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Study · Randomized controlled trial · n = 50 · 1992

3 results

Effects of desmopressin on blood loss in hip arthroplasty. Controlled study in 50 patients.

Flordal PA, Ljungström KG, Ekman B, Neander G

Acta orthopaedica Scandinavica1 Aug 1992Cited by 26 (Europe PMC)

PMID1529684 (opens in a new tab)DOI10.3109/17453679209154749 (opens in a new tab)PepBankPUB-01529684
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In hip replacement patients, intraoperative blood loss did not differ significantly between desmopressin and placebo.

    In plain wordsIn hip replacement patients, intraoperative blood loss did not differ significantly between desmopressin and placebo.

    Peptide
    Desmopressin
    Outcome
    No significant changeIntraoperative blood loss
    Study

    n = 50

    Comparator
    Placebo
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    two doses of 0.3 micrograms/kg BWAs given in this study (human).

    Source sentences

    Summary
    Intraoperative blood loss and drainage loss did not differ significantly between groups, but desmopressin reduced the mean total blood loss (calculated from hemoglobin decrease and blood transfusions) by 310 mL (P less than 0.05).
    1 context sentence
    Summary · context
    50 patients undergoing elective total hip replacement under epidural anesthesia and dextran infusion were given two doses of the vasopressin analogue desmopressin 0.3 micrograms/kg BW or placebo in a double-blinded randomized prospective study.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In hip replacement patients, drainage loss did not differ significantly between desmopressin and placebo.

    In plain wordsIn hip replacement patients, drainage loss did not differ significantly between desmopressin and placebo.

    Peptide
    Desmopressin
    Outcome
    No significant changeDrainage loss
    Study

    n = 50

    Comparator
    Placebo
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    two doses of 0.3 micrograms/kg BWAs given in this study (human).

    Source sentences

    Summary
    Intraoperative blood loss and drainage loss did not differ significantly between groups, but desmopressin reduced the mean total blood loss (calculated from hemoglobin decrease and blood transfusions) by 310 mL (P less than 0.05).
    1 context sentence
    Summary · context
    50 patients undergoing elective total hip replacement under epidural anesthesia and dextran infusion were given two doses of the vasopressin analogue desmopressin 0.3 micrograms/kg BW or placebo in a double-blinded randomized prospective study.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In hip replacement patients, desmopressin reduced calculated total blood loss by 310 mL versus placebo.

    In plain wordsIn hip replacement patients, desmopressin reduced calculated total blood loss by 310 mL versus placebo.

    Peptide
    Desmopressin
    Outcome
    DecreaseCalculated total blood loss
    Study

    n = 50

    Comparator
    Placebo
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    two doses of 0.3 micrograms/kg BWAs given in this study (human).

    Measurements

    Total blood loss reduction
    310 mL
    desmopressin versus placebo
    P
    < 0.05
    between groups

    Source sentences

    Summary
    Intraoperative blood loss and drainage loss did not differ significantly between groups, but desmopressin reduced the mean total blood loss (calculated from hemoglobin decrease and blood transfusions) by 310 mL (P less than 0.05).
    1 context sentence
    Summary · context
    50 patients undergoing elective total hip replacement under epidural anesthesia and dextran infusion were given two doses of the vasopressin analogue desmopressin 0.3 micrograms/kg BW or placebo in a double-blinded randomized prospective study.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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