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Study · In vitro (cells) · 2017

2 results

4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells.

Duan P, Hu C, Quan C, Yu T, Huang W, Chen W, Tang S, Shi Y, Martin FL, Yang K

Toxicology letters29 Dec 2016Cited by 61 (Europe PMC)

PMID28041982 (opens in a new tab)DOI10.1016/j.toxlet.2016.12.015 (opens in a new tab)PepBankPUB-28041982
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In nonylphenol-treated Sertoli cells, AICAR strengthened induced autophagy.

    In plain wordsIn cells, AICAR increased autophagy compared with nonylphenol alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAutophagy
    Study

    n: not reported in source

    Nonylphenol-treated Sertoli cells
    Comparator
    Nonylphenol without AICAR
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    1mMAs given in this study.

    Source sentences

    Summary
    Co-treatment with 1mM AICAR remarkably strengthened NP-induced autophagy and mTOR inhibition in SCs.
  2. 02LabIn vitro (cells)Mechanism

    In nonylphenol-treated Sertoli cells, AICAR strengthened mTOR inhibition.

    In plain wordsIn cells, AICAR increased mTOR inhibition compared with nonylphenol alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasemTOR inhibition
    Study

    n: not reported in source

    Nonylphenol-treated Sertoli cells
    Comparator
    Nonylphenol without AICAR
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    1mMAs given in this study.

    Source sentences

    Summary
    Co-treatment with 1mM AICAR remarkably strengthened NP-induced autophagy and mTOR inhibition in SCs.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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