Skip to content

Study · Other design · 2026

11 results

Exogenous pyruvate restores mitochondrial bioenergetics by synergizing with the AMPK-mTOR-SIRT3 pathway to alleviate sepsis-associated acute kidney injury.

Wang Y, Wang W, Sun J, Zhou S, Ni L, Dong M, Wang X, Yuan Y, Wang J, Ren P, Fang W, Jin K

Chemico-biological interactions22 Apr 2026Cited by 1 (Europe PMC)

PMID42031090 (opens in a new tab)DOI10.1016/j.cbi.2026.112089 (opens in a new tab)PepBankPUB-42031090
Publisher pagePubMedAsk about this study
Jump to 11 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalOther designMechanism

    In SA-AKI models, adding AICAR to EP restored NAD+/NADH balance compared with EP alone.

    In plain wordsIn sepsis models, adding AICAR to EP restored NAD+/NADH balance compared with EP alone.

    Peptide
    AICAR (acadesine)
    Outcome
    MixedNAD+/NADH balance
    Study

    n: not reported in source

    SA-AKI mice and LPS-stimulated HK-2 cells
    Comparator
    EP alone
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, combined EP and AICAR treatment, rather than EP alone, alleviated mitochondrial dysfunction by restoring NAD+/NADH balance, increasing mitochondrial DNA (mtDNA) content, improving mitochondrial respiratory chain complex activity, and rebalancing mitochondrial fission-fusion dynamics.
  2. 02AnimalOther designMechanism

    In SA-AKI models, adding AICAR to EP increased mitochondrial DNA content compared with EP alone.

    In plain wordsIn sepsis models, adding AICAR to EP increased mitochondrial DNA content compared with EP alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMitochondrial DNA content
    Study

    n: not reported in source

    SA-AKI mice and LPS-stimulated HK-2 cells
    Comparator
    EP alone
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, combined EP and AICAR treatment, rather than EP alone, alleviated mitochondrial dysfunction by restoring NAD+/NADH balance, increasing mitochondrial DNA (mtDNA) content, improving mitochondrial respiratory chain complex activity, and rebalancing mitochondrial fission-fusion dynamics.
  3. 03AnimalOther designMechanism

    In SA-AKI models, adding AICAR to EP improved mitochondrial respiratory chain complex activity compared with EP alone.

    In plain wordsIn sepsis models, adding AICAR to EP improved mitochondrial respiratory chain activity compared with EP alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseRespiratory chain complex activity
    Study

    n: not reported in source

    SA-AKI mice and LPS-stimulated HK-2 cells
    Comparator
    EP alone
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, combined EP and AICAR treatment, rather than EP alone, alleviated mitochondrial dysfunction by restoring NAD+/NADH balance, increasing mitochondrial DNA (mtDNA) content, improving mitochondrial respiratory chain complex activity, and rebalancing mitochondrial fission-fusion dynamics.
  4. 04AnimalOther designMechanism

    In SA-AKI models, adding AICAR to EP rebalanced mitochondrial fission-fusion dynamics compared with EP alone.

    In plain wordsIn sepsis models, adding AICAR to EP balanced mitochondrial division and fusion compared with EP alone.

    Peptide
    AICAR (acadesine)
    Outcome
    MixedMitochondrial fission-fusion dynamics
    Study

    n: not reported in source

    SA-AKI mice and LPS-stimulated HK-2 cells
    Comparator
    EP alone
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, combined EP and AICAR treatment, rather than EP alone, alleviated mitochondrial dysfunction by restoring NAD+/NADH balance, increasing mitochondrial DNA (mtDNA) content, improving mitochondrial respiratory chain complex activity, and rebalancing mitochondrial fission-fusion dynamics.

Studies that did not test the peptide alone7

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 05AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In septic mice, combined EP and AICAR improved renal function.

    In plain wordsIn mice with sepsis, combined EP and AICAR improved kidney function.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseRenal function
    Study

    mousen: not reported in source

    Cecal ligation and puncture-induced SA-AKI mice
    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    Using a cecal ligation and puncture-induced SA-AKI mouse model and LPS-stimulated HK-2 cells, we demonstrated that EP synergized with the AMPK activator AICAR to significantly improve renal function, reduce injury markers and inflammation, and enhance survival.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 06AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In septic mice, combined EP and AICAR reduced renal injury markers.

    In plain wordsIn mice with sepsis, combined EP and AICAR reduced kidney injury markers.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseRenal injury markers
    Study

    mousen: not reported in source

    Cecal ligation and puncture-induced SA-AKI mice
    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    Using a cecal ligation and puncture-induced SA-AKI mouse model and LPS-stimulated HK-2 cells, we demonstrated that EP synergized with the AMPK activator AICAR to significantly improve renal function, reduce injury markers and inflammation, and enhance survival.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  3. 07AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Efficacy outcome

    In septic mice, combined EP and AICAR enhanced survival.

    In plain wordsIn mice with sepsis, combined EP and AICAR increased survival.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSurvival
    Study

    mousen: not reported in source

    Cecal ligation and puncture-induced SA-AKI mice
    Outcome group
    Mortality · Kidney and urinary

    Source sentences

    Summary
    Using a cecal ligation and puncture-induced SA-AKI mouse model and LPS-stimulated HK-2 cells, we demonstrated that EP synergized with the AMPK activator AICAR to significantly improve renal function, reduce injury markers and inflammation, and enhance survival.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  4. 08AnimalNot a test of AICAR (acadesine) aloneOther designMechanism

    In SA-AKI models, combined EP and AICAR reduced inflammation.

    In plain wordsIn sepsis models, combined EP and AICAR reduced inflammation.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseInflammation
    Study

    n: not reported in source

    SA-AKI mice and LPS-stimulated HK-2 cells
    Outcome group
    Inflammation markers · Kidney and urinary

    Source sentences

    Summary
    Using a cecal ligation and puncture-induced SA-AKI mouse model and LPS-stimulated HK-2 cells, we demonstrated that EP synergized with the AMPK activator AICAR to significantly improve renal function, reduce injury markers and inflammation, and enhance survival.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  5. 09AnimalNot a test of AICAR (acadesine) aloneOther designMechanism

    In SA-AKI models, combined EP and AICAR enhanced autophagy partly through SIRT3.

    In plain wordsIn sepsis models, combined EP and AICAR increased autophagy partly through SIRT3.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAutophagy
    Study

    n: not reported in source

    SA-AKI mice and LPS-stimulated HK-2 cells
    Outcome group
    Mitochondrial function · Kidney and urinary

    Source sentences

    Summary
    Combined EP and AICAR treatment also enhanced autophagy and reduced apoptosis, partly through a SIRT3-dependent mechanism downstream of AMPK-mTOR signaling.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  6. 10AnimalNot a test of AICAR (acadesine) aloneOther designMechanism

    In SA-AKI models, combined EP and AICAR reduced apoptosis partly through SIRT3.

    In plain wordsIn sepsis models, combined EP and AICAR reduced cell death partly through SIRT3.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseApoptosis
    Study

    n: not reported in source

    SA-AKI mice and LPS-stimulated HK-2 cells
    Outcome group
    Mitochondrial function · Kidney and urinary

    Source sentences

    Summary
    Combined EP and AICAR treatment also enhanced autophagy and reduced apoptosis, partly through a SIRT3-dependent mechanism downstream of AMPK-mTOR signaling.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  7. 11AnimalNot a test of AICAR (acadesine) aloneOther designMechanism

    In SA-AKI models, rapamycin or interferon-γ pretreatment enhanced or diminished the effects of combined EP and AICAR treatment.

    In plain wordsIn mouse and cell sepsis models, rapamycin or interferon-γ pretreatment enhanced or reduced the effects of combined EP and AICAR treatment.

    Peptide
    AICAR (acadesine)
    Outcome
    MixedModulation of combined treatment effects
    Study

    n: not reported in source

    SA-AKI mice and LPS-stimulated HK-2 cells
    Outcome group
    Receptor activity and mechanism · Kidney and urinary

    Source sentences

    Summary
    This effect was enhanced or diminished by pretreatment with rapamycin (Rapa) or interferon-γ (IFN-γ).
    1 context sentence
    Summary · context
    Combined EP and AICAR treatment also enhanced autophagy and reduced apoptosis, partly through a SIRT3-dependent mechanism downstream of AMPK-mTOR signaling.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.