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Study · In vitro (cells) · rat · 2005

4 results

AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress.

Terai K, Hiramoto Y, Masaki M, Sugiyama S, Kuroda T, Hori M, Kawase I, Hirota H

Molecular and cellular biology1 Nov 2005Cited by 308 (Europe PMC)

PMID16227605 (opens in a new tab)PMCIDPMC1265833 (opens in a new tab)DOI10.1128/mcb.25.21.9554-9575.2005 (opens in a new tab)PepBankPUB-16227605
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In neonatal rat cardiomyocytes, AICAR pretreatment significantly inhibited hypoxia-induced CHOP expression.

    In plain wordsIn cells from newborn rat hearts, AICAR reduced CHOP expression induced by low oxygen.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseHypoxia-induced CHOP expression
    Study

    ratn: not reported in source

    neonatal rat cardiomyocytes under hypoxia
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also found that hypoxia-induced CHOP expression and cleavage of caspase 12 were significantly inhibited by pretreatment with 5-aminoimidazole-4-carboxyamide-1-beta-D-ribofuranoside (AICAR), a pharmacological activator of AMPK.
    1 context sentence
    Summary · context
    We therefore examined whether AMPK attenuates hypoxia-induced ER stress in neonatal rat cardiomyocytes.
  2. 02LabIn vitro (cells)Mechanism

    In neonatal rat cardiomyocytes, AICAR pretreatment significantly inhibited hypoxia-induced caspase 12 cleavage.

    In plain wordsIn cells from newborn rat hearts, AICAR reduced caspase 12 cleavage induced by low oxygen.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseHypoxia-induced caspase 12 cleavage
    Study

    ratn: not reported in source

    neonatal rat cardiomyocytes under hypoxia
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also found that hypoxia-induced CHOP expression and cleavage of caspase 12 were significantly inhibited by pretreatment with 5-aminoimidazole-4-carboxyamide-1-beta-D-ribofuranoside (AICAR), a pharmacological activator of AMPK.
    1 context sentence
    Summary · context
    We therefore examined whether AMPK attenuates hypoxia-induced ER stress in neonatal rat cardiomyocytes.

Studies that did not test the peptide alone2

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 03LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In neonatal rat cardiomyocytes, adenoviral dominant-negative AMPK expression significantly attenuated AICAR cardioprotection.

    In plain wordsIn rat heart cells, a virus expressing dominant-negative AMPK reduced protection associated with AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCardioprotection after dominant-negative AMPK expression
    Study

    ratn: not reported in source

    neonatal rat cardiomyocytes under hypoxia
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    In parallel, adenovirus expressing dominant-negative AMPK significantly attenuated the cardioprotective effects of AICAR.
    1 context sentence
    Summary · context
    We therefore examined whether AMPK attenuates hypoxia-induced ER stress in neonatal rat cardiomyocytes.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 04LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In neonatal rat cardiomyocytes, eEF2 kinase siRNA abolished AICAR cardioprotection by blocking eEF2 phosphorylation.

    In plain wordsIn rat heart cells, eEF2 kinase gene silencing abolished protection associated with AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCardioprotection after eEF2 kinase knockdown
    Study

    ratn: not reported in source

    neonatal rat cardiomyocytes under hypoxia
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    Knockdown of eEF2 phosphorylation using eEF2 kinase siRNA abolished these cardioprotective effects of AICAR.
    1 context sentence
    Summary · context
    We therefore examined whether AMPK attenuates hypoxia-induced ER stress in neonatal rat cardiomyocytes.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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