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Study · In vitro (cells) · rat · 2018

1 result

Berberine attenuates apoptosis in rat retinal Müller cells stimulated with high glucose via enhancing autophagy and the AMPK/mTOR signaling.

Chen H, Ji Y, Yan X, Su G, Chen L, Xiao J

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2 Oct 2018Cited by 82 (Europe PMC)

PMID30372821 (opens in a new tab)DOI10.1016/j.biopha.2018.09.140 (opens in a new tab)PepBankPUB-30372821
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In high-glucose Müller cells, AICAR strengthened the effect of berberine.

    In plain wordsIn cells exposed to high glucose, AICAR strengthened berberine's effect compared with berberine alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseModification of berberine effect
    Study

    ratn: not reported in source

    High-glucose retinal Müller cells
    Comparator
    Berberine without AICAR
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The effect of BBR was partly blocked by compound C and strengthened by AICAR.
    2 context sentences
    Summary · context
    The present study investigated the effect of BBR on Müller cells stimulated with high glucose (HG).
    Summary · context
    Primary retinal Müller cells were incubated with high glucose to induce cell apoptosis

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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