Study · Ex vivo tissue · rat · 2002
18 resultsChen HC, Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert M, Farese RV Jr, Farese RV
The Journal of biological chemistry26 Apr 2002Cited by 153 (Europe PMC)
10 results from studies that gave the peptide. No result from this study comes from people.
In rat EDL muscle, AICAR activated PYK2.
In plain wordsIn lab tests, AICAR activated PYK2 in rat muscle.
ratn: not reported in source
extensor digitorum longus muscleSource sentences
In rat extensor digitorum longus (EDL) muscles, (a) AMPK activator, 5-aminoimidazole-4-carboxamide-1-beta-d-riboside (AICAR), activated PYK2, ERK and aPKCs;
In rat EDL muscle, AICAR activated ERK.
In plain wordsIn lab tests, AICAR activated ERK in rat muscle.
ratn: not reported in source
extensor digitorum longus muscleSource sentences
In rat extensor digitorum longus (EDL) muscles, (a) AMPK activator, 5-aminoimidazole-4-carboxamide-1-beta-d-riboside (AICAR), activated PYK2, ERK and aPKCs;
In rat EDL muscle, AICAR activated atypical protein kinase Cs.
In plain wordsIn lab tests, AICAR activated atypical protein kinase Cs in rat muscle.
ratn: not reported in source
extensor digitorum longus muscleSource sentences
In rat extensor digitorum longus (EDL) muscles, (a) AMPK activator, 5-aminoimidazole-4-carboxamide-1-beta-d-riboside (AICAR), activated PYK2, ERK and aPKCs;
In laboratory muscle models, AICAR and dinitrophenol had similar effects on ERK.
In plain wordsIn lab tests, AICAR and dinitrophenol had similar effects on ERK.
n: not reported in source
Source sentences
AMPK activator dinitrophenol had effects on ERK, aPKCs, and 2-DOG uptake similar to those of AICAR.
In laboratory muscle models, AICAR and dinitrophenol had similar effects on atypical protein kinase Cs.
In plain wordsIn lab tests, AICAR and dinitrophenol had similar effects on atypical protein kinase Cs.
n: not reported in source
Source sentences
AMPK activator dinitrophenol had effects on ERK, aPKCs, and 2-DOG uptake similar to those of AICAR.
In laboratory muscle models, AICAR and dinitrophenol had similar effects on 2-DOG uptake.
In plain wordsIn lab tests, AICAR and dinitrophenol had similar effects on sugar uptake.
n: not reported in source
Source sentences
AMPK activator dinitrophenol had effects on ERK, aPKCs, and 2-DOG uptake similar to those of AICAR.
In L6 myotubes, AICAR activated PYK2.
In plain wordsIn cells, AICAR activated PYK2.
n: not reported in source
L6 myotubesSource sentences
Similarly, in L6 myotubes, (a) AICAR activated PYK2, ERK, PLD, and aPKCs;
In L6 myotubes, AICAR activated ERK.
In plain wordsIn cells, AICAR activated ERK.
n: not reported in source
L6 myotubesSource sentences
Similarly, in L6 myotubes, (a) AICAR activated PYK2, ERK, PLD, and aPKCs;
In L6 myotubes, AICAR activated PLD.
In plain wordsIn cells, AICAR activated PLD.
n: not reported in source
L6 myotubesSource sentences
Similarly, in L6 myotubes, (a) AICAR activated PYK2, ERK, PLD, and aPKCs;
In L6 myotubes, AICAR activated atypical protein kinase Cs.
In plain wordsIn cells, AICAR activated atypical protein kinase Cs.
n: not reported in source
L6 myotubesSource sentences
Similarly, in L6 myotubes, (a) AICAR activated PYK2, ERK, PLD, and aPKCs;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).
In rat EDL muscle, genistein and PD98059 blocked AICAR-induced ERK activation.
In plain wordsIn lab tests, genistein and PD98059 blocked AICAR-induced ERK activation in rat muscle.
ratn: not reported in source
extensor digitorum longus muscleSource sentences
(b) effects of AICAR on ERK and aPKCs were blocked by tyrosine kinase inhibitor, genistein, and MEK1 inhibitor, PD98059;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
In rat EDL muscle, genistein, PD98059 and 1-butanol inhibited AICAR-induced aPKC activation.
In plain wordsIn lab tests, genistein, PD98059 and 1-butanol inhibited AICAR-induced aPKC activation in rat muscle.
ratn: not reported in source
extensor digitorum longus muscleSource sentences
(b) effects of AICAR on ERK and aPKCs were blocked by tyrosine kinase inhibitor, genistein, and MEK1 inhibitor, PD98059;
and (c) effects of AICAR on aPKCs and 2-deoxyglucose (2-DOG) uptake were inhibited by genistein, PD98059, and PLD-inhibitor, 1-butanol.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
In rat EDL muscle, genistein, PD98059 and 1-butanol inhibited AICAR-induced 2-deoxyglucose uptake.
In plain wordsIn lab tests, these inhibitors reduced AICAR-induced sugar uptake in rat muscle.
ratn: not reported in source
extensor digitorum longus muscleSource sentences
and (c) effects of AICAR on aPKCs and 2-deoxyglucose (2-DOG) uptake were inhibited by genistein, PD98059, and PLD-inhibitor, 1-butanol.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
In L6 myotubes, genistein, PD98059 and dominant-negative PYK2 inhibited AICAR-induced ERK activation.
In plain wordsIn cells, genistein, PD98059 and altered PYK2 inhibited AICAR-induced ERK activation.
n: not reported in source
L6 myotubesSource sentences
(b) effects of AICAR on ERK were inhibited by genistein, PD98059, and expression of dominant-negative PYK2;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
In L6 myotubes, UO126 inhibited AICAR-induced PLD activation.
In plain wordsIn cells, UO126 inhibited AICAR-induced PLD activation.
n: not reported in source
L6 myotubesSource sentences
(c) effects of AICAR on PLD were inhibited by MEK1 inhibitor UO126;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
In L6 myotubes, chemical inhibitors and dominant-negative pathway proteins inhibited AICAR-induced aPKC activation.
In plain wordsIn cells, chemical inhibitors and altered pathway proteins inhibited AICAR-induced aPKC activation.
n: not reported in source
L6 myotubesSource sentences
(d) effects of AICAR on aPKCs were inhibited by genistein, PD98059, 1-butanol, and expression of dominant-negative forms of PYK2, GRB2, SOS, RAS, RAF, and ERK;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
In L6 myotubes, chemical inhibitors and kinase-inactive proteins inhibited AICAR-induced 2DOG uptake.
In plain wordsIn cells, chemical inhibitors and inactive proteins inhibited AICAR-induced sugar uptake.
n: not reported in source
L6 myotubesSource sentences
and (e) effects of AICAR on 2DOG uptake/GLUT4 translocation were inhibited by genistein, PD98059, UO126, 1-butanol, cell-permeable myristoylated PKC-zeta pseudosubstrate, and expression of kinase-inactive RAF, ERK, and PKC-zeta.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
In L6 myotubes, chemical inhibitors and kinase-inactive proteins inhibited AICAR-induced GLUT4 translocation.
In plain wordsIn cells, chemical inhibitors and inactive proteins inhibited AICAR-induced movement of GLUT4.
n: not reported in source
L6 myotubesSource sentences
and (e) effects of AICAR on 2DOG uptake/GLUT4 translocation were inhibited by genistein, PD98059, UO126, 1-butanol, cell-permeable myristoylated PKC-zeta pseudosubstrate, and expression of kinase-inactive RAF, ERK, and PKC-zeta.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
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21 Oct 2026, 15:58 UTC
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21 Oct 2026, 12:50 UTC
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