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Study · Animal study (in vivo) · rat · 2026

11 results

Ketamine ameliorates postpartum depression-like behaviors in rats exposed to sevoflurane during pregnancy through the AMPK/SIRT1/NLRP3 pathway.

Xue H, Yang X, Kuai S, Zhang Y, Jia Y, Wu Z, Zhao P

Journal of affective disorders14 Feb 2026

PMID41698615 (opens in a new tab)DOI10.1016/j.jad.2026.121439 (opens in a new tab)PepBankPUB-41698615
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In sevoflurane-exposed postpartum rats, AICAR alleviated increased forced swim immobility.

    In plain wordsIn postpartum rats exposed to sevoflurane, AICAR reduced excess immobility compared with exposure without rescue treatment.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseForced swim immobility
    Study

    ratn: not reported in source

    Postpartum rats exposed to sevoflurane during pregnancy
    Comparator
    Sevoflurane exposure without rescue treatment
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with AICAR, MCC950, minocycline, or ketamine alleviated these effects, while dorsomorphin reversed the antidepressant effects of ketamine.
    2 context sentences
    Summary · context
    Sevoflurane-exposed rats exhibited behavioral impairments on postpartum day 1, including increased immobility in the forced swim test, prolonged feeding latency, reduced food consumption in the novelty-suppressed feeding test, and decreased movement in the open field test.
    Summary · context
    To explore the role of the AMPK/SIRT1/NLRP3 pathway and neuroinflammation in postpartum maternal depression, rats were treated with AICAR (an AMPK agonist), MCC950 (an NLRP3 antagonist), and minocycline (a microglial activation inhibitor).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In sevoflurane-exposed postpartum rats, AICAR alleviated prolonged feeding latency.

    In plain wordsIn postpartum rats exposed to sevoflurane, AICAR reduced feeding delay compared with exposure without rescue treatment.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNovelty-suppressed feeding latency
    Study

    ratn: not reported in source

    Postpartum rats exposed to sevoflurane during pregnancy
    Comparator
    Sevoflurane exposure without rescue treatment
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with AICAR, MCC950, minocycline, or ketamine alleviated these effects, while dorsomorphin reversed the antidepressant effects of ketamine.
    2 context sentences
    Summary · context
    Sevoflurane-exposed rats exhibited behavioral impairments on postpartum day 1, including increased immobility in the forced swim test, prolonged feeding latency, reduced food consumption in the novelty-suppressed feeding test, and decreased movement in the open field test.
    Summary · context
    To explore the role of the AMPK/SIRT1/NLRP3 pathway and neuroinflammation in postpartum maternal depression, rats were treated with AICAR (an AMPK agonist), MCC950 (an NLRP3 antagonist), and minocycline (a microglial activation inhibitor).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In sevoflurane-exposed postpartum rats, AICAR alleviated reduced food consumption in the novelty-suppressed feeding test.

    In plain wordsIn postpartum rats exposed to sevoflurane, AICAR improved food consumption compared with exposure without rescue treatment.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseFood consumption
    Study

    ratn: not reported in source

    Postpartum rats exposed to sevoflurane during pregnancy
    Comparator
    Sevoflurane exposure without rescue treatment
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with AICAR, MCC950, minocycline, or ketamine alleviated these effects, while dorsomorphin reversed the antidepressant effects of ketamine.
    2 context sentences
    Summary · context
    Sevoflurane-exposed rats exhibited behavioral impairments on postpartum day 1, including increased immobility in the forced swim test, prolonged feeding latency, reduced food consumption in the novelty-suppressed feeding test, and decreased movement in the open field test.
    Summary · context
    To explore the role of the AMPK/SIRT1/NLRP3 pathway and neuroinflammation in postpartum maternal depression, rats were treated with AICAR (an AMPK agonist), MCC950 (an NLRP3 antagonist), and minocycline (a microglial activation inhibitor).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In sevoflurane-exposed postpartum rats, AICAR alleviated decreased open field movement.

    In plain wordsIn postpartum rats exposed to sevoflurane, AICAR improved movement compared with exposure without rescue treatment.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseOpen field movement
    Study

    ratn: not reported in source

    Postpartum rats exposed to sevoflurane during pregnancy
    Comparator
    Sevoflurane exposure without rescue treatment
    Outcome group
    Exercise and physical function · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with AICAR, MCC950, minocycline, or ketamine alleviated these effects, while dorsomorphin reversed the antidepressant effects of ketamine.
    2 context sentences
    Summary · context
    Sevoflurane-exposed rats exhibited behavioral impairments on postpartum day 1, including increased immobility in the forced swim test, prolonged feeding latency, reduced food consumption in the novelty-suppressed feeding test, and decreased movement in the open field test.
    Summary · context
    To explore the role of the AMPK/SIRT1/NLRP3 pathway and neuroinflammation in postpartum maternal depression, rats were treated with AICAR (an AMPK agonist), MCC950 (an NLRP3 antagonist), and minocycline (a microglial activation inhibitor).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In sevoflurane-exposed postpartum rats, AICAR alleviated decreased hippocampal AMPK expression.

    In plain wordsIn postpartum rats exposed to sevoflurane, AICAR restored AMPK expression compared with exposure without rescue treatment.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAMPK expression
    Study

    ratn: not reported in source

    Postpartum rats exposed to sevoflurane during pregnancy
    Comparator
    Sevoflurane exposure without rescue treatment
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with AICAR, MCC950, minocycline, or ketamine alleviated these effects, while dorsomorphin reversed the antidepressant effects of ketamine.
    2 context sentences
    Summary · context
    These behaviors were accompanied by decreased AMPK/SIRT1 expression, NLRP3 inflammasome activation, and microglial activation in the hippocampus, resulting in significant inflammatory cytokine release.
    Summary · context
    To explore the role of the AMPK/SIRT1/NLRP3 pathway and neuroinflammation in postpartum maternal depression, rats were treated with AICAR (an AMPK agonist), MCC950 (an NLRP3 antagonist), and minocycline (a microglial activation inhibitor).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In sevoflurane-exposed postpartum rats, AICAR alleviated hippocampal NLRP3 inflammasome activation.

    In plain wordsIn postpartum rats exposed to sevoflurane, AICAR reduced NLRP3 activation compared with exposure without rescue treatment.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNLRP3 inflammasome activation
    Study

    ratn: not reported in source

    Postpartum rats exposed to sevoflurane during pregnancy
    Comparator
    Sevoflurane exposure without rescue treatment
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with AICAR, MCC950, minocycline, or ketamine alleviated these effects, while dorsomorphin reversed the antidepressant effects of ketamine.
    2 context sentences
    Summary · context
    These behaviors were accompanied by decreased AMPK/SIRT1 expression, NLRP3 inflammasome activation, and microglial activation in the hippocampus, resulting in significant inflammatory cytokine release.
    Summary · context
    To explore the role of the AMPK/SIRT1/NLRP3 pathway and neuroinflammation in postpartum maternal depression, rats were treated with AICAR (an AMPK agonist), MCC950 (an NLRP3 antagonist), and minocycline (a microglial activation inhibitor).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In sevoflurane-exposed postpartum rats, AICAR alleviated hippocampal microglial activation.

    In plain wordsIn postpartum rats exposed to sevoflurane, AICAR reduced microglial activation compared with exposure without rescue treatment.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseMicroglial activation
    Study

    ratn: not reported in source

    Postpartum rats exposed to sevoflurane during pregnancy
    Comparator
    Sevoflurane exposure without rescue treatment
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with AICAR, MCC950, minocycline, or ketamine alleviated these effects, while dorsomorphin reversed the antidepressant effects of ketamine.
    2 context sentences
    Summary · context
    These behaviors were accompanied by decreased AMPK/SIRT1 expression, NLRP3 inflammasome activation, and microglial activation in the hippocampus, resulting in significant inflammatory cytokine release.
    Summary · context
    To explore the role of the AMPK/SIRT1/NLRP3 pathway and neuroinflammation in postpartum maternal depression, rats were treated with AICAR (an AMPK agonist), MCC950 (an NLRP3 antagonist), and minocycline (a microglial activation inhibitor).
  8. 08AnimalAnimal study (in vivo)Mechanism

    In sevoflurane-exposed postpartum rats, AICAR alleviated inflammatory IL-1β release.

    In plain wordsIn postpartum rats exposed to sevoflurane, AICAR reduced IL-1β release compared with exposure without rescue treatment.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseIL-1β release
    Study

    ratn: not reported in source

    Postpartum rats exposed to sevoflurane during pregnancy
    Comparator
    Sevoflurane exposure without rescue treatment
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with AICAR, MCC950, minocycline, or ketamine alleviated these effects, while dorsomorphin reversed the antidepressant effects of ketamine.
    3 context sentences
    Summary · context
    These behaviors were accompanied by decreased AMPK/SIRT1 expression, NLRP3 inflammasome activation, and microglial activation in the hippocampus, resulting in significant inflammatory cytokine release.
    Summary · context
    Microglial activation and inflammasome expression were analyzed by immunofluorescence, and cytokine levels (IL-1β, IL-18, TNF-α) by ELISA.
    Summary · context
    To explore the role of the AMPK/SIRT1/NLRP3 pathway and neuroinflammation in postpartum maternal depression, rats were treated with AICAR (an AMPK agonist), MCC950 (an NLRP3 antagonist), and minocycline (a microglial activation inhibitor).
  9. 09AnimalAnimal study (in vivo)Mechanism

    In sevoflurane-exposed postpartum rats, AICAR alleviated decreased hippocampal SIRT1 expression.

    In plain wordsIn postpartum rats exposed to sevoflurane, AICAR restored SIRT1 expression compared with exposure without rescue treatment.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSIRT1 expression
    Study

    ratn: not reported in source

    Postpartum rats exposed to sevoflurane during pregnancy
    Comparator
    Sevoflurane exposure without rescue treatment
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with AICAR, MCC950, minocycline, or ketamine alleviated these effects, while dorsomorphin reversed the antidepressant effects of ketamine.
    2 context sentences
    Summary · context
    These behaviors were accompanied by decreased AMPK/SIRT1 expression, NLRP3 inflammasome activation, and microglial activation in the hippocampus, resulting in significant inflammatory cytokine release.
    Summary · context
    To explore the role of the AMPK/SIRT1/NLRP3 pathway and neuroinflammation in postpartum maternal depression, rats were treated with AICAR (an AMPK agonist), MCC950 (an NLRP3 antagonist), and minocycline (a microglial activation inhibitor).
  10. 10AnimalAnimal study (in vivo)Mechanism

    In sevoflurane-exposed postpartum rats, AICAR alleviated inflammatory IL-18 release.

    In plain wordsIn postpartum rats exposed to sevoflurane, AICAR reduced IL-18 release compared with exposure without rescue treatment.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseIL-18 release
    Study

    ratn: not reported in source

    Postpartum rats exposed to sevoflurane during pregnancy
    Comparator
    Sevoflurane exposure without rescue treatment
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with AICAR, MCC950, minocycline, or ketamine alleviated these effects, while dorsomorphin reversed the antidepressant effects of ketamine.
    3 context sentences
    Summary · context
    These behaviors were accompanied by decreased AMPK/SIRT1 expression, NLRP3 inflammasome activation, and microglial activation in the hippocampus, resulting in significant inflammatory cytokine release.
    Summary · context
    Microglial activation and inflammasome expression were analyzed by immunofluorescence, and cytokine levels (IL-1β, IL-18, TNF-α) by ELISA.
    Summary · context
    To explore the role of the AMPK/SIRT1/NLRP3 pathway and neuroinflammation in postpartum maternal depression, rats were treated with AICAR (an AMPK agonist), MCC950 (an NLRP3 antagonist), and minocycline (a microglial activation inhibitor).
  11. 11AnimalAnimal study (in vivo)Mechanism

    In sevoflurane-exposed postpartum rats, AICAR alleviated inflammatory TNF-α release.

    In plain wordsIn postpartum rats exposed to sevoflurane, AICAR reduced TNF-α release compared with exposure without rescue treatment.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseTNF-α release
    Study

    ratn: not reported in source

    Postpartum rats exposed to sevoflurane during pregnancy
    Comparator
    Sevoflurane exposure without rescue treatment
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with AICAR, MCC950, minocycline, or ketamine alleviated these effects, while dorsomorphin reversed the antidepressant effects of ketamine.
    3 context sentences
    Summary · context
    These behaviors were accompanied by decreased AMPK/SIRT1 expression, NLRP3 inflammasome activation, and microglial activation in the hippocampus, resulting in significant inflammatory cytokine release.
    Summary · context
    Microglial activation and inflammasome expression were analyzed by immunofluorescence, and cytokine levels (IL-1β, IL-18, TNF-α) by ELISA.
    Summary · context
    To explore the role of the AMPK/SIRT1/NLRP3 pathway and neuroinflammation in postpartum maternal depression, rats were treated with AICAR (an AMPK agonist), MCC950 (an NLRP3 antagonist), and minocycline (a microglial activation inhibitor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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