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Study · Ex vivo tissue · rat · 2018

6 results

Prior treatment with the AMPK activator AICAR induces subsequently enhanced glucose uptake in isolated skeletal muscles from 24-month-old rats.

Oki K, Arias EB, Kanzaki M, Cartee GD

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme8 Mar 2018Cited by 13 (Europe PMC)

PMID29518344 (opens in a new tab)PMCIDPMC6066428 (opens in a new tab)DOI10.1139/apnm-2017-0858 (opens in a new tab)PepBankPUB-29518344
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In isolated muscles from old rats, prior AICAR treatment increased insulin-stimulated glucose uptake.

    In plain wordsIn lab tests with old rat muscles, prior AICAR increased insulin-stimulated glucose uptake.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseInsulin-stimulated glucose uptake
    Study

    ratn: not reported in source

    Isolated epitrochlearis muscles from 24-month-old male rats
    Comparator
    No prior AICAR
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 60 minAs given in this study (rat).

    Source sentences

    Summary
    Prior ex vivo AICAR treatment resulted in greater GU by insulin-stimulated muscles from 24-month-old rats.
    1 context sentence
    Summary · context
    Epitrochlearis muscles from 24-month-old male rats were isolated and initially incubated ±AICAR (60 min), followed by incubation without AICAR (3 h), then incubation ±insulin (50 min).
  2. 02LabEx vivo tissueMechanism

    In isolated muscles from old rats, prior AICAR increased AMPK T172 phosphorylation.

    In plain wordsIn lab tests with old rat muscles, prior AICAR increased AMPK T172 phosphorylation.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAMPK T172 phosphorylation
    Study

    ratn: not reported in source

    Isolated epitrochlearis muscles from 24-month-old male rats
    Comparator
    No prior AICAR
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · 60 minAs given in this study (rat).

    Source sentences

    Summary
    Prior AICAR treatment also resulted in greater phosphorylation of AMPK (T172) and AS160 (S588, T642, and S704).
    1 context sentence
    Summary · context
    Epitrochlearis muscles from 24-month-old male rats were isolated and initially incubated ±AICAR (60 min), followed by incubation without AICAR (3 h), then incubation ±insulin (50 min).
  3. 03LabEx vivo tissueMechanism

    In isolated muscles from old rats, prior AICAR increased AS160 S588 phosphorylation.

    In plain wordsIn lab tests with old rat muscles, prior AICAR increased AS160 S588 phosphorylation.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAS160 S588 phosphorylation
    Study

    ratn: not reported in source

    Isolated epitrochlearis muscles from 24-month-old male rats
    Comparator
    No prior AICAR
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · 60 minAs given in this study (rat).

    Source sentences

    Summary
    Prior AICAR treatment also resulted in greater phosphorylation of AMPK (T172) and AS160 (S588, T642, and S704).
    1 context sentence
    Summary · context
    Epitrochlearis muscles from 24-month-old male rats were isolated and initially incubated ±AICAR (60 min), followed by incubation without AICAR (3 h), then incubation ±insulin (50 min).
  4. 04LabEx vivo tissueMechanism

    In isolated muscles from old rats, prior AICAR increased AS160 T642 phosphorylation.

    In plain wordsIn lab tests with old rat muscles, prior AICAR increased AS160 T642 phosphorylation.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAS160 T642 phosphorylation
    Study

    ratn: not reported in source

    Isolated epitrochlearis muscles from 24-month-old male rats
    Comparator
    No prior AICAR
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · 60 minAs given in this study (rat).

    Source sentences

    Summary
    Prior AICAR treatment also resulted in greater phosphorylation of AMPK (T172) and AS160 (S588, T642, and S704).
    1 context sentence
    Summary · context
    Epitrochlearis muscles from 24-month-old male rats were isolated and initially incubated ±AICAR (60 min), followed by incubation without AICAR (3 h), then incubation ±insulin (50 min).
  5. 05LabEx vivo tissueMechanism

    In isolated muscles from old rats, prior AICAR increased AS160 S704 phosphorylation.

    In plain wordsIn lab tests with old rat muscles, prior AICAR increased AS160 S704 phosphorylation.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAS160 S704 phosphorylation
    Study

    ratn: not reported in source

    Isolated epitrochlearis muscles from 24-month-old male rats
    Comparator
    No prior AICAR
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · 60 minAs given in this study (rat).

    Source sentences

    Summary
    Prior AICAR treatment also resulted in greater phosphorylation of AMPK (T172) and AS160 (S588, T642, and S704).
    1 context sentence
    Summary · context
    Epitrochlearis muscles from 24-month-old male rats were isolated and initially incubated ±AICAR (60 min), followed by incubation without AICAR (3 h), then incubation ±insulin (50 min).
  6. 06LabEx vivo tissueMechanism

    In isolated muscles from old rats, prior AICAR did not alter GLUT4 protein abundance.

    In plain wordsIn lab tests with old rat muscles, prior AICAR did not change GLUT4 protein abundance.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeGLUT4 abundance
    Study

    ratn: not reported in source

    Isolated epitrochlearis muscles from 24-month-old male rats
    Comparator
    No prior AICAR
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · 60 minAs given in this study (rat).

    Source sentences

    Summary
    Glucose transporter type 4 (GLUT4) protein abundance was unaffected by prior AICAR and/or insulin treatment.
    1 context sentence
    Summary · context
    Epitrochlearis muscles from 24-month-old male rats were isolated and initially incubated ±AICAR (60 min), followed by incubation without AICAR (3 h), then incubation ±insulin (50 min).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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