levels in the CAR group as compared to the control group.
    2 context sentences
    Summary · context
    Forty male rats were divided equally into four groups as control, carnosine (CAR), ethanol (EtOH), and ethanol plus carnosine (EtOH + CAR).
    Summary · context
    Rats in the control group (n = 10) were injected intraperitoneally (i.p.) with 0.9% saline; EtOH group (n = 10) with 2 g/kg/day ethanol, CAR group (n = 10) received carnosine at a dose of 1 mg/kg/day and EtOH + CAR group (n = 10) received carnosine (orally) and ethanol (i.p.).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats, ethanol plus carnosine increased brain SOD activity compared with controls.

    In plain wordsIn rats, ethanol plus carnosine increased brain SOD activity compared with controls.

    Peptide
    L-carnosine
    Outcome
    IncreaseBrain SOD activity with ethanol
    Study

    ratn = 20

    Male rats
    Comparator
    Control
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    1 mg/kg/day · oralAs given in this study (rat).

    Source sentences

    Summary
    Increased SOD activities were obtained in the EtOH + CAR group as compared to the control (P < 0.05).
    2 context sentences
    Summary · context
    Forty male rats were divided equally into four groups as control, carnosine (CAR), ethanol (EtOH), and ethanol plus carnosine (EtOH + CAR).
    Summary · context
    Rats in the control group (n = 10) were injected intraperitoneally (i.p.) with 0.9% saline; EtOH group (n = 10) with 2 g/kg/day ethanol, CAR group (n = 10) received carnosine at a dose of 1 mg/kg/day and EtOH + CAR group (n = 10) received carnosine (orally) and ethanol (i.p.).
  8. 08AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, ethanol plus carnosine increased brain carnosine levels compared with controls.

    In plain wordsIn rats, ethanol plus carnosine increased brain carnosine levels compared with controls.

    Peptide
    L-carnosine
    Outcome
    IncreaseBrain carnosine levels with ethanol
    Study

    ratn = 20

    Male rats
    Comparator
    Control
    Outcome group
    Pharmacokinetics · Nervous system and cognition
    Studied dose
    1 mg/kg/day · oralAs given in this study (rat).

    Source sentences

    Summary
    CAR levels in the rat brain were significantly increased in the CAR, EtOH and CAR + EtOH groups when compared to the control animals.
    2 context sentences
    Summary · context
    Forty male rats were divided equally into four groups as control, carnosine (CAR), ethanol (EtOH), and ethanol plus carnosine (EtOH + CAR).
    Summary · context
    Rats in the control group (n = 10) were injected intraperitoneally (i.p.) with 0.9% saline; EtOH group (n = 10) with 2 g/kg/day ethanol, CAR group (n = 10) received carnosine at a dose of 1 mg/kg/day and EtOH + CAR group (n = 10) received carnosine (orally) and ethanol (i.p.).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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