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Study · Animal study (in vivo) · mouse · 2026

3 results

Electroacupuncture alleviates inflammatory pain through AMPK-autophagy signaling and suppression of iNOS and IL-1β in inflamed tissues.

Xiang H, Li M, Jing X, Hu L, Lan Y, Li H, Tao W, Zou Y, Liu Y, Hu X, Zhang H, Hui-Lin P and 5 more

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Liu W, Liu C, Yang N, Jing-Wen Y, Li J

Molecular pain1 Jan 2026

PMID42808530 (opens in a new tab)DOI10.1177/17448069261491137 (opens in a new tab)PepBankPUB-42808530
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with CFA-induced inflammatory pain, AICAR alone produced analgesia.

    In plain wordsIn mice with inflammatory pain, AICAR alone reduced pain.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseAnalgesia
    Study

    mousen: not reported in source

    CFA-induced inflammatory pain
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mirroring these effects, AICAR alone produced analgesia, increased autophagy, and lowered cytokine expression.
    1 context sentence
    Summary · context
    In a mouse model of complete Freund's adjuvant (CFA)-induced inflammatory pain, we assessed pain behavior and inflammatory markers following EA.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice with CFA-induced inflammatory pain, AICAR alone increased autophagy.

    In plain wordsIn mice with inflammatory pain, AICAR alone increased autophagy.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAutophagy
    Study

    mousen: not reported in source

    CFA-induced inflammatory pain
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mirroring these effects, AICAR alone produced analgesia, increased autophagy, and lowered cytokine expression.
    1 context sentence
    Summary · context
    In a mouse model of complete Freund's adjuvant (CFA)-induced inflammatory pain, we assessed pain behavior and inflammatory markers following EA.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with CFA-induced inflammatory pain, AICAR alone lowered cytokine expression.

    In plain wordsIn mice with inflammatory pain, AICAR alone reduced cytokine expression.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCytokine expression
    Study

    mousen: not reported in source

    CFA-induced inflammatory pain
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mirroring these effects, AICAR alone produced analgesia, increased autophagy, and lowered cytokine expression.
    1 context sentence
    Summary · context
    In a mouse model of complete Freund's adjuvant (CFA)-induced inflammatory pain, we assessed pain behavior and inflammatory markers following EA.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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