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Study · In vitro (cells) · rat · 2019

4 results

AICAR, an AMPK activator, protects against cisplatin-induced acute kidney injury through the JAK/STAT/SOCS pathway.

Tsogbadrakh B, Ryu H, Ju KD, Lee J, Yun S, Yu KS, Kim HJ, Ahn C, Oh KH

Biochemical and biophysical research communications4 Jan 2019Cited by 61 (Europe PMC)

PMID30616891 (opens in a new tab)DOI10.1016/j.bbrc.2018.12.159 (opens in a new tab)PepBankPUB-30616891
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In NRK-52E cells, AICAR protected against cisplatin-induced acute tubular injury.

    In plain wordsIn rat kidney cells, AICAR reduced injury from cisplatin compared with cisplatin treatment.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseAcute tubular injury
    Study

    ratn: not reported in source

    Cisplatin-treated NRK-52E cells
    Comparator
    Cisplatin treatment
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR was protective against cisplatin-induced acute tubular injury by up-regulating p-AMPK expression in NRK-52E cells.
    1 context sentence
    Summary · context
    For in vitro studies, NRK-52E normal rat kidney cells were treated with cisplatin and/or AICAR.
  2. 02LabIn vitro (cells)Mechanism

    In cisplatin-treated NRK-52E cells, AICAR increased p-AMPK expression.

    In plain wordsIn rat kidney cells exposed to cisplatin, AICAR increased p-AMPK compared with cisplatin treatment.

    Peptide
    AICAR (acadesine)
    Outcome
    Increasep-AMPK expression
    Study

    ratn: not reported in source

    Cisplatin-treated NRK-52E cells
    Comparator
    Cisplatin treatment
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR was protective against cisplatin-induced acute tubular injury by up-regulating p-AMPK expression in NRK-52E cells.
    1 context sentence
    Summary · context
    For in vitro studies, NRK-52E normal rat kidney cells were treated with cisplatin and/or AICAR.
  3. 03LabIn vitro (cells)Mechanism

    In cisplatin-treated NRK-52E cells, AICAR ameliorated JAK2 protein expression, with no stated direction in the result sentence.

    In plain wordsIn cells from rat kidneys, AICAR changed the reported JAK2 response to cisplatin, with no stated direction.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedJAK2 protein expression
    Study

    ratn: not reported in source

    Cisplatin-treated NRK-52E cells
    Comparator
    Cisplatin treatment
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Protein expression levels of JAK2/STAT1 were markedly ameliorated in NRK-52E cells by AICAR.
    1 context sentence
    Summary · context
    For in vitro studies, NRK-52E normal rat kidney cells were treated with cisplatin and/or AICAR.
  4. 04LabIn vitro (cells)Mechanism

    In cisplatin-treated NRK-52E cells, AICAR ameliorated STAT1 protein expression, with no stated direction in the result sentence.

    In plain wordsIn cells from rat kidneys, AICAR changed the reported STAT1 response to cisplatin, with no stated direction.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedSTAT1 protein expression
    Study

    ratn: not reported in source

    Cisplatin-treated NRK-52E cells
    Comparator
    Cisplatin treatment
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Protein expression levels of JAK2/STAT1 were markedly ameliorated in NRK-52E cells by AICAR.
    1 context sentence
    Summary · context
    For in vitro studies, NRK-52E normal rat kidney cells were treated with cisplatin and/or AICAR.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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