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Study · Ex vivo tissue · mouse · 2007

2 results

Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise.

Klein DK, Pilegaard H, Treebak JT, Jensen TE, Viollet B, Schjerling P, Wojtaszewski JF

American journal of physiology. Endocrinology and metabolism21 Aug 2007Cited by 34 (Europe PMC)

PMID17711995 (opens in a new tab)DOI10.1152/ajpendo.00382.2007 (opens in a new tab)PepBankPUB-17711995
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In isolated wild-type mouse EDL muscle, AICAR did not change PDH-E1alpha phosphorylation.

    In plain wordsIn lab tests of mouse muscle, AICAR did not change PDH-E1alpha phosphorylation in the normal genotype.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changePDH-E1alpha phosphorylation in WT
    Study

    mousen: not reported in source

    Isolated resting EDL muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In isolated resting EDL muscles, activation of AMPK signaling by AICAR did not change PDH-E(1)alpha phosphorylation in either genotype.
  2. 02LabEx vivo tissueMechanism

    In isolated AMPKalpha2-knockout mouse EDL muscle, AICAR did not change PDH-E1alpha phosphorylation.

    In plain wordsIn lab tests of mouse muscle without AMPKalpha2, AICAR did not change PDH-E1alpha phosphorylation.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changePDH-E1alpha phosphorylation in AMPKalpha2 knockout
    Study

    mousen: not reported in source

    Isolated resting EDL muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In isolated resting EDL muscles, activation of AMPK signaling by AICAR did not change PDH-E(1)alpha phosphorylation in either genotype.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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