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Study · Other design · mouse · 2019

1 result

Metformin prevents the pathological browning of subcutaneous white adipose tissue.

Auger C, Knuth CM, Abdullahi A, Samadi O, Parousis A, Jeschke MG

Molecular metabolism20 Aug 2019Cited by 48 (Europe PMC)

PMID31668383 (opens in a new tab)PMCIDPMC6728757 (opens in a new tab)DOI10.1016/j.molmet.2019.08.011 (opens in a new tab)PepBankPUB-31668383
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Summary

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Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalOther designMechanism

    In the murine burn and human adipose explant study, AICAR sustained white adipose browning.

    In plain wordsIn a mouse and human tissue study, AICAR sustained the browning of white fat.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedWhite adipose browning
    Study

    mouse and humann: not reported in source

    Murine burn model and human ex vivo adipose explants
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and that AICAR sustains the browning of white adipose
    1 context sentence
    Summary · context
    We used both a murine burn model and human ex vivo adipose explants to assess metformin and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR)'s effects on the development of subcutaneous beige adipose.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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