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Study · Randomized controlled trial · n = 70 · 1986

4 results

Treatment with desmopressin acetate to reduce blood loss after cardiac surgery. A double-blind randomized trial.

Salzman EW, Weinstein MJ, Weintraub RM, Ware JA, Thurer RL, Robertson L, Donovan A, Gaffney T, Bertele V, Troll J

The New England journal of medicine1 May 1986Cited by 275 (Europe PMC)

PMID3517650 (opens in a new tab)DOI10.1056/nejm198605293142202 (opens in a new tab)PepBankPUB-03517650
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In cardiac surgery patients, desmopressin reduced mean operative and early postoperative blood loss to 1317 +/- 486 ml versus 2210 +/- 1415 ml with placebo.

    In plain wordsIn cardiac surgery patients, desmopressin reduced blood loss versus placebo.

    Peptide
    Desmopressin
    Outcome
    DecreaseOperative and early postoperative blood loss
    Study

    n = 70

    Comparator
    Placebo
    Outcome group
    Bleeding and clotting · Whole body
    Studied dose
    Dose not stated

    Measurements

    Mean operative and early postoperative blood loss
    1317 ml
    desmopressin group; +/- 486
    Mean operative and early postoperative blood loss
    2210 ml
    placebo group; +/- 1415

    Source sentences

    Summary
    The drug significantly reduced mean operative and early postoperative blood loss (1317 +/- 486 ml in the treated group vs. 2210 +/- 1415 ml in the placebo group); of the 14 patients whose 24-hour blood loss exceeded 2000 ml, 11 had received the placebo.
    2 context sentences
    Summary · context
    In a double-blind, prospective, randomized trial, we studied the effect of intraoperative desmopressin acetate in 70 patients undergoing various cardiac operations requiring cardiopulmonary bypass.
    Summary · context
    Patients undergoing uncomplicated primary coronary-artery bypass grafting were not included.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In cardiac surgery patients, 11 of the 14 patients whose 24-hour blood loss exceeded 2000 ml had received placebo.

    In plain wordsIn cardiac surgery patients, 11 of the 14 patients who lost over 2000 ml of blood in 24 hours had received placebo.

    Peptide
    Desmopressin
    Outcome
    DecreaseBlood loss exceeding 2000 ml
    Study

    n = 70

    Comparator
    Placebo
    Outcome group
    Bleeding and clotting · Whole body
    Studied dose
    Dose not stated

    Measurements

    Patients with 24-hour blood loss above 2000 ml
    14 patients
    both groups
    Patients with 24-hour blood loss above 2000 ml who received placebo
    11 patients
    of the 14

    Source sentences

    Summary
    The drug significantly reduced mean operative and early postoperative blood loss (1317 +/- 486 ml in the treated group vs. 2210 +/- 1415 ml in the placebo group); of the 14 patients whose 24-hour blood loss exceeded 2000 ml, 11 had received the placebo.
    2 context sentences
    Summary · context
    In a double-blind, prospective, randomized trial, we studied the effect of intraoperative desmopressin acetate in 70 patients undergoing various cardiac operations requiring cardiopulmonary bypass.
    Summary · context
    Patients undergoing uncomplicated primary coronary-artery bypass grafting were not included.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In cardiac surgery patients, plasma von Willebrand factor was higher after desmopressin than placebo.

    In plain wordsIn cardiac surgery patients, desmopressin increased von Willebrand factor versus placebo.

    Peptide
    Desmopressin
    Outcome
    Increasevon Willebrand factor
    Study

    n = 70

    Comparator
    Placebo
    Outcome group
    Bleeding and clotting · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Plasma levels of von Willebrand factor were higher after desmopressin acetate than after placebo.
    2 context sentences
    Summary · context
    In a double-blind, prospective, randomized trial, we studied the effect of intraoperative desmopressin acetate in 70 patients undergoing various cardiac operations requiring cardiopulmonary bypass.
    Summary · context
    Patients undergoing uncomplicated primary coronary-artery bypass grafting were not included.
  4. 04HumanNon-randomized trialSafety outcome

    In cardiac surgery patients, desmopressin produced no untoward side effects.

    In plain wordsIn cardiac surgery patients, desmopressin produced no untoward side effects.

    Peptide
    Desmopressin
    Outcome
    Not applicableUntoward side effects
    Study

    n: not reported in source

    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    There were no untoward side effects of desmopressin acetate.
    2 context sentences
    Summary · context
    In a double-blind, prospective, randomized trial, we studied the effect of intraoperative desmopressin acetate in 70 patients undergoing various cardiac operations requiring cardiopulmonary bypass.
    Summary · context
    Patients undergoing uncomplicated primary coronary-artery bypass grafting were not included.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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