AICAR (acadesine) studies: 330 papers with results
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- Involvement of a phosphorylation-mediated pathway to regulate the function of NSPL1 in exercise.
Ikemoto T · The Journal of veterinary medical science · 2011
Animal study (in vivo) · mouse · 2 results
- 5-aminoimidazole-4-carboxamide riboside administration and purine release from the hypoxic/hypotensive rat cerebral cortex.
Walter GA · Neurochemistry international · 1989
Animal study (in vivo) · rat · 7 results
- Sacubitril/Valsartan Ameliorates Inflammation and Oxidative Stress in Hypertensive Heart Disease by Upregulating CAMKK2 Protein and Modulating the AMPK/AKT/GSK-3β Axis.
Yang YJ · The Kaohsiung journal of medical sciences · 2026
Animal study (in vivo) · rat · 4 results
- AICAR Administration Attenuates Hemorrhagic Hyperglycemia and Lowers Oxygen Debt in Anesthetized Male Rabbits.
Huang Y · Frontiers in physiology · 2017
Animal study (in vivo) · rabbit · 11 results
- Hepassocin prevents age-related liver senescence and facilitates liver regeneration by activating AMPK.
Yang Y · Signal transduction and targeted therapy · 2026
Animal study (in vivo) · mouse · 2 results
- AICAR improves depression-like behaviors and is associated with hippocampal AMPK activation and modulation of neurogenesis and neuroinflammation in a microbiota disruption model.
Takahashi K · Neurochemistry international · 2026
Animal study (in vivo) · mouse · 14 results
- Nicorandil ameliorates cardiac microcirculation in hypertensive myocardial infarction via LKB1/AMPK signaling activation.
Wang W · Pakistan journal of pharmaceutical sciences · 2026
Animal study (in vivo) · rat · 5 results
- Ketamine ameliorates postpartum depression-like behaviors in rats exposed to sevoflurane during pregnancy through the AMPK/SIRT1/NLRP3 pathway.
Xue H · Journal of affective disorders · 2026
Animal study (in vivo) · rat · 11 results
- Electroacupuncture alleviates inflammatory pain through AMPK-autophagy signaling and suppression of iNOS and IL-1β in inflamed tissues.
Xiang H · Molecular pain · 2026
Animal study (in vivo) · mouse · 3 results
- Activated AMPK attenuates cardiac hypertrophy in rats through increas- ing myocardial fatty acid oxidation
Yin Ran
Animal study (in vivo) · rat · 7 results
- Regulation of autophagy in human skeletal muscle: effects of exercise, exercise training and insulin stimulation.
Fritzen AM · The Journal of physiology · 2016
Other design · mouse · 1 result
- Metformin prevents the pathological browning of subcutaneous white adipose tissue.
Auger C · Molecular metabolism · 2019
Other design · mouse · 1 result
- AMPK Activation by 5-Amino-4-Imidazole Carboxamide Riboside-1-β-D-Ribofuranoside Attenuates Alkali Injury-Induced Corneal Fibrosis.
Nuwormegbe SA · Investigative ophthalmology & visual science · 2020
Other design · mouse · 3 results
- The ameliorating effect of exercise on long-term memory impairment and dendritic retraction via the mild activation of AMP-activated protein kinase in chronically stressed hippocampal CA1 neurons.
Leem YH · Journal of exercise nutrition & biochemistry · 2018
Other design · mouse · 1 result
- Exogenous pyruvate restores mitochondrial bioenergetics by synergizing with the AMPK-mTOR-SIRT3 pathway to alleviate sepsis-associated acute kidney injury.
Wang Y · Chemico-biological interactions · 2026
Other design · 11 results
- GPR75 knockdown alleviates mitochondrial dysfunction in retinal ganglion cells via AMPK pathway in diabetic mice.
Liu M · Biochemical pharmacology · 2026
Other design · 3 results
- Acadesine and myocardial protection. Studies of time of administration and dose-response relations in the rat.
Galiñanes M · Circulation · 1992
Ex vivo tissue · rat · 16 results
- Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle.
Terada S · Biochemical and biophysical research communications · 2002
Ex vivo tissue · rat · 1 result
- Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction.
Li J · Journal of molecular and cellular cardiology · 2015
Ex vivo tissue · rat · 16 results
- Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport.
Chen HC · The Journal of biological chemistry · 2002
Ex vivo tissue · rat · 18 results
- Effects of acute bouts of running and swimming exercise on PGC-1alpha protein expression in rat epitrochlearis and soleus muscle.
Terada S · American journal of physiology. Endocrinology and metabolism · 2004
Ex vivo tissue · rat · 2 results
- UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase.
Zhou M · American journal of physiology. Endocrinology and metabolism · 2000
Ex vivo tissue · rat · 2 results
- Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction.
Paiva MA · Cardiovascular drugs and therapy · 2010
Ex vivo tissue · rat · 2 results
- AMP kinase activation ameliorates insulin resistance induced by free fatty acids in rat skeletal muscle.
Olsen GS · American journal of physiology. Endocrinology and metabolism · 2002
Ex vivo tissue · rat · 9 results
- Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise.
Klein DK · American journal of physiology. Endocrinology and metabolism · 2007
Ex vivo tissue · mouse · 2 results
- Possible involvement of AMPK in acute exercise-induced expression of monocarboxylate transporters MCT1 and MCT4 mRNA in fast-twitch skeletal muscle.
Takimoto M · Metabolism: clinical and experimental · 2013
Ex vivo tissue · rat · 5 results
- Activation of AMPK in human fetal membranes alleviates infection-induced expression of pro-inflammatory and pro-labour mediators.
Lim R · Placenta · 2015
Ex vivo tissue · 3 results
- Does long-term metformin treatment increase cardiac lipoprotein lipase?
Hauton D · Metabolism: clinical and experimental · 2011
Ex vivo tissue · rat · 6 results
- Treatment with AICAR inhibits blastocyst development, trophectoderm differentiation and tight junction formation and function in mice.
Calder MD · Molecular human reproduction · 2017
Ex vivo tissue · mouse · 14 results
- Prior treatment with the AMPK activator AICAR induces subsequently enhanced glucose uptake in isolated skeletal muscles from 24-month-old rats.
Oki K · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2018
Ex vivo tissue · rat · 6 results
- Donor pretreatment with adenosine monophosphate-activated protein kinase activator protects cardiac grafts from cold ischaemia/reperfusion injury.
Yang C · European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2016
Ex vivo tissue · rat · 8 results
- AICAR reverses ketone body mediated insulin resistance in isolated oxidative muscle.
Ivarsson N · Biochemical and biophysical research communications · 2011
Ex vivo tissue · mouse · 3 results
- Acute bout of exercise downregulates thioredoxin-interacting protein expression in rat contracting skeletal muscles.
Ra SG · Physiological reports · 2020
Ex vivo tissue · rat · 2 results
- Effects of AMPK activation and combined treatment with AMPK activators and somatostatin on hormone secretion and cell growth in cultured GH-secreting pituitary tumor cells.
Tulipano G · Molecular and cellular endocrinology · 2013
In vitro (cells) · rat · 15 results
- AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress.
Terai K · Molecular and cellular biology · 2005
In vitro (cells) · rat · 4 results
- Skeletal muscle NAMPT is induced by exercise in humans.
Costford SR · American journal of physiology. Endocrinology and metabolism · 2010
In vitro (cells) · 3 results
- Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro.
Petersen EW · American journal of physiology. Endocrinology and metabolism · 2005
In vitro (cells) · 1 result
- Metformin improves obesity-associated inflammation by altering macrophages polarization.
Jing Y · Molecular and cellular endocrinology · 2018
In vitro (cells) · mouse · 3 results
- Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism.
Salvadó L · Diabetologia · 2013
In vitro (cells) · mouse · 1 result
- Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy.
Kim J · Molecular endocrinology (Baltimore, Md.) · 2008
In vitro (cells) · rat · 1 result
- Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
Liu X · Metabolism: clinical and experimental · 2020
In vitro (cells) · 5 results
- Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMP-activated protein kinase.
Stuck BJ · The Journal of biological chemistry · 2008
In vitro (cells) · rat · 4 results
- Chicoric Acid Ameliorates Nonalcoholic Fatty Liver Disease via the AMPK/Nrf2/NFκB Signaling Pathway and Restores Gut Microbiota in High-Fat-Diet-Fed Mice.
Ding X · Oxidative medicine and cellular longevity · 2020
In vitro (cells) · 3 results
- AMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and Function.
Kang SW · PloS one · 2016
In vitro (cells) · rat · 10 results
- Sestrin2 protects against cholestatic liver injury by inhibiting endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis.
Han D · Experimental & molecular medicine · 2022
In vitro (cells) · 1 result
- Berberine attenuates apoptosis in rat retinal Müller cells stimulated with high glucose via enhancing autophagy and the AMPK/mTOR signaling.
Chen H · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2018
In vitro (cells) · rat · 1 result
- The truncated splice variants, NT-PGC-1α and PGC-1α4, increase with both endurance and resistance exercise in human skeletal muscle.
Ydfors M · Physiological reports · 2013
In vitro (cells) · 2 results
- AICAR, an AMPK activator, protects against cisplatin-induced acute kidney injury through the JAK/STAT/SOCS pathway.
Tsogbadrakh B · Biochemical and biophysical research communications · 2019
In vitro (cells) · rat · 4 results
- 4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells.
Duan P · Toxicology letters · 2017
In vitro (cells) · 2 results
- Activation of AMPK attenuates lipopolysaccharide-impaired integrity and function of blood-brain barrier in human brain microvascular endothelial cells.
Zhao Z · Experimental and molecular pathology · 2014
In vitro (cells) · 5 results