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Study · Ex vivo tissue · rat · 2002

1 result

Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle.

Terada S, Goto M, Kato M, Kawanaka K, Shimokawa T, Tabata I

Biochemical and biophysical research communications1 Aug 2002Cited by 247 (Europe PMC)

PMID12163024 (opens in a new tab)DOI10.1016/s0006-291x(02)00881-1 (opens in a new tab)PepBankPUB-12163024
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In isolated rat muscle, AICAR elevated PGC-1 mRNA approximately threefold versus control muscle.

    In plain wordsIn lab tests, AICAR increased PGC-1 gene expression in rat muscle compared with control muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePGC-1 mRNA expression
    Study

    ratn = 6

    epitrochlearis muscle
    Comparator
    Control muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    0.5mM · 18-hAs given in this study (rat).

    Measurements

    PGC-1 mRNA
    ≈ 3 fold
    versus control muscle

    Source sentences

    Summary
    Finally, PGC-1 mRNA expression in the muscle incubated for 18-h with 0.5mM 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR: a 5' AMP-activated protein kinase (AMPK) activator) was elevated to approximately 3-fold of the control muscle (n=6, p<0.001).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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