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Study · Ex vivo tissue · 2015

3 results

Activation of AMPK in human fetal membranes alleviates infection-induced expression of pro-inflammatory and pro-labour mediators.

Lim R, Barker G, Lappas M

Placenta26 Jan 2015Cited by 22 (Europe PMC)

PMID25659498 (opens in a new tab)DOI10.1016/j.placenta.2015.01.007 (opens in a new tab)PepBankPUB-25659498
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In human fetal membranes, AICAR decreased IL-6 stimulated by LPS, flagellin and poly(I:C).

    In plain wordsIn lab tests, AICAR reduced IL-6 in stimulated human fetal membranes.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseIL-6 production
    Study

    humann: not reported in source

    Stimulated human fetal membranes
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AMPK activators AICAR, phenformin and A769662 significantly decreased IL-6 and IL-8 stimulated by LPS, flagellin and poly(I:C).
    1 context sentence
    Summary · context
    To determine the effect of AMPK activators on pro-inflammatory cytokines, fetal membranes were pre-treated with AMPK activators then stimulated with bacterial products LPS and flagellin or viral dsDNA analogue poly(I:C).
  2. 02LabEx vivo tissueMechanism

    In human fetal membranes, AICAR decreased IL-8 stimulated by LPS, flagellin and poly(I:C).

    In plain wordsIn lab tests, AICAR reduced IL-8 in stimulated human fetal membranes.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseIL-8 production
    Study

    humann: not reported in source

    Stimulated human fetal membranes
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AMPK activators AICAR, phenformin and A769662 significantly decreased IL-6 and IL-8 stimulated by LPS, flagellin and poly(I:C).
    1 context sentence
    Summary · context
    To determine the effect of AMPK activators on pro-inflammatory cytokines, fetal membranes were pre-treated with AMPK activators then stimulated with bacterial products LPS and flagellin or viral dsDNA analogue poly(I:C).

Studies that did not test the peptide alone1

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 03LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In primary amnion cells, AMPK activators decreased IL-1β-induced MMP-9 expression.

    In plain wordsIn cells, AMPK activators reduced inflammation-induced MMP-9 expression.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseMMP-9 expression
    Study

    humann: not reported in source

    Primary amnion cells
    Outcome group
    Inflammation markers · Reproductive and sexual health

    Source sentences

    Summary
    Primary amnion cells treated with AMPK activators significantly decreased IL-1β-induced MMP-9 expression.
    1 context sentence
    Summary · context
    Primary amnion cells were used to determine the effect of AMPK activators on IL-1β-stimulated MMP-9 expression.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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