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Study · Animal study (in vivo) · rat · 2011

6 results

Oral carnosine supplementation prevents vascular damage in experimental diabetic retinopathy.

Pfister F, Riedl E, Wang Q, vom Hagen F, Deinzer M, Harmsen MC, Molema G, Yard B, Feng Y, Hammes HP

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology16 Aug 2011Cited by 81 (Europe PMC)

PMID21865855 (opens in a new tab)DOI10.1159/000331721 (opens in a new tab)PepBankPUB-21865855
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, oral carnosine prevented retinal vascular damage after 6 months of experimental hyperglycemia.

    In plain wordsIn diabetic rats, oral carnosine prevented retinal blood vessel damage.

    Peptide
    L-carnosine
    Outcome
    DecreaseRetinal vascular damage
    Study

    ratn: not reported in source

    STZ-induced diabetic Wistar rats
    Outcome group
    Neuroprotection · Eye
    Studied dose
    1g/kg body weight/day · oral · 6 monthsAs given in this study (rat).

    Source sentences

    Summary
    Oral carnosine treatment prevented retinal vascular damage after 6 months of experimental hyperglycemia.
    1 context sentence
    Summary · context
    STZ-induced diabetic Wistar rats were orally treated with carnosine (1g/kg body weight/day).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, retinal protection with carnosine was not associated with ROS inhibition.

    In plain wordsIn diabetic rats, carnosine's retinal protection did not involve ROS inhibition.

    Peptide
    L-carnosine
    Outcome
    Not applicableROS inhibition
    Study

    ratn: not reported in source

    STZ-induced diabetic Wistar rats
    Outcome group
    Inflammation markers · Eye
    Studied dose
    1g/kg body weight/day · oralAs given in this study (rat).

    Source sentences

    Summary
    The protection was not caused by ROS- or AGE-inhibition, but associated with a significant induction of Hsp27 in activated glial cells and normalization of increased Ang-2 levels in diabetic retinas.
    1 context sentence
    Summary · context
    STZ-induced diabetic Wistar rats were orally treated with carnosine (1g/kg body weight/day).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, retinal protection with carnosine was not associated with AGE inhibition.

    In plain wordsIn diabetic rats, carnosine's retinal protection did not involve AGE inhibition.

    Peptide
    L-carnosine
    Outcome
    Not applicableAGE inhibition
    Study

    ratn: not reported in source

    STZ-induced diabetic Wistar rats
    Outcome group
    Inflammation markers · Eye
    Studied dose
    1g/kg body weight/day · oralAs given in this study (rat).

    Source sentences

    Summary
    The protection was not caused by ROS- or AGE-inhibition, but associated with a significant induction of Hsp27 in activated glial cells and normalization of increased Ang-2 levels in diabetic retinas.
    1 context sentence
    Summary · context
    STZ-induced diabetic Wistar rats were orally treated with carnosine (1g/kg body weight/day).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine-associated retinal protection accompanied significant Hsp27 induction in activated glial cells.

    In plain wordsIn diabetic rats, carnosine-associated retinal protection accompanied increased Hsp27 in activated glial cells.

    Peptide
    L-carnosine
    Outcome
    IncreaseHsp27 induction
    Study

    ratn: not reported in source

    STZ-induced diabetic Wistar rats
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    1g/kg body weight/day · oralAs given in this study (rat).

    Source sentences

    Summary
    The protection was not caused by ROS- or AGE-inhibition, but associated with a significant induction of Hsp27 in activated glial cells and normalization of increased Ang-2 levels in diabetic retinas.
    1 context sentence
    Summary · context
    STZ-induced diabetic Wistar rats were orally treated with carnosine (1g/kg body weight/day).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine-associated retinal protection accompanied normalization of increased retinal Ang-2 levels.

    In plain wordsIn diabetic rats, carnosine-associated retinal protection accompanied normalization of elevated Ang-2 levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseAng-2 levels
    Study

    ratn: not reported in source

    STZ-induced diabetic Wistar rats
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    1g/kg body weight/day · oralAs given in this study (rat).

    Source sentences

    Summary
    The protection was not caused by ROS- or AGE-inhibition, but associated with a significant induction of Hsp27 in activated glial cells and normalization of increased Ang-2 levels in diabetic retinas.
    1 context sentence
    Summary · context
    STZ-induced diabetic Wistar rats were orally treated with carnosine (1g/kg body weight/day).
  6. 06AnimalAnimal study (in vivo)Safety outcome

    In carnosine-treated diabetic rats, retinal photoreceptor numbers were significantly reduced.

    In plain wordsIn diabetic rats treated with carnosine, retinal photoreceptor numbers decreased.

    Peptide
    L-carnosine
    Outcome
    DecreasePhotoreceptor numbers
    Study

    ratn: not reported in source

    STZ-induced diabetic Wistar rats
    Outcome group
    Adverse events · Eye
    Studied dose
    1g/kg body weight/day · oralAs given in this study (rat).

    Source sentences

    Summary
    A significant reduction of photoreceptors in retinas of carnosine treated animals was noted.
    1 context sentence
    Summary · context
    STZ-induced diabetic Wistar rats were orally treated with carnosine (1g/kg body weight/day).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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