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Study · Ex vivo tissue · mouse · 2011

3 results

AICAR reverses ketone body mediated insulin resistance in isolated oxidative muscle.

Ivarsson N, Zhang SJ, Katz A

Biochemical and biophysical research communications1 Oct 2011Cited by 8 (Europe PMC)

PMID21982775 (opens in a new tab)DOI10.1016/j.bbrc.2011.09.122 (opens in a new tab)PepBankPUB-21982775
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In isolated mouse soleus muscle exposed to BOH, AICAR restored insulin-mediated glucose uptake to approximately 80% of the normal response.

    In plain wordsIn lab tests on mouse muscle, AICAR restored glucose uptake under BOH exposure toward the normal insulin response.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseInsulin-mediated glucose uptake
    Study

    mousen: not reported in source

    Isolated soleus muscle exposed to β-hydroxybutyrate
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    2mM · 2hAs given in this study (mouse).

    Measurements

    Insulin response
    ≈ 80%
    Normal insulin effect on 2-DG uptake

    Source sentences

    Summary
    Addition of 2mM AICAR during the last 2h of prolonged incubation increased the insulin response in the presence of BOH to ∼80% of the normal insulin effect on 2-DG uptake.
    1 context sentence
    Summary · context
    Isolated mouse soleus muscle was incubated in vitro in the absence or presence of 5mM BOH for ∼20 h.
  2. 02LabEx vivo tissueMechanism

    In isolated mouse soleus muscle, AICAR did not restore the insulin effect on Akt phosphorylation during BOH exposure.

    In plain wordsIn lab tests on mouse muscle, AICAR did not restore insulin-induced Akt phosphorylation during BOH exposure.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeAkt phosphorylation
    Study

    mousen: not reported in source

    Isolated soleus muscle exposed to β-hydroxybutyrate
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    2mM · 2hAs given in this study (mouse).

    Source sentences

    Summary
    The AICAR-mediated reversal of the insulin resistance was not associated with a restoration of the insulin effect on Akt/protein kinase B phosphorylation.
    1 context sentence
    Summary · context
    Isolated mouse soleus muscle was incubated in vitro in the absence or presence of 5mM BOH for ∼20 h.
  3. 03LabEx vivo tissueMechanism

    In isolated mouse soleus muscle, AICAR enhanced insulin-induced AS160 phosphorylation.

    In plain wordsIn lab tests on mouse muscle, AICAR increased AS160 phosphorylation induced by insulin.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAS160 phosphorylation
    Study

    mousen: not reported in source

    Isolated soleus muscle exposed to β-hydroxybutyrate
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    2mM · 2hAs given in this study (mouse).

    Source sentences

    Summary
    However, AICAR enhanced the insulin-induced phosphorylation of the Akt substrate, AS160.
    1 context sentence
    Summary · context
    Isolated mouse soleus muscle was incubated in vitro in the absence or presence of 5mM BOH for ∼20 h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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