Synthetic analog · 9 amino acids · 1,069.2 Da

Desmopressin studies and research data

PepBank has 138 desmopressin studies with results. 135 of them gave desmopressin, with 695 results, grouped by what the studies measured. In each group, results from studies in people come first. Data as of 2026-10-30.

Searches 695 results and 1,099 papers. Newer studies from Europe PMC

Results in people

622

89% of 695 results

Results in animals

10% of 695 results

Results in lab cells

under 1% of 695 results

From computer models

0% of 695 results

The molecule

Desmopressin identity

Identifiers, parent molecule, targets and development stage, from curated data.

Desmopressin is a deamino-D-arginine analog of vasopressin. It acts mainly at vasopressin V2 receptors. Oral, nasal, sublingual, and injectable products have different doses.

Kind: Synthetic analog · 9 residues
Identifiers: ChEMBLCHEMBL1429 (opens in a new tab)PubChem CID5311065 (opens in a new tab)UNIIENR1LLB0FP (opens in a new tab)DrugBankDB00035 (opens in a new tab)CAS16679-58-6
Parent: Analog of Arginine vasopressinDesmopressin replaces the amino-bearing Cys1 unit of arginine vasopressin with 3-mercaptopropionyl and replaces L-Arg8 with D-Arg8. UniProt P01185 identifies the human precursor, not desmopressin.
Development: Approved in the US and EU (Ddavp)An approved medicinal product exists. Availability and other indications can differ. Source (opens in a new tab)

Targets

Molecular targets with action and evidence source
Target	Action	Evidence
Vasopressin V2 receptorAVPR2P30518 (opens in a new tab)	Agonist	Official prescribing information, mechanism of actionSource (opens in a new tab)

Sequence and structure

Residues, differences from the parent, calculated properties and 3D structure. Source values and calculated values are shown separately.

Sequence

9 amino acids · 2 modifications · 1 disulfide bond

YFQNCPG

Parent: Arginine vasopressin

No sequence is listed for the parent, so no alignment is shown.Desmopressin replaces the amino-bearing Cys1 unit of arginine vasopressin with 3-mercaptopropionyl and replaces L-Arg8 with D-Arg8. UniProt P01185 identifies the human precursor, not desmopressin.

Properties

From identity sources

Formula: C₄₆H₆₄N₁₄O₁₂S₂
Molecular weight: 1,069.2 g/mol
Monoisotopic mass: 1,068.427 Da

GSRS UNII ENR1LLB0FP(opens in a new tab)retrieved 2026-10-27
PubChem CID 5311065(opens in a new tab)retrieved 2026-10-27
Curated DDAVP US label(opens in a new tab)retrieved 2026-10-27

Calculated from the sequence

pKa set

Some values cannot be calculated. The sequence has a non-canonical residue (X). Residue tables cover only the 20 standard amino acids.

Average mass: Not calculated
Monoisotopic mass: Not calculated
Isoelectric point (pI): Not calculated
Net charge at pH 7.4: Not calculated
GRAVY (hydropathy): Not calculated
Extinction coefficient, 280 nm (Cys reduced): 1,490 M⁻¹ cm⁻¹; 5500 x Trp + 1490 x Tyr · Pace et al. 1995 (ExPASy ProtParam); No Trp: ExPASy reports more than 10 % error without Trp.
Instability index: Not calculated
Aliphatic index: Not calculated
Boman index: Not calculated
Hydrophobic moment (μH): Not calculated

1 non-canonical residue (X) is not included in calculated values.
The N-terminal group is not modeled.
The record lists 1 disulfide bonds but the sequence has only 1 Cys.
D-amino acids have the same mass and charge as L forms. Hydrophobicity scales were measured on L forms.
Defined and validated for proteins; use with care for short peptides.
Assumes an ideal alpha helix. Many short peptides are not helical.

@pepdb/chem 0.2.0 · EMBOSS pKa set · ExPASy residue masses

Net charge by pH

No charge curve

The sequence has a non-canonical residue (X). Residue tables cover only the 20 standard amino acids.

Composition

Aromatic22% (2)F Y
Positive11% (1)R
Polar22% (2)N Q
Special33% (3)C G P
Non-canonical11% (1)X

9 residues. Each residue counts in one class; F and W count as aromatic.

A Ala0 · 0%

I Ile0 · 0%

L Leu0 · 0%

M Met0 · 0%

V Val0 · 0%

F Phe1 · 11%

W Trp0 · 0%

Y Tyr1 · 11%

H His0 · 0%

K Lys0 · 0%

R Arg1 · 11%

D Asp0 · 0%

E Glu0 · 0%

N Asn1 · 11%

Q Gln1 · 11%

S Ser0 · 0%

T Thr0 · 0%

C Cys1 · 11%

G Gly1 · 11%

P Pro1 · 11%

X Xaa1 · 11%

3D structure

PredictedAlphaFold DB · P01185

Loads the 3D viewer (3Dmol.js, about 150 KB) and the model file from AlphaFold DB (EMBL-EBI).

2D structure

Draws the structure in your browser with RDKit (about 2.3 MB, loaded once).

SMILES fromPubChem CID 5311065(opens in a new tab)

C1C[C@H](N(C1)C(=O)[C@@H]2CSSCCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N

Results by area

Desmopressin results by year and outcome

Counts are exact and come from studies that gave the peptide.

Desmopressin has 1,099 linked papers. PepBank read up to 120 of the most-cited studies that gave it to people, up to 20 other studies, and the main trials.

Studies by year

138 of 1,099 studies have results (13%), published 1977 to 2023. Top row: every study. Bottom row: studies with results about Desmopressin, by class. The rows use different scales.

Studies
Human
Animal
Lab
Computer model
Natural levels, tool or combination only

Studies1,099 in all, 1973 to 2026

Studies with results138 in all, 1977 to 2023

Retracted studies are left out. A study with results in two classes counts in both.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

What the studies measured

People first in each area, then animals, then lab cells. Counts are exact and come from studies that gave the peptide.

Desmopressin studies on blood and clotting

234 results · people 224 · animals 10 · lab 0

Top 5 of 234 results

In elective cardiac surgery, desmopressin and placebo produced similar blood loss.The New England journal of medicine, 1989
In cardiac surgery patients with abnormal clot tests, clot ratios were higher with desmopressin than with placebo.Lancet, 1999
In children after cardiac surgery, desmopressin did not reduce blood loss compared with placebo.The Journal of thoracic and cardiovascular surgery, 1993
In children after cardiac surgery, desmopressin did not reduce blood replacement compared with placebo.The Journal of thoracic and cardiovascular surgery, 1993
In cardiac surgery patients with abnormal clot tests, desmopressin reduced 24-hour blood loss compared with placebo.Lancet, 1999

Desmopressin studies on kidneys and bladder

239 results · people 221 · animals 18 · lab 0

Top 5 of 239 results

In Japanese nocturia patients, desmopressin 25 μg reduced night-time urination more than placebo.BJU international, 2013
In patients with severe bedwetting, desmopressin and alarm had similar rates of at least 50% fewer wet nights.Journal of pediatric urology, 2011
In children with enuresis and voiding dysfunction, adding desmopressin to oxybutynin showed 71% success versus 54% with oxybutynin alone.European urology, 1997
In children with bedwetting, first-period dry nights averaged 4.3 per week with desmopressin and 2.1 with placebo.The Journal of urology, 1991
In adults with nocturia, higher desmopressin doses were linked to lower urine volumes than lower doses.Neurourology and urodynamics, 2012

Desmopressin studies on side effects

74 results · people 73 · animals 1 · lab 0

Top 5 of 74 results

In men with nocturia, adverse events affected similar numbers: 17% with desmopressin and 25% with placebo.BJU international, 2002
In women with overactive bladder, safety was similar with added desmopressin and tolterodine alone.Lower urinary tract symptoms, 2018
In men with nocturia, low sodium occurred in 2 subjects on desmopressin 50 μg versus 9 on 75 μg.The Journal of urology, 2013
In hepatectomy patients, the study reported no changes in plasma electrolyte levels with desmopressin or saline.Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003
In elective aortic operation patients, major clot-related complications were similar with DDAVP and placebo.Journal of vascular surgery, 1995

Desmopressin studies on hormones

14 results · people 14 · animals 0 · lab 0

Top 5 of 14 results

After desmopressin, 11/18 subjects responded based on ACTH and cortisol output.Clinical endocrinology, 1999
In children with diabetes insipidus, DDAVP did not change cortisol levels during sleep.The Journal of pediatrics, 1978
In chronic schizophrenia, four neurochemical concentrations and the growth hormone response to clonidine did not change during DDAVP therapy.Neuropsychobiology, 1989
In healthy volunteers, plasma renin activity increased after desmopressin.Clinical endocrinology, 1986
In healthy volunteers, cortisol increased after desmopressin.Clinical endocrinology, 1986

Desmopressin studies on heart and blood vessels

14 results · people 13 · animals 1 · lab 0

Top 5 of 14 results

In patients with POTS, desmopressin did not change standing blood pressure compared with placebo.Heart rhythm, 2012
In patients with POTS, desmopressin lowered standing heart rate compared with placebo.Heart rhythm, 2012
In aspirin-pretreated coronary bypass patients, thrombotic complications did not differ between desmopressin and placebo.The Journal of thoracic and cardiovascular surgery, 1992
In elderly subjects with nocturia, ankle circumference did not change during desmopressin treatment.BJU international, 1999
In elective CABG, hypotension occurred during infusion in four DDAVP patients and no controls.Journal of cardiothoracic anesthesia, 1989

Desmopressin studies on sleep

13 results · people 13 · animals 0 · lab 0

Top 3 of 13 results

In adults with nocturia, higher desmopressin doses were linked to longer first sleep periods than lower doses.Neurourology and urodynamics, 2012
In men with nocturia, desmopressin improved sleep quality compared with placebo.The Journal of urology, 2013
In women with nocturia, desmopressin delayed first urination by 49 minutes compared with placebo.The Journal of urology, 2013

Desmopressin studies on use, access and costs

12 results · people 12 · animals 0 · lab 0

Top 5 of 12 results

In children and adolescents with bedwetting, 56% preferred desmopressin MELT versus 44% preferring tablets, without a significant difference.International journal of clinical practice, 2007
In patients with severe bedwetting, early withdrawal occurred in 7% with desmopressin versus 32% with alarm.Journal of pediatric urology, 2011
In children with bedwetting, withdrawal occurred in 5.2% with desmopressin versus 30.7% with an alarm.The Journal of urology, 2015
In cirrhotic patients undergoing tooth extraction, desmopressin cost $700/patient versus $1,173/patient for transfusion.Journal of oral and maxillofacial surgery, 2010
In children and adolescents with bedwetting, preference for desmopressin formulations depended on age.International journal of clinical practice, 2007

Desmopressin studies on pain

9 results · people 9 · animals 0 · lab 0

Top 5 of 9 results

In patients with renal colic, pain at 10 minutes did not differ significantly between desmopressin and diclofenac.BJU international, 2001
In spinal fusion patients, analgesic treatment duration did not differ significantly with desmopressin versus placebo before adjustment.Annals of internal medicine, 1987
In renal colic, pain at 20 minutes was 5.0 with desmopressin and 3.7 with diclofenac; the authors call all treatments equally effective then.BJU international, 2001
In spinal fusion patients, desmopressin reduced analgesic treatment duration versus placebo after adjustment for scoliosis origin.Annals of internal medicine, 1987
In patients with renal colic, pain at 30 minutes was higher with desmopressin than with diclofenac.BJU international, 2001

Desmopressin studies on blood levels and clearance

22 results · people 8 · animals 14 · lab 0

Top 3 of 22 results

In healthy volunteers taking ticagrelor, added desmopressin did not change ticagrelor pharmacokinetics compared with ticagrelor alone.Journal of clinical pharmacy and therapeutics, 2014
In hemophilic volunteers, intravenous DDAVP produced higher peak drug levels than subcutaneous DDAVP.Thrombosis and haemostasis, 1987
In patients with central diabetes insipidus, blood DDAVP peaked up to 4 h after administration.The Journal of clinical endocrinology and metabolism, 1978

Desmopressin studies on memory and thinking

7 results · people 7 · animals 0 · lab 0

Top 3 of 7 results

In chronic schizophrenia, DDAVP showed a trend toward better short- to medium-term memory.Neuropsychobiology, 1989
In healthy young men, DDAVP improved sentence memory compared with controls.Peptides, 1984
In healthy young men, desmopressin improved immediate memory during the first session, especially in low-verbal subjects.Peptides, 1985

Desmopressin studies on daily life and fitness

6 results · people 6 · animals 0 · lab 0

Top 5 of 6 results

In women with overactive bladder, nocturia impact scores were similar with added desmopressin and tolterodine alone.Lower urinary tract symptoms, 2018
In men with nocturia, desmopressin improved quality of life compared with placebo.The Journal of urology, 2013
In patients with multiple sclerosis, eighty per cent preferred desmopressin to placebo.Journal of neurology, neurosurgery, and psychiatry, 1998
In patients with POTS, desmopressin improved symptoms at 2 hours compared with placebo.Heart rhythm, 2012
In women with nocturnal polyuria, added desmopressin did not significantly improve nocturia impact scores compared with tolterodine alone.Lower urinary tract symptoms, 2018

Desmopressin studies on survival and serious illness

7 results · people 5 · animals 2 · lab 0

Top 5 of 7 results

In severe leptospirosis with lung involvement, eight desmopressin recipients died versus three controls. Mortality did not differ significantly.Clinical microbiology and infection, 2010
In kidney-biopsy patients, desmopressin shortened hospital stay compared with placebo.American journal of kidney diseases, 2011
In dogs with grade 2 or 3 mammary cancer, desmopressin prolonged survival compared with placebo.Journal of the American Animal Hospital Association, 2011
In severe leptospirosis with lung involvement, eight desmopressin recipients died compared with four dexamethasone recipients.Clinical microbiology and infection, 2010
In dogs with grade 1 mammary tumors, survival did not significantly differ between desmopressin and placebo.Journal of the American Animal Hospital Association, 2011

Desmopressin studies on receptors and cell signals

10 results · people 3 · animals 7 · lab 0

Top 4 of 10 results

In healthy volunteers taking ticagrelor, added desmopressin did not change platelet aggregation inhibition compared with ticagrelor alone.Journal of clinical pharmacy and therapeutics, 2014
In mice, desmopressin was linked to activation of a kidney sugar-processing pathway, also seen with heat stress.American journal of physiology. Renal physiology, 2017
In breast cancer patients, desmopressin treatment around surgery was linked to higher levels of a blood-clotting protein.SpringerPlus, 2015
In healthy volunteers taking ticagrelor, added desmopressin increased platelet reactivity compared with ticagrelor alone.Journal of clinical pharmacy and therapeutics, 2014

Desmopressin studies on sex hormones and fertility

3 results · people 3 · animals 0 · lab 0

3 results

In healthy volunteers, LH did not change significantly after desmopressin.Clinical endocrinology, 1986
In healthy volunteers, FSH did not change significantly after desmopressin.Clinical endocrinology, 1986
In healthy volunteers, prolactin did not change significantly after desmopressin.Clinical endocrinology, 1986

Desmopressin studies on salt, water and minerals

10 results · people 2 · animals 8 · lab 0

Top 5 of 10 results

In patients treated with D.D.A.V.P., blood osmolality showed no consistent change compared with before drug administration.Lancet, 1977
In rats receiving hypotonic fluid, urine flow progressively increased during DDAVP infusion.The American journal of physiology, 1982
In patients treated with D.D.A.V.P., urine osmolality showed no consistent change compared with before drug administration.Lancet, 1977
In rats receiving hypotonic fluid, urine concentration progressively decreased during DDAVP infusion.The American journal of physiology, 1982
In rats receiving hypotonic fluid, free water reabsorption progressively decreased during DDAVP infusion.The American journal of physiology, 1982

Desmopressin studies on growth hormone and growth

2 results · people 2 · animals 0 · lab 0

2 results

In healthy volunteers, GH did not change significantly after desmopressin.Clinical endocrinology, 1986
In children with diabetes insipidus, DDAVP did not change growth hormone levels during sleep.The Journal of pediatrics, 1978

Desmopressin studies on weight and appetite

2 results · people 2 · animals 0 · lab 0

2 results

In children with relapsed bedwetting, continued desmopressin treatment had no effect on body weight.The Journal of urology, 1991
In elderly subjects with nocturia, body weight did not change during desmopressin treatment.BJU international, 1999

Desmopressin studies on cancer

13 results · people 1 · animals 11 · lab 1

Top 3 of 13 results

In breast cancer patients, desmopressin treatment was linked to fewer circulating tumor cells after surgery.SpringerPlus, 2015
In mice with experimental breast cancer spread to lungs, desmopressin suppressed spread less than the tested analogue.International journal of oncology, 2015
In mice with mammary cancer, desmopressin reduced blood vessel formation in growing tumors.Breast cancer research and treatment, 2013

Desmopressin studies on brain and nerves

1 result · people 1 · animals 0 · lab 0

1 result

In brain haemorrhage patients taking antiplatelets, death or dependency occurred less often with desmopressin than placebo.The Lancet. Neurology, 2023

Desmopressin studies on mood, stress and behavior

1 result · people 1 · animals 0 · lab 0

1 result

In chronic schizophrenia, DDAVP significantly improved negative symptoms during continued neuroleptic therapy.Neuropsychobiology, 1989

Desmopressin studies on skin, hair and wounds

1 result · people 1 · animals 0 · lab 0

1 result

In subjects with cranial diabetes insipidus, facial temperature increased after desmopressin.Clinical endocrinology, 1986

Desmopressin studies on surgery and procedures

1 result · people 1 · animals 0 · lab 0

1 result

In children after cardiac surgery, bleeding time, urine output, hemodynamics, and coagulation tests did not differ significantly between desmopressin and placebo.The Journal of thoracic and cardiovascular surgery, 1989

Trials and papers

Desmopressin trials

Registered trials that test the peptide, with phase, status and dates. A dot marks trials with posted results.

StatusPhase

102 trials match. Highest phase first. Data from ClinicalTrials.gov.

Trials on this page (25 of 102)

25 of 102 trials

Completed
Ongoing
Not yet recruiting
Stopped
Estimated dates (est.)
Results posted

20052010201520202025

Ph 4
Desmopressin in the Treatment of Mixed Nocturia With Nocturnal Polyuria and Low Nocturnal Bladder Capacity
NCT00902655
Apr 2004 to Dec 2005
Ph 4
Desmopressin in Cardiac Surgery
NCT00337766
Jun 2006 to Sept 2010
Ph 4
1-deamino 8-d-arginine Vasopressin (DDAVP) in Percutaneous Ultrasound-guided Renal Biopsy
NCT00748072
Aug 2008 to Dec 2009
Ph 4
DEPOPA
NCT00806468
Feb 2009 to est. Feb 2011
Terminated
Terminated
Ph 4
Desmopressin as Treatment for Postoperative Bleeding After Cardiac Surgery
NCT00885924
Mar 2009 to Feb 2012
Terminated
Terminated
Ph 4
Severe Aortic Stenosis and Acquired Von Willebrand´s Disease: The Impact of Desmopressin in Valve-Replacement Surgery
NCT01994330
Jun 2009 to Feb 2010
Ph 4
TM
NCT01036841
Dec 2009 to Apr 2010
Ph 4
SLEEP
NCT01645475
Apr 2011 to Aug 2012
Ph 4
Desmopressin Melt Therapy in Patients With Nocturnal Polyuria: a Pharmacokinetic/Dynamic Study
NCT01435083
Nov 2011 to Jul 2013
Ph 4
Desmopressin Melt Therapy in Nocturnal Polyuria Patients: Pharmacodynamic Study
NCT01439997
26 Mar 2012 to 1 Feb 2015

Browse all 102 matching trials in the list below

25 trials · 2 ongoing · 13 completed · 4 stopped early · 2 with posted results · source ClinicalTrials.gov (opens in a new tab)

Enrolling by invitationPhase 4NCT07712328

Randomized Controlled Clinical Study on the Prophylactic Intraoperative Use of Desmopressin in Complex Sellar Region Tumors

Zhaoyun Zhangn = 1522 Jun 2026 to est. 1 Sept 2028

Craniopharyngiomas · Pituitary Macroadenoma · Sellar and Suprasellar Masses

Trial page ClinicalTrials.govUpdated 17 Jul 2026

Enrolling by invitationPhase 4NCT06622187

Bleeding Prevention With Desmopressin for Allograft Kidney Biopsies

Hospital de Clinicas de Porto Alegren = 9614 Aug 2024 to est. 14 Jun 2026

Bleeding · Transplant, Kidney · Desmopressin · Kidney Biopsy

Trial page ClinicalTrials.govUpdated 11 Sept 2025

TerminatedPhase 4Results postedNCT04420585

Desmopressin for Bedwetting in Children With SCD

Montefiore Medical Centern = 87 Jul 2020 to 12 Jun 2023

Nocturnal Enuresis · Anemia, Sickle Cell

Trial page ClinicalTrials.govUpdated 7 May 2024

Status unknownPhase 4NCT06255366

Analysis of the Clinical Efficacy of Intravenous Application of Hemostatic Drugs in Improving the Clarity of Vision Under Endoscope, Perioperative Bleeding Volume and Anti-inflammatory Effect of Spinal Endoscopic Lumbar Fusion

Chengdu University of Traditional Chinese Medicinen = 126est. 28 Mar 2024 to est. 29 Jun 2025

Lumbar Spondylolisthesis · Arthrosis; Spine

Trial page ClinicalTrials.govUpdated 15 Mar 2024

CompletedPhase 4NCT03389412

The Effect of Selecting Treatment With Desmopressin or Alarm to Children With Enuresis Based on Home Recordings.

University of Aarhusn = 3241 Oct 2017 to 3 Jan 2023

Enuresis, Nocturnal

Trial page ClinicalTrials.govUpdated 2 Aug 2023

Status unknownPhase 4NCT05945420

Adding Desmopressin to Tamsulosin for Treatment of BPH

Mansoura Universityn = 160est. 20 Jul 2023 to est. 10 Feb 2024

Nocturnal Polyurea in Patients With BPH

Trial page ClinicalTrials.govUpdated 14 Jul 2023

CompletedPhase 4NCT01439997

Desmopressin Melt Therapy in Nocturnal Polyuria Patients: Pharmacodynamic Study

University Hospital, Ghentn = 526 Mar 2012 to 1 Feb 2015

Nocturia

Trial page ClinicalTrials.govUpdated 15 Dec 2022

CompletedPhase 4NCT01645475

Desmopressin Melt: Impact on Sleep and Daytime Functioning

University Hospital, Ghentn = 30Apr 2011 to Aug 2012

Monosymptomatic Nocturnal Enuresis

Trial page ClinicalTrials.govUpdated 15 Dec 2022

Status unknownPhase 4NCT04545931

Posterior Tibial Nerve Stimulation Vs Desmopressin In Children With Primary Monosymptomatic Nocturnal Enuresis

Cairo Universityn = 8015 Mar 2020 to est. 15 Dec 2020

Primary Monosymptomatic Nocturnal Enuresis

Trial page ClinicalTrials.govUpdated 11 Sept 2020

CompletedPhase 4NCT03379974

Exercise Versus DDAVP in Patients With Mild Hemophilia A

Nationwide Children's Hospitaln = 3231 Jul 2018 to 5 Dec 2019

Hemophilia A

Trial page ClinicalTrials.govUpdated 25 Feb 2020

WithdrawnPhase 4NCT03676361

To Evaluate the Renal Tubular Function Pre and Post Nephrectomy in Living Donors

University of Kansas Medical Centern = 029 Aug 2018 to 26 Apr 2019

Kidney Damage

Trial page ClinicalTrials.govUpdated 20 May 2019

CompletedPhase 4NCT01036841

Influence of Food-intake on Desmopressin Oral Tablets and MELT-formulation

University Hospital, Ghentn = 24Dec 2009 to Apr 2010

Enuresis · Polyuria

Trial page ClinicalTrials.govUpdated 6 Feb 2019

CompletedPhase 4NCT02584231

Pharmacokinetics and Pharmacodynamics of Desmopressin Oral Lyophilisate Formulation in the Paediatric Population

University Ghentn = 259 Sept 2015 to 1 Feb 2019

Monosymptomatic Nocturnal Enuresis

Trial page ClinicalTrials.govUpdated 6 Feb 2019

CompletedPhase 4NCT03510975

A New Check-list Method for Nocturnal Enuresis

Ankara Training and Research Hospitaln = 751 Jan 2015 to 1 Mar 2018

Nocturnal Enuresis

Trial page ClinicalTrials.govUpdated 1 May 2018

Status unknownPhase 4NCT03136003

DDAVP vs. Exercise in Patients With Mild Hemophilia A

The Hospital for Sick Childrenn = 304 Jul 2017 to est. Aug 2018

Mild Haemophilia A Without Inhibitor

Trial page ClinicalTrials.govUpdated 4 Dec 2017

Status unknownPhase 4NCT03343418

Effects of Prophylactic Desmopressin on Blood Coagulation Parameters in Heart Valve Surgery

Instituto do Coracaon = 108Feb 2015 to est. Nov 2017

C.Surgical Procedure; Cardiac · Blood Coagulation Disorders

Trial page ClinicalTrials.govUpdated 17 Nov 2017

CompletedPhase 4NCT02125188

Effects of Desmopressin on Blood Loss and the Quality of the Surgical Field During Endoscopic Sinus Surgery

Tao Zhangn = 60Jan 2014 to Aug 2014

Patients Undergoing Endoscopic Sinus Surgery

Trial page ClinicalTrials.govUpdated 6 Jun 2017

CompletedPhase 4NCT01994330

Severe Aortic Stenosis and Acquired Von Willebrand´s Disease: The Impact of Desmopressin in Valve-Replacement Surgery

Pontificia Universidad Catolica de Chilen = 13Jun 2009 to Feb 2010

Acquired Von Willebrand Disease Secondary to Severe Aortic Stenosis · Heye´s Syndrome · Severe Aortic Stenosis

Trial page ClinicalTrials.govUpdated 5 Apr 2017

CompletedPhase 4NCT00337766

Desmopressin in Cardiac Surgery

Università Vita-Salute San RaffaeleJun 2006 to Sept 2010

Hemorrhage · Blood Loss, Surgical · Postoperative Hemorrhage

Trial page ClinicalTrials.govUpdated 21 Oct 2015

TerminatedPhase 4NCT00885924

Desmopressin as Treatment for Postoperative Bleeding After Cardiac Surgery

St. Olavs Hospitaln = 17Mar 2009 to Feb 2012

Hemorrhage · Postoperative Blood Loss

Trial page ClinicalTrials.govUpdated 8 Apr 2015

CompletedPhase 4Results postedNCT00748072

1-deamino 8-d-arginine Vasopressin (DDAVP) in Percutaneous Ultrasound-guided Renal Biopsy

University of Barin = 162Aug 2008 to Dec 2009

Kidney Failure

Trial page ClinicalTrials.govUpdated 13 Jan 2015

CompletedPhase 4NCT01435083

Desmopressin Melt Therapy in Patients With Nocturnal Polyuria: a Pharmacokinetic/Dynamic Study

University Hospital, Ghentn = 50Nov 2011 to Jul 2013

Nocturnal Polyuria

Trial page ClinicalTrials.govUpdated 5 Dec 2014

Status unknownPhase 4NCT01582542

Desmopressin for Improving Nocturnal Enuresis in Patients After Radical Cystectomy With Bladder Reconstruction

Rabin Medical Centern = 50Apr 2012 to est. Mar 2014

Nocturnal Enuresis

Trial page ClinicalTrials.govUpdated 20 Apr 2012

TerminatedPhase 4NCT00806468

Effect of Desmopressin on the Nocturnal Micturition Frequency in Patients With Parkinson Disease

Johannes Gutenberg University Mainzn = 1Feb 2009 to est. Feb 2011

Parkinson Disease

Trial page ClinicalTrials.govUpdated 20 Dec 2010

CompletedPhase 4NCT00902655

Desmopressin in the Treatment of Mixed Nocturia With Nocturnal Polyuria and Low Nocturnal Bladder Capacity

Samsung Medical Centern = 103Apr 2004 to Dec 2005

Nocturia

Trial page ClinicalTrials.govUpdated 15 May 2009

19 more mention it but do not test it. They are not trials of Desmopressin: they only measure it (a blood level or an eligibility term) or name it in their text.

Papers

Studies on this peptide. Some have results. The others have none yet.

Sort

Design

1,099 studies match. Retracted studies are left out.

Showing 25 of 1,099 studiesquery qry_3fe66cd8ca2d39b9bdbb8914

Studies with results

138 studies in all, 8 on this page

Case report or series · 1977

9 results

1-Deamino-8-d-arginine vasopressin: a new pharmacological approach to the management of haemophilia and von Willebrands' diseases.

Mannucci et al. 1977Lancet (London, England)n = 8cited by 372

PMID 67283DOI 10.1016/s0140-6736(77)91197-7PUB-00067283

Full text at the publisher9 results where Desmopressin was given

Publisher page See results (9)

Randomized controlled trial · 1986

4 results

Treatment with desmopressin acetate to reduce blood loss after cardiac surgery. A double-blind randomized trial.

Salzman et al. 1986The New England journal of medicinen = 70cited by 275

PMID 3517650DOI 10.1056/nejm198605293142202PUB-03517650

Full text at the publisher4 results where Desmopressin was given

Publisher page See results (4)

Animal study (in vivo) · guinea pig · 2004

6 results

Transdermal delivery of desmopressin using a coated microneedle array patch system.

Cormier et al. 2004Journal of controlled release : official journal of the Controlled Release Societycited by 231

PMID 15212882DOI 10.1016/j.jconrel.2004.04.003PUB-15212882

Full text at the publisher5 results where Desmopressin was given (plus 1 on tools or combinations, listed separately)

Publisher page See results (6)

Randomized controlled trial · 2002

8 results

Efficacy of desmopressin in the treatment of nocturia: a double-blind placebo-controlled study in men.

Mattiasson et al. 2002BJU internationaln = 151cited by 144

PMID 12010228DOI 10.1046/j.1464-410x.2002.02791.xPUB-12010228

Full text at the publisher8 results where Desmopressin was given

Publisher page See results (8)

Randomized controlled trial · 1991

3 results

Hemostatic effects of tranexamic acid and desmopressin during cardiac surgery.

Horrow et al. 1991Circulationcited by 109

PMID 1934382DOI 10.1161/01.cir.84.5.2063PUB-01934382

Rights unknown3 results where Desmopressin was given

Source link See results (3)

Randomized controlled trial · 1989

2 results

A trial of desmopressin (1-desamino-8-D-arginine vasopressin) to reduce blood loss in uncomplicated cardiac surgery.

Hackmann et al. 1989The New England journal of medicinen = 150cited by 100

PMID 2682243DOI 10.1056/nejm198911233212104PUB-02682243

Full text at the publisher2 results where Desmopressin was given

Publisher page See results (2)

Randomized controlled trial · 2007

4 results

Desmopressin in the treatment of nocturia: a double-blind, placebo-controlled study.

van Kerrebroeck et al. 2007European urologyn = 127cited by 97

PMID 17280773DOI 10.1016/j.eururo.2007.01.027PUB-17280773

Full text at the publisher4 results where Desmopressin was given

Publisher page See results (4)

Randomized controlled trial · 2003

5 results

Efficacy of desmopressin (Minirin) in the treatment of nocturia: a double-blind placebo-controlled study in women.

Lose et al. 2003American journal of obstetrics and gynecologyn = 144cited by 96

PMID 14586363DOI 10.1067/s0002-9378(03)00593-3PUB-14586363

Full text at the publisher5 results where Desmopressin was given

Publisher page See results (5)

More studies

954 studies in all, 17 on this page

PubMed tag: Randomized Controlled Trial, Clinical Trial · 1983

Deamino-8-D-arginine vasopressin shortens the bleeding time in uremia.

Mannucci et al. 1983The New England journal of medicinecited by 325

PMID 6401193DOI 10.1056/nejm198301063080102PUB-06401193

Full text at the publisher

Publisher page

PubMed tag: none · 1982

Multimeric composition of factor VIII/von Willebrand factor following administration of DDAVP: implications for pathophysiology and therapy of von Willebrand's disease subtypes.

Ruggeri et al. 1982Bloodcited by 179

PMID 6805532DOI 10.1182/blood.v59.6.1272.1272PUB-06805532

Full text at the publisher

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PubMed tag: none · 1981

Response of factor VIII/von Willebrand factor to DDAVP in healthy subjects and patients with haemophilia A and von Willebrand's disease.

Mannucci et al. 1981British journal of haematologycited by 177

PMID 6781527DOI 10.1111/j.1365-2141.1981.tb02789.xPUB-06781527

Full text at the publisher

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Indexing hint: In vitro study · 1983

Platelet aggregation induced by 1-desamino-8-D-arginine vasopressin (DDAVP) in Type IIB von Willebrand's disease.

Holmberg et al. 1983The New England journal of medicinecited by 159

PMID 6412139DOI 10.1056/nejm198310063091402PUB-06412139

Full text at the publisher

Publisher page

PubMed tag: Clinical Trial, Multicenter Study · 2008

Response to desmopressin is influenced by the genotype and phenotype in type 1 von Willebrand disease (VWD): results from the European Study MCMDM-1VWD.

Castaman et al. 2008Bloodcited by 138

PMID 18230755DOI 10.1182/blood-2007-08-109231PUB-18230755

Rights unknown

Source link

PubMed tag: Clinical Trial, Multicenter Study · 2004

Biologic response to desmopressin in patients with severe type 1 and type 2 von Willebrand disease: results of a multicenter European study.

Federici et al. 2004Bloodcited by 136

PMID 14630825DOI 10.1182/blood-2003-06-2072PUB-14630825

Full text at the publisher

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PubMed tag: none · 1996

Quantitative analysis of von Willebrand factor propeptide release in vivo: effect of experimental endotoxemia and administration of 1-deamino-8-D-arginine vasopressin in humans.

Borchiellini et al. 1996Bloodcited by 130

PMID 8874191DOI 10.1182/blood.v88.8.2951.bloodjournal8882951PUB-08874191

Full text at the publisher

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PubMed tag: none · 1984

Shortening of bleeding time by 1-deamino-8-D-arginine vasopressin in various bleeding disorders.

Kobrinsky et al. 1984Lancet (London, England)cited by 123

PMID 6144876DOI 10.1016/s0140-6736(84)91393-xPUB-06144876

Full text at the publisher

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PubMed tag: none · 1992

Patterns of development of tachyphylaxis in patients with haemophilia and von Willebrand disease after repeated doses of desmopressin (DDAVP).

Mannucci et al. 1992British journal of haematologycited by 115

PMID 1419807DOI 10.1111/j.1365-2141.1992.tb04598.xPUB-01419807

Full text at the publisher

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PubMed tag: none · 2008

DDAVP is effective in preventing and reversing inadvertent overcorrection of hyponatremia.

Perianayagam et al. 2008Clinical journal of the American Society of Nephrology : CJASNcited by 114

PMID 18235152PMC2390955DOI 10.2215/cjn.03190807PUB-18235152

Rights unknown

Source link

PubMed tag: Controlled Clinical Trial, Clinical Trial · 1986

The effect of desmopressin on nocturnal polyuria, overnight weight loss, and morning postural hypotension in patients with autonomic failure.

Mathias et al. 1986British medical journal (Clinical research ed.)cited by 102

PMID 3089519PMC1341045DOI 10.1136/bmj.293.6543.353PUB-03089519

Rights unknown

Source link

PubMed tag: none · 2013

Hypertonic saline and desmopressin: a simple strategy for safe correction of severe hyponatremia.

Sood et al. 2013American journal of kidney diseases : the official journal of the National Kidney Foundationcited by 99

PMID 23266328DOI 10.1053/j.ajkd.2012.11.032PUB-23266328

Full text at the publisher

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PubMed tag: none · 1985

Response of patients with mild and moderate hemophilia A and von Willebrand's disease to treatment with desmopressin.

de la Fuente et al. 1985Annals of internal medicinecited by 98

PMID 3923887DOI 10.7326/0003-4819-103-1-6PUB-03923887

Full text at the publisher

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PubMed tag: Comparative Study · 1993

Pharmacokinetics of 1-deamino-8-D-arginine vasopressin after various routes of administration in healthy volunteers.

Fjellestad-Paulsen et al. 1993Clinical endocrinologycited by 97

PMID 8435898DOI 10.1111/j.1365-2265.1993.tb00990.xPUB-08435898

Full text at the publisher

Publisher page

PubMed tag: Controlled Clinical Trial, Clinical Trial, Phase III · 2011

Gender difference in antidiuretic response to desmopressin.

Juul et al. 2011American journal of physiology. Renal physiologycited by 97

PMID 21367921DOI 10.1152/ajprenal.00741.2010PUB-21367921

Rights unknown

Source link

PubMed tag: Case Reports · 1989

Hyponatremia and seizures in young children given DDAVP.

Smith et al. 1989American journal of hematologycited by 95

PMID 2500851DOI 10.1002/ajh.2830310310PUB-02500851

Full text at the publisher

Publisher page

PubMed tag: none · 2014

The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT platelets in patients with primary platelet function defects.

Colucci et al. 2014Bloodcited by 88

PMID 24443440DOI 10.1182/blood-2013-04-497123PUB-24443440

Full text at the publisher

Publisher page

Newer studies

PepBank reads each paper before it shows the results. This search looks in Europe PMC for newer papers that PepBank has not read yet.

Desmopressin studies: 138 papers with results

Page 1 of 3

Efficacy and safety of low dose desmopressin orally disintegrating tablet in men with nocturia: results of a multicenter, randomized, double-blind, placebo controlled, parallel group study.
Weiss JP · The Journal of urology · 2013
Randomized controlled trial · 11 results
Efficacy and safety of low dose desmopressin orally disintegrating tablet in women with nocturia: results of a multicenter, randomized, double-blind, placebo controlled, parallel group study.
Sand PK · The Journal of urology · 2013
Randomized controlled trial · 8 results
Desmopressin acetate in percutaneous ultrasound-guided kidney biopsy: a randomized controlled trial.
Manno C · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2011
Randomized controlled trial · 4 results
Gender difference in efficacy and dose response in Japanese patients with nocturia treated with four different doses of desmopressin orally disintegrating tablet in a randomized, placebo-controlled trial.
Yamaguchi O · BJU international · 2013
Randomized controlled trial · 13 results
Low-dose Desmopressin and Tolterodine Combination Therapy for Treating Nocturia in Women with Overactive Bladder: A Double-blind, Randomized, Controlled Study.
Rovner ES · Lower urinary tract symptoms · 2018
Randomized controlled trial · 8 results
DDAVP nasal spray for treatment of menorrhagia in women with inherited bleeding disorders: a randomized placebo-controlled crossover study.
Kadir RA · Haemophilia : the official journal of the World Federation of Hemophilia · 2002
Randomized controlled trial · 1 result
Desmopressin, as a "designer-drug," in the treatment of overactive bladder syndrome.
Hashim H · Neurourology and urodynamics · 2009
Randomized controlled trial · 6 results
Efficacy and safety of 25 and 50 μg desmopressin orally disintegrating tablets in Japanese patients with nocturia due to nocturnal polyuria: Results from two phase 3 studies of a multicenter randomized double-blind placebo-controlled parallel-group development program.
Yamaguchi O · Lower urinary tract symptoms · 2020
Randomized controlled trial · 8 results
Oral desmopressin lyophilisate (MELT) for monosymptomatic enuresis: structured versus abrupt withdrawal.
Ferrara P · Journal of pediatric urology · 2014
Randomized controlled trial · 1 result
Desmopressin orally disintegrating tablet effectively reduces nocturia: results of a randomized, double-blind, placebo-controlled trial.
Weiss JP · Neurourology and urodynamics · 2012
Randomized controlled trial · 8 results
Randomized comparison of long-term desmopressin and alarm treatment for bedwetting.
Evans J · Journal of pediatric urology · 2011
Randomized controlled trial · 5 results
A controlled trial of desmopressin and behavioral therapy for nocturnal enuresis.
Kahan E · Medicine · 1998
Randomized controlled trial · 5 results
A randomised comparison of oral desmopressin lyophilisate (MELT) and tablet formulations in children and adolescents with primary nocturnal enuresis.
Lottmann H · International journal of clinical practice · 2007
Randomized controlled trial · 7 results
Desmopressin melt improves response and compliance compared with tablet in treatment of primary monosymptomatic nocturnal enuresis.
Juul KV · European journal of pediatrics · 2013
Randomized controlled trial · 5 results
Desmopressin and oxybutynin in monosymptomatic nocturnal enuresis: a randomized, double-blind, placebo-controlled trial and an assessment of predictive factors.
Montaldo P · BJU international · 2012
Randomized controlled trial · 1 result
The efficacy and safety of oral desmopressin in children with primary nocturnal enuresis.
Schulman SL · The Journal of urology · 2001
Randomized controlled trial · 6 results
Efficacy of desmopressin in the treatment of nocturia: a double-blind placebo-controlled study in men.
Mattiasson A · BJU international · 2002
Randomized controlled trial · 8 results
A trial of desmopressin (1-desamino-8-D-arginine vasopressin) to reduce blood loss in uncomplicated cardiac surgery.
Hackmann T · The New England journal of medicine · 1989
Randomized controlled trial · 2 results
Efficacy of desmopressin (Minirin) in the treatment of nocturia: a double-blind placebo-controlled study in women.
Lose G · American journal of obstetrics and gynecology · 2003
Randomized controlled trial · 5 results
Comparison of long-term efficacy of desmopressin lyophilisate and enuretic alarm for monosymptomatic enuresis and assessment of predictive factors for success: a randomized prospective trial.
Önol FF · The Journal of urology · 2015
Randomized controlled trial · 5 results
Desmopressin in the treatment of nocturia: a double-blind, placebo-controlled study.
van Kerrebroeck P · European urology · 2007
Randomized controlled trial · 4 results
Use of point-of-care test in identification of patients who can benefit from desmopressin during cardiac surgery: a randomised controlled trial.
Despotis GJ · Lancet (London, England) · 1999
Randomized controlled trial · 8 results
Efficacy of desmopressin and enuresis alarm as first and second line treatment for primary monosymptomatic nocturnal enuresis: prospective randomized crossover study.
Kwak KW · The Journal of urology · 2010
Randomized controlled trial · 5 results
Does desmopressin acetate reduce blood loss after surgery in patients on cardiopulmonary bypass?
Rocha E · Circulation · 1988
Randomized controlled trial · 6 results
Prophylactic treatment with desmopressin does not reduce postoperative bleeding after coronary surgery in patients treated with aspirin before surgery.
Pleym H · Anesthesia and analgesia · 2004
Randomized controlled trial · 1 result
Desmopressin does not decrease bleeding after cardiac operation in young children.
Reynolds LM · The Journal of thoracic and cardiovascular surgery · 1993
Randomized controlled trial · 3 results
Efficacy of desmopressin combined with alarm therapy for monosymptomatic nocturnal enuresis.
Leebeek-Groenewegen A · The Journal of urology · 2001
Randomized controlled trial · 3 results
The hemostatic effects of desmopressin on patients who had total joint arthroplasty. A double-blind randomized trial.
Karnezis TA · The Journal of bone and joint surgery. American volume · 1994
Randomized controlled trial · 5 results
Desmopressin has no beneficial effect on excessive postoperative bleeding or blood product requirements associated with cardiopulmonary bypass.
de Prost D · Thrombosis and haemostasis · 1992
Randomized controlled trial · 6 results
Does desmopressin improve hemostasis and reduce blood loss from aortic surgery? A randomized, double-blind study.
Clagett GP · Journal of vascular surgery · 1995
Randomized controlled trial · 3 results
A new fast-melting oral formulation of desmopressin: a pharmacodynamic study in children with primary nocturnal enuresis.
Vande Walle JG · BJU international · 2006
Randomized controlled trial · 5 results
Desmopressin acetate does not reduce blood loss during total hip replacement in patients receiving dextran.
Schött U · Acta anaesthesiologica Scandinavica · 1995
Randomized controlled trial · 5 results
Comparing alarms, desmopressin, and combined treatment in Chinese enuretic children.
Fai-Ngo Ng C · Pediatric nephrology (Berlin, Germany) · 2005
Randomized controlled trial · 11 results
Treatment with desmopressin acetate to reduce blood loss after cardiac surgery. A double-blind randomized trial.
Salzman EW · The New England journal of medicine · 1986
Randomized controlled trial · 4 results
Nocturnal enuresis and daytime wetting: a multicentric trial with oxybutynin and desmopressin.
Caione P · European urology · 1997
Randomized controlled trial · 3 results
The effect of desmopressin acetate on postoperative hemorrhage in patients receiving aspirin therapy before coronary artery bypass operations.
Gratz I · The Journal of thoracic and cardiovascular surgery · 1992
Randomized controlled trial · 5 results
Desmopressin acetate in uncomplicated coronary artery bypass surgery: a prospective randomized clinical trial.
Hedderich GS · Canadian journal of surgery. Journal canadien de chirurgie · 1990
Randomized controlled trial · 3 results
The effect of desmopressin acetate (DDAVP) on postoperative blood loss after cardiac operations in children.
Seear MD · The Journal of thoracic and cardiovascular surgery · 1989
Randomized controlled trial · 2 results
Desmopressin does not decrease blood loss and transfusion requirements in patients undergoing hepatectomy.
Wong AY · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2003
Randomized controlled trial · 5 results
Randomized study of aprotinin and DDAVP to reduce postoperative bleeding after cardiopulmonary bypass surgery.
Rocha E · Circulation · 1994
Randomized controlled trial · 12 results
Desmopressin for patients with spontaneous intracerebral haemorrhage taking antiplatelet drugs (DASH): a UK-based, phase 2, randomised, placebo-controlled, multicentre feasibility trial.
Desborough MJR · The Lancet. Neurology · 2023
Randomized controlled trial · 4 results
Desmopressin in nocturnal enuresis.
Terho P · The Journal of urology · 1991
Randomized controlled trial · 11 results
Effects of desmopressin on blood loss in hip arthroplasty. Controlled study in 50 patients.
Flordal PA · Acta orthopaedica Scandinavica · 1992
Randomized controlled trial · 3 results
Comparison of desmopressin and enuresis alarm for nocturnal enuresis.
Wille S · Archives of disease in childhood · 1986
Randomized controlled trial · 4 results
Randomized controlled trial of desmopressin plus terlipressin vs. terlipressin alone for the treatment of acute variceal hemorrhage in cirrhotic patients: a multicenter, double-blind study. New Italian Endoscopic Club.
de Franchis R · Hepatology (Baltimore, Md.) · 1993
Randomized controlled trial · 1 result
Use of desmopressin acetate to reduce blood transfusion requirements during cardiac surgery in patients with acetylsalicylic-acid-induced platelet dysfunction.
Sheridan DP · Canadian journal of surgery. Journal canadien de chirurgie · 1994
Randomized controlled trial · 3 results
Influence of desmopressin acetate on homologous blood requirements in cardiac surgical patients pretreated with aspirin.
Dilthey G · Journal of cardiothoracic and vascular anesthesia · 1993
Randomized controlled trial · 4 results
1-Desamino-8-D-arginine vasopressin (desmopressin) decreases operative blood loss in patients having Harrington rod spinal fusion surgery. A randomized, double-blinded, controlled trial.
Kobrinsky NL · Annals of internal medicine · 1987
Randomized controlled trial · 11 results
Desmopressin resistant enuresis: pathogenetic and therapeutic considerations.
Nevéus T · The Journal of urology · 1999
Randomized controlled trial · 3 results
Desmopressin acutely decreases tachycardia and improves symptoms in the postural tachycardia syndrome.
Coffin ST · Heart rhythm · 2012
Randomized controlled trial · 3 results

Status and safety

Regulatory and safety

Approval and sport status, and the safety outcomes reported in study results. Laws and labels change, so check the regulator for the current status.

Regulatory status by jurisdiction, with date and source
Jurisdiction	Body	Status	As of	Source
US	FDA	DDAVP	27 Oct 2026	dailymed.nlm.nih.gov (opens in a new tab)
EU	EMA	Desmopressin	27 Oct 2026	ema.europa.eu (opens in a new tab)
Sport	WADA	Banned in sport (WADA S5) The list names desmopressin as a diuretic or masking agent prohibited at all times.	2026 List	wada-ama.org (opens in a new tab)

Safety outcomes

86 safety results for Desmopressin.

Human evidence· 81

In men with nocturia, adverse events affected similar numbers: 15 (17%) with desmopressin and 16 (25%) with placebo.
Randomized controlled trialn = 151
Adverse events
15 patients
desmopressin
Adverse events
17%
desmopressin
Adverse events
16 patients
placebo
1 more measurement in the study.
In women with overactive bladder, safety profiles were comparable with added desmopressin and tolterodine alone.
Randomized controlled trialn = 106
In elective aortic operation patients, major thromboembolic complication incidence was similar with DDAVP and placebo.
Randomized controlled trialn = 91
In aspirin-pretreated coronary bypass patients, thrombotic complications did not differ between desmopressin and placebo.
Randomized controlled trialn = 65
In intracerebral haemorrhage patients, serious adverse events occurred in 12 participants receiving desmopressin versus 13 receiving placebo.
Randomized controlled trialn = 54
Serious adverse events
44%
desmopressin
Serious adverse events
48%
placebo
In elective CABG, no manifestations of hypercoagulability occurred with DDAVP or placebo.
Randomized controlled trialn = 20
In men with nocturia, serum sodium below 130 mmol/L occurred in 2 subjects on 50 μg versus 9 on 75 μg.
Randomized controlled trialn not reported
Subjects with serum sodium <130 mmol/L
2 subjects
50 μg desmopressin
Subjects with serum sodium <130 mmol/L
9 subjects
75 μg desmopressin
In severe leptospirosis with pulmonary involvement, eight desmopressin recipients died versus three controls, without a significant mortality difference.
Randomized controlled trialn not reported
Deaths, all three groups
15 patients
intention-to-treat
Deaths, all three groups
22%
intention-to-treat
Deaths
8 patients
desmopressin group
3 more measurements in the study.

The top 24 of 81 results.

Doses studied · 119

The doses that these studies used. They are not recommendations.

25 μg once dailyHuman
Species
human
Route
oral
Duration
3 months
Design
Randomized controlled trial · n = 261
0.3 μg/kgHuman
Species
human
Route
subcutaneous
Duration
Not reported
Design
Randomized controlled trial · n = 162
50 μgHuman
Species
human
Route
oral
Duration
3 months
Design
Randomized controlled trial
75 μgHuman
Species
human
Route
oral
Duration
3 months
Design
Randomized controlled trial
300 micro gHuman
Species
human
Route
nasal spray
Duration
2 months
Design
Randomized controlled trial
25 μgHuman
Species
human
Route
oral
Duration
28 days
Design
Randomized controlled trial

Doses studied in the study results, as given in the studies.
Dose as reported	Class	Species	Route	Duration	Design
25 μg once daily	Human	human	oral	3 months	Randomized controlled trial · n = 261
0.3 μg/kg	Human	human	subcutaneous	Not reported	Randomized controlled trial · n = 162
50 μg	Human	human	oral	3 months	Randomized controlled trial
75 μg	Human	human	oral	3 months	Randomized controlled trial
300 micro g	Human	human	nasal spray	2 months	Randomized controlled trial
25 μg	Human	human	oral	28 days	Randomized controlled trial

6 of 119 shown

PepBank is a research reference. Talk to a doctor before you use any peptide.

Data

Data and API

Data version, change history and code for this peptide.

Data version 30856030 Oct 2026

Peptide

Peptide id: PEP-000129
Peptide version: 2
Peptide hash: 40b012e7fa466c3a…
Data version: 308560

Latest changes

28 Oct 2026UpdatedData version 304183
27 Oct 2026CreatedData version 256668

For developers

curl -s https://pepbank.io/v1/briefs/desmopressin

Evidence summary for Desmopressin: counts by class, key results with sources, notices, data version.

Peptide as JSON Evidence summary as JSON

Outcome group	Human	Animal	Lab	Computer model	Total
Bleeding and clottingWhole body	Human: 182 results from 42 studies: 54 increase, 34 decrease, 74 no significant change, 20 not reported. Strongest design: Randomized controlled trial	Animal: 10 results from 3 studies: 3 increase, 5 decrease, 2 no significant change. Strongest design: Animal study (in vivo)	No results	No results	192
Urinary continence and bladder functionKidney and urinary	Human: 96 results from 21 studies: 31 increase, 26 decrease, 9 no significant change, 1 mixed, 29 not reported. Strongest design: Randomized controlled trial	No results	No results	No results	96
Adverse eventsWhole body	Human: 72 results from 38 studies: 5 increase, 6 decrease, 6 no significant change, 55 not reported. Strongest design: Randomized controlled trial	Animal: 1 result from 1 study: 1 not reported. Strongest design: Animal study (in vivo)	No results	No results	73
EnuresisKidney and urinary	Human: 37 results from 12 studies: 9 increase, 8 decrease, 9 no significant change, 11 not reported. Strongest design: Randomized controlled trial	No results	No results	No results	37
Urinary functionKidney and urinary	Human: 22 results from 6 studies: 1 increase, 9 decrease, 10 no significant change, 2 not reported. Strongest design: Randomized controlled trial	No results	No results	No results	22
Urinary ContinenceKidney and urinary	Human: 16 results from 3 studies: 5 increase, 2 decrease, 1 no significant change, 8 not reported. Strongest design: Randomized controlled trial	No results	No results	No results	16
Urine ProductionKidney and urinary	Human: 14 results from 4 studies: 1 increase, 6 decrease, 1 no significant change, 6 not reported. Strongest design: Randomized controlled trial	Animal: 1 result from 1 study: 1 decrease. Strongest design: Animal study (in vivo)	No results	No results	15
Blood LossCardiovascular	Human: 14 results from 6 studies: 4 increase, 3 decrease, 7 no significant change. Strongest design: Randomized controlled trial	No results	No results	No results	14
NocturiaKidney and urinary	Human: 14 results from 5 studies: 5 increase, 7 decrease, 2 not reported. Strongest design: Randomized controlled trial	No results	No results	No results	14
BleedingWhole body	Human: 13 results from 9 studies: 1 increase, 7 decrease, 4 no significant change, 1 not reported. Strongest design: Randomized controlled trial	No results	No results	No results	13
SleepSleep	Human: 13 results from 9 studies: 11 increase, 1 mixed, 1 not reported. Strongest design: Randomized controlled trial	No results	No results	No results	13
Urinary FunctionKidney and urinary	Human: 10 results from 2 studies: 6 decrease, 4 not reported. Strongest design: Non-randomized trial	No results	No results	No results	10

Outcome group	Human	Animal	Lab	Computer model	Total
Bleeding and clottingWhole body	Human: 182 results from 42 studies: 54 increase, 34 decrease, 74 no significant change, 20 not reported. Strongest design: Randomized controlled trial	Animal: 10 results from 3 studies: 3 increase, 5 decrease, 2 no significant change. Strongest design: Animal study (in vivo)	No results	No results	192
Urinary continence and bladder functionKidney and urinary	Human: 96 results from 21 studies: 31 increase, 26 decrease, 9 no significant change, 1 mixed, 29 not reported. Strongest design: Randomized controlled trial	No results	No results	No results	96
Adverse eventsWhole body	Human: 72 results from 38 studies: 5 increase, 6 decrease, 6 no significant change, 55 not reported. Strongest design: Randomized controlled trial	Animal: 1 result from 1 study: 1 not reported. Strongest design: Animal study (in vivo)	No results	No results	73
EnuresisKidney and urinary	Human: 37 results from 12 studies: 9 increase, 8 decrease, 9 no significant change, 11 not reported. Strongest design: Randomized controlled trial	No results	No results	No results	37
Urinary functionKidney and urinary	Human: 22 results from 6 studies: 1 increase, 9 decrease, 10 no significant change, 2 not reported. Strongest design: Randomized controlled trial	No results	No results	No results	22
Urinary ContinenceKidney and urinary	Human: 16 results from 3 studies: 5 increase, 2 decrease, 1 no significant change, 8 not reported. Strongest design: Randomized controlled trial	No results	No results	No results	16
Urine ProductionKidney and urinary	Human: 14 results from 4 studies: 1 increase, 6 decrease, 1 no significant change, 6 not reported. Strongest design: Randomized controlled trial	Animal: 1 result from 1 study: 1 decrease. Strongest design: Animal study (in vivo)	No results	No results	15
Blood LossCardiovascular	Human: 14 results from 6 studies: 4 increase, 3 decrease, 7 no significant change. Strongest design: Randomized controlled trial	No results	No results	No results	14
NocturiaKidney and urinary	Human: 14 results from 5 studies: 5 increase, 7 decrease, 2 not reported. Strongest design: Randomized controlled trial	No results	No results	No results	14
BleedingWhole body	Human: 13 results from 9 studies: 1 increase, 7 decrease, 4 no significant change, 1 not reported. Strongest design: Randomized controlled trial	No results	No results	No results	13
SleepSleep	Human: 13 results from 9 studies: 11 increase, 1 mixed, 1 not reported. Strongest design: Randomized controlled trial	No results	No results	No results	13
Urinary FunctionKidney and urinary	Human: 10 results from 2 studies: 6 decrease, 4 not reported. Strongest design: Non-randomized trial	No results	No results	No results	10