In primary human myotubes, AICAR activation of AMPK increased NAMPT mRNA approximately 3.4-fold (P < 0.05).
In plain wordsIn cells, AICAR increased NAMPT gene expression.
- Peptide
- AICAR (acadesine)
- Outcome
- IncreaseNAMPT mRNA
- Study
humann: not reported in source
Primary human myotubes- Outcome group
- Receptor activity and mechanism · Musculoskeletal
- Studied dose
- Dose not stated
Measurements
- NAMPT mRNA
- ≈ 3.4 fold
- AMPK activation via AICAR
Source sentences
Activation of AMPK via AICAR resulted in an approximately 3.4-fold increase in NAMPT mRNA (P < 0.05) as well as modest increases in NAMPT protein (P < 0.05) and mitochondrial content (P < 0.05).
1 context sentence(design, population, supporting numbers)
Treatment of primary human myotubes with forskolin, a cAMP signaling pathway activator, resulted in an approximately 2.5-fold increase in NAMPT protein expression, whereas treatment with ionomycin had no effect.