AICAR (acadesine) studies: 330 papers with results
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- Chronic treatment with the AMP-kinase activator AICAR increases glycogen storage and fatty acid oxidation in skeletal muscles but does not reduce hyperglucagonemia and hyperglycemia in insulin deficient rats.
Vitzel KF · PloS one · 2013
Animal study (in vivo) · rat · 6 results
- Post-treatment with the combination of 5-aminoimidazole-4-carboxyamide ribonucleoside and carnitine improves renal function after ischemia/reperfusion injury.
Idrovo JP · Shock (Augusta, Ga.) · 2012
Animal study (in vivo) · rat · 11 results
- Differential attenuation of AMPK activation during acute exercise following exercise training or AICAR treatment.
McConell GK · Journal of applied physiology (Bethesda, Md. : 1985) · 2008
Animal study (in vivo) · rat · 4 results
- Effects of chronic AICAR administration on the metabolic and contractile phenotypes of rat slow- and fast-twitch skeletal muscles.
Bamford JA · Canadian journal of physiology and pharmacology · 2003
Animal study (in vivo) · rat · 8 results
- SESN2 prevents the slow-to-fast myofiber shift in denervated atrophy via AMPK/PGC-1α pathway.
Yang X · Cellular & molecular biology letters · 2022
Animal study (in vivo) · mouse · 2 results
- Whether AICAR in Pregnancy or Lactation Prevents Hypertension Programmed by High Saturated Fat Diet: A Pilot Study.
Tsai WL · Nutrients · 2020
Animal study (in vivo) · rat · 9 results
- AICAR Prevents Acute Olanzapine-Induced Disturbances in Glucose Homeostasis.
Bush ND · The Journal of pharmacology and experimental therapeutics · 2018
Animal study (in vivo) · mouse · 8 results
- AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids.
King-Himmelreich TS · Neuropharmacology · 2017
Animal study (in vivo) · mouse · 1 result
- Administration of AICAR, an AMPK Activator, Prevents and Reverses Diabetic Polyneuropathy (DPN) by Regulating Mitophagy.
Chandrasekaran K · International journal of molecular sciences · 2024
Animal study (in vivo) · mouse · 8 results
- AICAR Ameliorates Non-Alcoholic Fatty Liver Disease via Modulation of the HGF/NF-κB/SNARK Signaling Pathway and Restores Mitochondrial and Endoplasmic Reticular Impairments in High-Fat Diet-Fed Rats.
Zineldeen DH · International journal of molecular sciences · 2023
Animal study (in vivo) · rat · 6 results
- AMP-activated protein kinase activation ameliorates eicosanoid dysregulation in high-fat-induced kidney disease in mice.
Declèves AE · Journal of lipid research · 2019
Animal study (in vivo) · mouse · 3 results
- Reductions in RIP140 are not required for exercise- and AICAR-mediated increases in skeletal muscle mitochondrial content.
Frier BC · Journal of applied physiology (Bethesda, Md. : 1985) · 2011
Animal study (in vivo) · rat · 6 results
- The Chinese medicine Chai Hu Li Zhong Tang protects against non-alcoholic fatty liver disease by activating AMPKα.
Zhang M · Bioscience reports · 2018
Animal study (in vivo) · rat · 21 results
- Hypothalamic AMPK-induced autophagy ameliorates hypercatabolism in septic rats by regulating POMC expression.
Cao C · Biochemical and biophysical research communications · 2018
Animal study (in vivo) · rat · 3 results
- The AMPK Activator Aicar Ameliorates Age-Dependent Myocardial Injury in Murine Hemorrhagic Shock.
Matsiukevich D · Shock (Augusta, Ga.) · 2017
Animal study (in vivo) · mouse · 3 results
- Aerobic exercise suppresses CCN2 secretion from senescent muscle stem cells and boosts muscle regeneration in aged mice.
Li F · Journal of cachexia, sarcopenia and muscle · 2024
Animal study (in vivo) · mouse · 3 results
- Exogenous H2S alleviates senescence of glomerular mesangial cells through up-regulating mitophagy by activation of AMPK-ULK1-PINK1-parkin pathway in mice.
E Y · Biochimica et biophysica acta. Molecular cell research · 2023
Animal study (in vivo) · mouse · 27 results
- AMPK activation attenuates cancer-induced bone pain by reducing mitochondrial dysfunction-mediated neuroinflammation.
Yang H · Acta biochimica et biophysica Sinica · 2023
Animal study (in vivo) · rat · 5 results
- Activation of AMPKα2 Is Not Required for Mitochondrial FAT/CD36 Accumulation during Exercise.
Monaco C · PloS one · 2015
Animal study (in vivo) · 2 results
- AMPK activation ameliorates fine particulate matter-induced hepatic injury.
Song L · Environmental science and pollution research international · 2020
Animal study (in vivo) · mouse · 2 results
- Exercise Improves Outcomes of Surgery on Fatty Liver in Mice: A Novel Effect Mediated by the AMPK Pathway.
Linecker M · Annals of surgery · 2020
Animal study (in vivo) · mouse · 6 results
- Chronic activation of central AMPK attenuates glucose-stimulated insulin secretion and exacerbates hepatic insulin resistance in diabetic rats.
Park S · Brain research bulletin · 2014
Animal study (in vivo) · rat · 14 results
- Simvastatin attenuates silica-induced pulmonary inflammation and fibrosis in rats via the AMPK-NOX pathway.
Bo C · BMC pulmonary medicine · 2024
Animal study (in vivo) · rat · 2 results
- AICAR attenuates postoperative abdominal adhesion formation by inhibiting oxidative stress and promoting mesothelial cell repair.
Wu Y · PloS one · 2022
Animal study (in vivo) · rat · 14 results
- Estradiol regulates effects of hindbrain activator 5-aminoimidazole-4-carboxamide-riboside administration on hypothalamic adenosine 5'-monophosphate-activated protein kinase activity and metabolic neurotransmitter mRNA and protein expression.
Alenazi FS · Journal of neuroscience research · 2015
Animal study (in vivo) · rat · 15 results
- AICAR Improves Outcomes of Metabolic Syndrome and Type 2 Diabetes Induced by High-Fat Diet in C57Bl/6 Male Mice.
Tukhovskaya EA · International journal of molecular sciences · 2022
Animal study (in vivo) · mouse · 6 results
- Central infusion of leptin does not increase AMPK signaling in skeletal muscle of sheep.
Laker RC · American journal of physiology. Regulatory, integrative and comparative physiology · 2011
Animal study (in vivo) · sheep · 1 result
- AMP-activated protein kinase activation prevents denervation-induced decline in gastrocnemius GLUT-4.
Paulsen SR · Journal of applied physiology (Bethesda, Md. : 1985) · 2001
Animal study (in vivo) · rat · 6 results
- Gypensapogenin I alleviates PANoptosis, ferroptosis, and oxidative stress in myocardial ischemic-reperfusion injury by targeting the NOX2/AMPK pathway.
Chen Y · Frontiers in cell and developmental biology · 2025
Animal study (in vivo) · mouse · 5 results
- 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside-attenuates LPS/D-Gal-induced acute hepatitis in mice.
Zhou D · Innate immunity · 2015
Animal study (in vivo) · mouse · 11 results
- Central administration of AICAR attenuates hypertension via AMPK/Nrf2 pathway in the hypothalamic paraventricular nucleus of hypertensive rats.
Fu LY · European journal of pharmacology · 2024
Animal study (in vivo) · rat · 11 results
- AMPK upregulates KCa2.3 channels and ameliorates endothelial dysfunction in diet-induced obese mice.
Pang ZD · Biochemical pharmacology · 2021
Animal study (in vivo) · mouse · 4 results
- Activation of AMPK alleviates cardiopulmonary bypass-induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder.
Wang Z · Cardiovascular therapeutics · 2018
Animal study (in vivo) · rat · 9 results
- The AMPK allosteric activator MK-8722 improves the histology and spliceopathy in myotonic dystrophy type 1 (DM1) skeletal muscle.
Ravel-Chapuis A · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
Animal study (in vivo) · mouse · 5 results
- Akebia saponin D attenuates allergic airway inflammation through AMPK activation.
Xuan L · Journal of natural medicines · 2024
Animal study (in vivo) · mouse · 14 results
- Mitochondrial dysfunction in skeletal muscle of fukutin-deficient mice is resistant to exercise- and 5-aminoimidazole-4-carboxamide ribonucleotide-induced rescue.
Southern WM · Experimental physiology · 2020
Animal study (in vivo) · mouse · 2 results
- AICAR attenuates ischemia-reperfusion-induced AKI by modulating AMPK-TXNIP-NLRP3 pathway and energy metabolism.
Gan L · Cellular and molecular life sciences : CMLS · 2026
Animal study (in vivo) · rat · 20 results
- A comparison of chronic AICAR treatment-induced metabolic adaptations in red and white muscles of rats.
Suwa M · The journal of physiological sciences : JPS · 2015
Animal study (in vivo) · rat · 4 results
- Chronic treatment of old mice with AICAR reverses age-related changes in exercise performance and skeletal muscle gene expression.
Wilcox SH · FASEB bioAdvances · 2025
Animal study (in vivo) · mouse · 12 results
- AMPK activation improves depression-like symptoms in olfactory bulbectomized mice by regulating microglia M1/M2 polarization in the hippocampus.
Odaira-Satoh T · Brain, behavior, & immunity - health · 2025
Animal study (in vivo) · mouse · 6 results
- AMPK agonist AICAR ameliorates maternal hepatic lipid metabolism disorder, inflammation, and fibrosis caused by PM2.5 exposure during pregnancy.
Wan T · Scientific reports · 2025
Animal study (in vivo) · mouse · 3 results
- Exercise-induced Sesn2 mediates autophagic flux to alleviate neural damage after ischemic stroke in mice.
Zhao Y · Experimental neurology · 2025
Animal study (in vivo) · mouse · 4 results
- Activation AMPK in Hypothalamic Paraventricular Nucleus Improves Renovascular Hypertension Through ERK1/2-NF-κB Pathway.
Fu LY · Cardiovascular toxicology · 2024
Animal study (in vivo) · rat · 8 results
- Chronic 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Treatment Induces Phenotypic Changes in Skeletal Muscle, but Does Not Improve Disease Outcomes in the R6/2 Mouse Model of Huntington's Disease.
Paré MF · Frontiers in neurology · 2017
Animal study (in vivo) · mouse · 6 results
- Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism.
Baggott JE · European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2007
Animal study (in vivo) · rat · 1 result
- Brain AMPK signaling improves intestinal barrier function through brain orexin and the vagal pathway in rats.
Funayama T · Neuroscience letters · 2025
Animal study (in vivo) · rat · 10 results
- AMPK phosphorylation of KCa2.3 alleviates angiotensin II-induced endothelial dysfunction.
Pang ZD · Biochemical pharmacology · 2025
Animal study (in vivo) · mouse · 3 results
- 5-Aminoimidazole-4-carboxamide ribonucleotide prevents fat gain following the cessation of voluntary physical activity.
Ruegsegger GN · Experimental physiology · 2017
Animal study (in vivo) · rat · 8 results
- Loss of the anorexic response to systemic 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside administration despite reducing hypothalamic AMP-activated protein kinase phosphorylation in insulin-deficient rats.
Vitzel KF · PloS one · 2013
Animal study (in vivo) · rat · 13 results
- AMP-Activated Protein Kinase Treatment Ameliorates Chronic Restraint Stress Induced Memory Impairment in Early Adolescent Rat by Restoring Metabolite Profile and Synaptic Proteins.
Rajan KE · Neurochemical research · 2024
Animal study (in vivo) · rat · 2 results