AICAR (acadesine) studies: 330 papers with results
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- Alternative splice variant PGC-1α-b is strongly induced by exercise in human skeletal muscle.
Norrbom J · American journal of physiology. Endocrinology and metabolism · 2011
In vitro (cells) · 3 results
- Resveratrol protects against isoproterenol induced myocardial infarction in rats through VEGF-B/AMPK/eNOS/NO signalling pathway.
Feng L · Free radical research · 2019
In vitro (cells) · rat · 1 result
- AMP-activated protein kinase attenuates oxLDL uptake in macrophages through PP2A/NF-κB/LOX-1 pathway.
Chen B · Vascular pharmacology · 2016
In vitro (cells) · 13 results
- Adiponectin attenuates angiotensin II-induced oxidative stress in renal tubular cells through AMPK and cAMP-Epac signal transduction pathways.
Fang F · American journal of physiology. Renal physiology · 2013
In vitro (cells) · 1 result
- Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1.
Fodor T · PloS one · 2016
In vitro (cells) · 12 results
- Insulin Resistance Prevents AMPK-induced Tau Dephosphorylation through Akt-mediated Increase in AMPKSer-485 Phosphorylation.
Kim B · The Journal of biological chemistry · 2015
In vitro (cells) · mouse · 11 results
- AMPK attenuates microtubule proliferation in cardiac hypertrophy.
Fassett JT · American journal of physiology. Heart and circulatory physiology · 2013
In vitro (cells) · 8 results
- AMPK inhibition blocks ROS-NFκB signaling and attenuates endotoxemia-induced liver injury.
Guo Y · PloS one · 2014
In vitro (cells) · 11 results
- Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition.
Nguyen G · Biochemical and biophysical research communications · 2018
In vitro (cells) · 8 results
- Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside.
Rivas DA · The Journal of endocrinology · 2009
In vitro (cells) · 1 result
- AMPK alleviates endoplasmic reticulum stress by inducing the ER-chaperone ORP150 via FOXO1 to protect human bronchial cells from apoptosis.
Liu JQ · Biochemical and biophysical research communications · 2018
In vitro (cells) · 3 results
- Exercise-induced AMPK activation is involved in delay of skeletal muscle senescence.
Yoon KJ · Biochemical and biophysical research communications · 2019
In vitro (cells) · 2 results
- Metformin alleviates high glucose-induced ER stress and inflammation by inhibiting the interaction between caveolin1 and AMPKα in rat astrocytes.
Wang G · Biochemical and biophysical research communications · 2021
In vitro (cells) · rat · 1 result
- AMPK alleviates high uric acid-induced Na+-K+-ATPase signaling impairment and cell injury in renal tubules.
Xiao J · Experimental & molecular medicine · 2019
In vitro (cells) · 8 results
- Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes.
Ido Y · PloS one · 2012
In vitro (cells) · 5 results
- Lipid-induced insulin resistance is prevented in lean and obese myotubes by AICAR treatment.
Bikman BT · American journal of physiology. Regulatory, integrative and comparative physiology · 2010
In vitro (cells) · 4 results
- Irisin and ALCAT1 mediated aerobic exercise-alleviated oxidative stress and apoptosis in skeletal muscle of mice with myocardial infarction.
Ren W · Free radical biology & medicine · 2022
In vitro (cells) · 3 results
- AMPK-autophagy-mediated inhibition of microRNA-30a-5p alleviates morphine tolerance via SOCS3-dependent neuroinflammation suppression.
Wan L · Journal of neuroinflammation · 2022
In vitro (cells) · 5 results
- Exercise ameliorates lipid droplet metabolism disorder by the PLIN2-LIPA axis-mediated lipophagy in mouse model of non-alcoholic fatty liver disease.
Fang C · Biochimica et biophysica acta. Molecular basis of disease · 2024
In vitro (cells) · 6 results
- AMPK Prevents Palmitic Acid-Induced Apoptosis and Lipid Accumulation in Cardiomyocytes.
Adrian L · Lipids · 2017
In vitro (cells) · rat · 2 results
- Activation of AMP-activated protein kinase induce expression of FoxO1, FoxO3a, and myostatin after exercise-induced muscle damage.
Lee K · Biochemical and biophysical research communications · 2015
In vitro (cells) · 3 results
- Exercise Attenuates Myocardial Ischemia-Reperfusion Injury by Regulating Endoplasmic Reticulum Stress and Mitophagy Through M2 Acetylcholine Receptor.
Chen W · Antioxidants & redox signaling · 2024
In vitro (cells) · 2 results
- Role of Muscle-Specific Histone Methyltransferase (Smyd1) in Exercise-Induced Cardioprotection against Pathological Remodeling after Myocardial Infarction.
Liang Q · International journal of molecular sciences · 2020
In vitro (cells) · 2 results
- Acute Exercise Improves Insulin Clearance and Increases the Expression of Insulin-Degrading Enzyme in the Liver and Skeletal Muscle of Swiss Mice.
Kurauti MA · PloS one · 2016
In vitro (cells) · 2 results
- Metformin protects against insulin resistance induced by high uric acid in cardiomyocytes via AMPK signalling pathways in vitro and in vivo.
Jiao Z · Journal of cellular and molecular medicine · 2021
In vitro (cells) · 1 result
- AMP-activated protein kinase attenuates Wnt/β-catenin signaling in human osteoblastic Saos-2 cells.
Takatani T · Molecular and cellular endocrinology · 2011
In vitro (cells) · 1 result
- Resistance exercise upregulates Irisin expression and suppresses myocardial fibrosis following myocardial infarction via activating AMPK-Sirt1 and inactivating TGFβ1-Smad2/3.
Li H · Acta physiologica (Oxford, England) · 2024
In vitro (cells) · 3 results
- Thymoquinone Attenuates Acetaminophen Overdose-Induced Acute Liver Injury and Inflammation Via Regulation of JNK and AMPK Signaling Pathway.
Cui BW · The American journal of Chinese medicine · 2019
In vitro (cells) · 2 results
- Exercise-inducible factors to activate lipolysis in adipocytes.
Hashimoto T · Journal of applied physiology (Bethesda, Md. : 1985) · 2013
In vitro (cells) · 6 results
- Effects of treadmill exercise on the regulation of tight junction proteins in aged mice.
Shin HE · Experimental gerontology · 2020
In vitro (cells) · 1 result
- Disruption of AMPKalpha1 signaling prevents AICAR-induced inhibition of AS160/TBC1D4 phosphorylation and glucose uptake in primary rat adipocytes.
Gaidhu MP · Molecular endocrinology (Baltimore, Md.) · 2010
In vitro (cells) · rat · 17 results
- Platycodin D Ameliorates Type 2 Diabetes-Induced Myocardial Injury by Activating the AMPK Signaling Pathway.
Wang W · Journal of agricultural and food chemistry · 2024
In vitro (cells) · 1 result
- AICAR Protects Vascular Endothelial Cells from Oxidative Injury Induced by the Long-Term Palmitate Excess.
Samsonov MV · International journal of molecular sciences · 2021
In vitro (cells) · 7 results
- Compound C Protects Mice from HFD-Induced Obesity and Nonalcoholic Fatty Liver Disease.
Wang F · International journal of endocrinology · 2019
In vitro (cells) · 1 result
- Icariside II attenuates cardiac remodeling via AMPKα2/mTORC1 in vivo and in vitro.
Liu XY · Journal of pharmacological sciences · 2018
In vitro (cells) · rat · 1 result
- AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells.
Khorraminejad-Shirazi M · Stem cell research & therapy · 2020
In vitro (cells) · 14 results
- Activation of the metabolic sensor-AMP activated protein kinase reverses impairment of angiogenesis in aging myocardial microvascular endothelial cells. Implications for the aging heart.
Ahluwalia A · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · 2011
In vitro (cells) · rat · 3 results
- C1q/tumor necrosis factor-related protein-6 attenuates TNF-α-induced apoptosis in salivary acinar cells via AMPK/SIRT1-modulated miR-34a-5p expression.
Qu LH · Journal of cellular physiology · 2021
In vitro (cells) · 2 results
- Activation of AMP-activated protein kinase alleviates homocysteine-mediated neurotoxicity in SH-SY5Y cells.
Park YJ · Neurochemical research · 2013
In vitro (cells) · 7 results
- The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases.
Zajkowicz A · Mechanisms of ageing and development · 2011
In vitro (cells) · 9 results
- Nmnat2 attenuates amyloidogenesis and up-regulates ADAM10 in AMPK activity-dependent manner.
Cheng XS · Aging · 2021
In vitro (cells) · 3 results
- Chronic AICAR treatment prevents metabolic changes in cardiomyocytes exposed to free fatty acids.
Viglino C · Pflugers Archiv : European journal of physiology · 2019
In vitro (cells) · 11 results
- Chronic activation of AMP-activated protein kinase prevents 20-hydroxyeicosatetraenoic acid-induced endothelial dysfunction.
Ward NC · Clinical and experimental pharmacology & physiology · 2011
In vitro (cells) · 1 result
- Activation of AMP-activated protein kinase attenuates ethanol-induced ER/oxidative stress and lipid phenotype in human pancreatic acinar cells.
Srinivasan MP · Biochemical pharmacology · 2020
In vitro (cells) · 6 results
- Molecular Mechanism of Aerobic Exercise Ameliorating Myocardial Mitochondrial Injury in Mice with Heart Failure.
Jia H · International journal of molecular sciences · 2025
In vitro (cells) · mouse · 2 results
- Compound C Protects Against Cisplatin-Induced Nephrotoxicity Through Pleiotropic Effects.
Li F · Frontiers in physiology · 2020
In vitro (cells) · mouse · 1 result
- Aerobic exercise protects MI heart through miR-133a-3p downregulation of connective tissue growth factor.
Liu N · PloS one · 2024
In vitro (cells) · rat · 2 results
- FGF21 promotes myocardial angiogenesis and mediates the cardioprotective effects of exercise in myocardial infarction mice.
Bo W · Journal of applied physiology (Bethesda, Md. : 1985) · 2023
In vitro (cells) · 2 results
- AdipoRon Protects against Tubular Injury in Diabetic Nephropathy by Inhibiting Endoplasmic Reticulum Stress.
Xiong S · Oxidative medicine and cellular longevity · 2020
In vitro (cells) · 5 results
- Developmental endothelial locus-1 attenuates palmitate-induced apoptosis in tenocytes through the AMPK/autophagy-mediated suppression of inflammation and endoplasmic reticulum stress.
Park TJ · Bone & joint research · 2022
In vitro (cells) · 3 results