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Study · In vitro (cells) · rat · 2008

1 result

Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy.

Kim J, Wende AR, Sena S, Theobald HA, Soto J, Sloan C, Wayment BE, Litwin SE, Holzenberger M, LeRoith D, Abel ED

Molecular endocrinology (Baltimore, Md.)18 Sept 2008Cited by 169 (Europe PMC)

PMID18801929 (opens in a new tab)PMCIDPMC2582541 (opens in a new tab)DOI10.1210/me.2008-0265 (opens in a new tab)PepBankPUB-18801929
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In neonatal rat cardiomyocytes, AICAR prevented IGF-I/insulin-induced hypertrophy.

    In plain wordsIn cells from newborn rats, AICAR prevented enlargement compared with IGF-I/insulin stimulation without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCardiomyocyte hypertrophy
    Study

    ratn: not reported in source

    Cultured neonatal rat cardiomyocytes
    Comparator
    IGF-I/insulin stimulation without AICAR
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In cultured neonatal rat cardiomyocytes, activation of AMPK with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) prevented IGF-I/insulin-induced cardiomyocyte hypertrophy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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