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Study · In vitro (cells) · mouse · 2018

3 results

Metformin improves obesity-associated inflammation by altering macrophages polarization.

Jing Y, Wu F, Li D, Yang L, Li Q, Li R

Molecular and cellular endocrinology18 Sept 2017Cited by 183 (Europe PMC)

PMID28935544 (opens in a new tab)DOI10.1016/j.mce.2017.09.025 (opens in a new tab)PepBankPUB-28935544
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In palmitate-stimulated BMDMs, AICAR decreased the proportion of M1 macrophages.

    In plain wordsIn cells stimulated with palmitate, AICAR reduced the proportion of inflammatory M1 macrophages.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseM1 macrophage proportion
    Study

    mousen: not reported in source

    Palmitate-stimulated bone marrow-derived macrophages
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, treatment with metformin and AICAR decreased the proportion of M1 macrophages and increased the proportion of M2 macrophages, as analyzed by flow cytometry, in palmitate-stimulated BMDMs.
    1 context sentence
    Summary · context
    Metformin, compound C (an AMPK inhibitor) and AICAR (an AMPK activator) were used for the in vitro intervention.
  2. 02LabIn vitro (cells)Mechanism

    In palmitate-stimulated BMDMs, AICAR increased the proportion of M2 macrophages.

    In plain wordsIn cells stimulated with palmitate, AICAR increased the proportion of M2 macrophages.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseM2 macrophage proportion
    Study

    mousen: not reported in source

    Palmitate-stimulated bone marrow-derived macrophages
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, treatment with metformin and AICAR decreased the proportion of M1 macrophages and increased the proportion of M2 macrophages, as analyzed by flow cytometry, in palmitate-stimulated BMDMs.
    1 context sentence
    Summary · context
    Metformin, compound C (an AMPK inhibitor) and AICAR (an AMPK activator) were used for the in vitro intervention.
  3. 03LabIn vitro (cells)Mechanism

    In palmitate-stimulated BMDMs, AICAR had a stronger effect on macrophage polarization than metformin.

    In plain wordsIn cells stimulated with palmitate, AICAR changed macrophage polarization more strongly than metformin.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMacrophage polarization versus metformin
    Study

    mousen: not reported in source

    Palmitate-stimulated bone marrow-derived macrophages
    Comparator
    Metformin
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, the effect of AICAR on macrophage polarization was stronger than that of metformin.
    2 context sentences
    Summary · context
    Moreover, treatment with metformin and AICAR decreased the proportion of M1 macrophages and increased the proportion of M2 macrophages, as analyzed by flow cytometry, in palmitate-stimulated BMDMs.
    Summary · context
    Metformin, compound C (an AMPK inhibitor) and AICAR (an AMPK activator) were used for the in vitro intervention.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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