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Study · In vitro (cells) · mouse · 2013

1 result

Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism.

Salvadó L, Coll T, Gómez-Foix AM, Salmerón E, Barroso E, Palomer X, Vázquez-Carrera M

Diabetologia5 Mar 2013Cited by 175 (Europe PMC)

PMID23460021 (opens in a new tab)DOI10.1007/s00125-013-2867-3 (opens in a new tab)PepBankPUB-23460021
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In skeletal muscle cells, AICAR prevented palmitate-induced ER stress marker induction.

    In plain wordsIn cells, AICAR prevented palmitate-induced increases in ER stress markers.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseER stress markers
    Study

    mouse and humann: not reported in source

    Mouse C2C12 myotubes and human LHCN-M2 cells
    Comparator
    Palmitate-exposed cells
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The induction of ER stress markers by palmitate was prevented by the presence of the AMPK activators AICAR and A-769662.
    1 context sentence
    Summary · context
    Studies were conducted in mouse C2C12 myotubes and in the human myogenic cell line LHCN-M2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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