In elective cardiac surgery, median blood loss was similar with desmopressin and placebo (865 versus 738 ml, P = 0.26).
In plain wordsIn elective cardiac surgery, desmopressin and placebo produced similar blood loss.
- Peptide
- Desmopressin
- Outcome
- No significant changeBlood loss within 24 hours
- Study
n = 150
- Comparator
- Saline placebo
- Outcome group
- Bleeding and clotting · Whole body
- Studied dose
- 0.3 microgram per kilogram · intravenousAs given in this study (human).
Measurements
- Median blood loss within 24 hours
- 865 ml
- desmopressin group
- Median blood loss within 24 hours
- 738 ml
- placebo group
- p
- 0.26
- desmopressin versus placebo, blood loss
Source sentences
The median amount of blood lost within the first 24 hours after operation was similar in the desmopressin and placebo groups (865 vs. 738 ml; P = 0.26).
2 context sentences(design, population, supporting numbers)
To pursue this question further, we performed a double-blind, randomized, placebo-controlled trial to determine whether the previously reported beneficial effect of desmopressin on hemostasis during complex cardiac surgery was applicable to all elective cardiac surgical procedures involving cardiopulmonary bypass.
In 150 consecutive patients, most of whom underwent primary coronary-artery bypass grafting, we compared the effects of intravenous desmopressin (0.3 microgram per kilogram of body weight) with those of saline placebo on postoperative blood loss and the need to replace blood products.