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Study · Animal study (in vivo) · mouse · 2011

2 results

Involvement of a phosphorylation-mediated pathway to regulate the function of NSPL1 in exercise.

Ikemoto T, Suzuki M, Onoe H

The Journal of veterinary medical science19 Jan 2011Cited by 2 (Europe PMC)

PMID21258182 (opens in a new tab)DOI10.1292/jvms.10-0543 (opens in a new tab)PepBankPUB-21258182
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In wild-type mouse muscle, p-resin adsorbed membrane sk-NSPL1 after AICAR administration.

    In plain wordsIn mice, a resin that binds phosphorylated proteins captured membrane sk-NSPL1 after AICAR treatment.

    Peptide
    AICAR (acadesine)
    Outcome
    Not applicableMembrane sk-NSPL1 adsorption onto p-resin
    Study

    mousen: not reported in source

    Wild-type and sk-NSPL1-deficient skeletal muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    P-resin adsorbed sk-NSPL1 in the membrane fraction from wild-type muscle after exercise and AICAR administration.

Studies that did not test the peptide alone1

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 02AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In sk-NSPL1-deficient mice, the effect of AICAR on blood glucose was greatly diminished.

    In plain wordsIn mutant mice, AICAR had a smaller effect on blood glucose than in normal mice.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseAICAR effect on blood glucose in mutants
    Study

    mousen: not reported in source

    Wild-type and sk-NSPL1-deficient skeletal muscle
    Comparator
    Wild-type mice
    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    On the other hand, the effect of 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR), which is an activator of AMPK, in blood glucose was greatly diminished in mutant mice.
    1 context sentence
    Summary · context
    We investigated the levels of phosphorylation in proteins that are thought to be involved in exercise in wild-type and sk-NSPL1-deficient muscles with specific antibodies and phosphate-metal affinity chromatography resin (p-resin).

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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