Skip to content

Study · Animal study (in vivo) · rat · 1989

7 results

5-aminoimidazole-4-carboxamide riboside administration and purine release from the hypoxic/hypotensive rat cerebral cortex.

Walter GA, Phillis JW

Neurochemistry international1 Jan 1989Cited by 2 (Europe PMC)

PMID20504523 (opens in a new tab)DOI10.1016/0197-0186(89)90167-8 (opens in a new tab)PepBankPUB-20504523
Publisher pagePubMedAsk about this study
Jump to 7 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, intraperitoneal AICAriboside rapidly reached cortical superfusate concentrations up to 9 ?M and maintained them for 90 min.

    In plain wordsIn rats, injected AICAriboside rapidly entered cortical fluid and remained there for 90 min.

    Peptide
    AICAR (acadesine)
    Outcome
    Not applicableCortical superfusate exposure after intraperitoneal dosing
    Study

    ratn: not reported in source

    cerebral cortex
    Outcome group
    Pharmacokinetics · Nervous system and cognition
    Studied dose
    500 mg/kg · intraperitoneal · 90 minAs given in this study (rat).

    Measurements

    Concentration
    ≤ 9 ?M
    cortical superfusate

    Source sentences

    Summary
    Following its intraperitoneal administration AICAriboside appeared rapidly in the cortical superfusates at concentrations of up to 9 ?M and remained at this level for a 90 min period.
    2 context sentences
    Summary · context
    The effects of the purine precursor 5-aminoimidazole-4-carboxamide riboside (AICAriboside) on the release of purines from cerebral cortices of normoxic and hypoxic/hypotensive rats was studied with the cortical cup technique.
    Summary · context
    AICAriboside was administered either intravascularly (50 mg/kg) or intraperitoneally (500 mg/kg) to ascertain whether this agent can be used to enhance adenosine levels in the cerebral cortical interstitial fluid.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, intravascular AICAriboside peaked at 2 ?M in cortical superfusates and then declined rapidly.

    In plain wordsIn rats, AICAriboside levels in cortical fluid peaked and then fell rapidly after intravascular dosing.

    Peptide
    AICAR (acadesine)
    Outcome
    Not applicableCortical superfusate exposure after intravascular dosing
    Study

    ratn: not reported in source

    cerebral cortex
    Outcome group
    Pharmacokinetics · Nervous system and cognition
    Studied dose
    50 mg/kg · intravascularAs given in this study (rat).

    Measurements

    Peak concentration
    2 ?M
    cortical superfusate

    Source sentences

    Summary
    After intravascular administration, AICAriboside levels peaked at 2 ?M, and then declined rapidly.
    2 context sentences
    Summary · context
    The effects of the purine precursor 5-aminoimidazole-4-carboxamide riboside (AICAriboside) on the release of purines from cerebral cortices of normoxic and hypoxic/hypotensive rats was studied with the cortical cup technique.
    Summary · context
    AICAriboside was administered either intravascularly (50 mg/kg) or intraperitoneally (500 mg/kg) to ascertain whether this agent can be used to enhance adenosine levels in the cerebral cortical interstitial fluid.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, AICAriboside did not increase basal cortical superfusate adenosine levels.

    In plain wordsIn rats, AICAriboside did not increase basal adenosine in cortical fluid.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeBasal adenosine levels
    Study

    ratn: not reported in source

    cerebral cortex
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No increases in basal (normoxic) or hypoxia-elicited adenosine levels in the cortical superfusates were observed.
    2 context sentences
    Summary · context
    The effects of the purine precursor 5-aminoimidazole-4-carboxamide riboside (AICAriboside) on the release of purines from cerebral cortices of normoxic and hypoxic/hypotensive rats was studied with the cortical cup technique.
    Summary · context
    AICAriboside was administered either intravascularly (50 mg/kg) or intraperitoneally (500 mg/kg) to ascertain whether this agent can be used to enhance adenosine levels in the cerebral cortical interstitial fluid.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, AICAriboside did not increase hypoxia-elicited cortical superfusate adenosine levels.

    In plain wordsIn rats, AICAriboside did not increase adenosine released during low oxygen exposure.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeHypoxia-elicited adenosine levels
    Study

    ratn: not reported in source

    cerebral cortex
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No increases in basal (normoxic) or hypoxia-elicited adenosine levels in the cortical superfusates were observed.
    2 context sentences
    Summary · context
    The effects of the purine precursor 5-aminoimidazole-4-carboxamide riboside (AICAriboside) on the release of purines from cerebral cortices of normoxic and hypoxic/hypotensive rats was studied with the cortical cup technique.
    Summary · context
    AICAriboside was administered either intravascularly (50 mg/kg) or intraperitoneally (500 mg/kg) to ascertain whether this agent can be used to enhance adenosine levels in the cerebral cortical interstitial fluid.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, AICAriboside increased basal and hypoxia-evoked cortical hypoxanthine levels.

    In plain wordsIn rats, AICAriboside increased cortical hypoxanthine levels under basal and low oxygen conditions.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseHypoxanthine levels
    Study

    ratn: not reported in source

    cerebral cortex
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Increases did occur in the basal and hypoxia-evoked levels of hypoxanthine, xanthine and, especially, of uric acid.
    2 context sentences
    Summary · context
    The effects of the purine precursor 5-aminoimidazole-4-carboxamide riboside (AICAriboside) on the release of purines from cerebral cortices of normoxic and hypoxic/hypotensive rats was studied with the cortical cup technique.
    Summary · context
    AICAriboside was administered either intravascularly (50 mg/kg) or intraperitoneally (500 mg/kg) to ascertain whether this agent can be used to enhance adenosine levels in the cerebral cortical interstitial fluid.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats, AICAriboside increased basal and hypoxia-evoked cortical xanthine levels.

    In plain wordsIn rats, AICAriboside increased cortical xanthine levels under basal and low oxygen conditions.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseXanthine levels
    Study

    ratn: not reported in source

    cerebral cortex
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Increases did occur in the basal and hypoxia-evoked levels of hypoxanthine, xanthine and, especially, of uric acid.
    2 context sentences
    Summary · context
    The effects of the purine precursor 5-aminoimidazole-4-carboxamide riboside (AICAriboside) on the release of purines from cerebral cortices of normoxic and hypoxic/hypotensive rats was studied with the cortical cup technique.
    Summary · context
    AICAriboside was administered either intravascularly (50 mg/kg) or intraperitoneally (500 mg/kg) to ascertain whether this agent can be used to enhance adenosine levels in the cerebral cortical interstitial fluid.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats, AICAriboside increased basal and hypoxia-evoked cortical uric acid levels.

    In plain wordsIn rats, AICAriboside increased cortical uric acid levels under basal and low oxygen conditions.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseUric acid levels
    Study

    ratn: not reported in source

    cerebral cortex
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Increases did occur in the basal and hypoxia-evoked levels of hypoxanthine, xanthine and, especially, of uric acid.
    2 context sentences
    Summary · context
    The effects of the purine precursor 5-aminoimidazole-4-carboxamide riboside (AICAriboside) on the release of purines from cerebral cortices of normoxic and hypoxic/hypotensive rats was studied with the cortical cup technique.
    Summary · context
    AICAriboside was administered either intravascularly (50 mg/kg) or intraperitoneally (500 mg/kg) to ascertain whether this agent can be used to enhance adenosine levels in the cerebral cortical interstitial fluid.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.