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Study · Ex vivo tissue · rat · 2000

2 results

UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase.

Zhou M, Lin BZ, Coughlin S, Vallega G, Pilch PF

American journal of physiology. Endocrinology and metabolism1 Sept 2000Cited by 108 (Europe PMC)

PMID10950831 (opens in a new tab)DOI10.1152/ajpendo.2000.279.3.e622 (opens in a new tab)PepBankPUB-10950831
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In isolated rat muscle, AICAR increased UCP-3 mRNA threefold compared with untreated muscle.

    In plain wordsIn lab tests, AICAR increased UCP-3 gene activity compared with untreated rat muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseUCP-3 mRNA
    Study

    ratn: not reported in source

    Isolated extensor digitorum longus muscle
    Comparator
    Untreated muscle
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    2 mM · 30 minAs given in this study (rat).

    Measurements

    UCP-3 mRNA increase
    3 fold
    AICAR versus untreated muscle

    Source sentences

    Summary
    Incubation of rat EDL muscle in vitro for 30 min with 2 mM AICAR causes a threefold increase in UCP-3 mRNA and a 1.5-fold increase of UCP-3 protein compared with untreated muscle.
    1 context sentence
    Summary · context
    We treated extensor digitorum longus (EDL) muscle with 5'-amino-4-imidazolecarboxamide ribonucleoside (AICAR), a compound that activates AMP-activated protein kinase (AMPK), an enzyme known to be stimulated during exercise and hypoxia.
  2. 02LabEx vivo tissueMechanism

    In isolated rat muscle, AICAR increased UCP-3 protein compared with untreated muscle.

    In plain wordsIn lab tests, AICAR increased UCP-3 protein compared with untreated rat muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseUCP-3 protein
    Study

    ratn: not reported in source

    Isolated extensor digitorum longus muscle
    Comparator
    Untreated muscle
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    2 mM · 30 minAs given in this study (rat).

    Measurements

    UCP-3 protein increase
    1.5 fold
    AICAR versus untreated muscle

    Source sentences

    Summary
    Incubation of rat EDL muscle in vitro for 30 min with 2 mM AICAR causes a threefold increase in UCP-3 mRNA and a 1.5-fold increase of UCP-3 protein compared with untreated muscle.
    1 context sentence
    Summary · context
    We treated extensor digitorum longus (EDL) muscle with 5'-amino-4-imidazolecarboxamide ribonucleoside (AICAR), a compound that activates AMP-activated protein kinase (AMPK), an enzyme known to be stimulated during exercise and hypoxia.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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