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Study · Non-randomized trial · n = 6 · 1986

15 results

Hormonal and cardiovascular responses to DDAVP in man.

Williams TD, Lightman SL, Leadbeater MJ

Clinical endocrinology1 Jan 1986Cited by 26 (Europe PMC)

PMID3519005 (opens in a new tab)DOI10.1111/j.1365-2265.1986.tb03258.x (opens in a new tab)PepBankPUB-03519005
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. 15 results from people.

  1. 01HumanNon-randomized trialSafety outcome

    In healthy volunteers, facial flushing occurred five minutes after desmopressin injection.

    In plain wordsIn healthy volunteers, facial flushing occurred after desmopressin.

    Peptide
    Desmopressin
    Outcome
    IncreaseFacial flushing
    Study

    n = 6

    Outcome group
    Adverse events · Skin and wound
    Studied dose
    0.4 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Five minutes following the DDAVP injection, facial flushing, a fall in diastolic blood pressure by an average of 13% and a rise in pulse rate by an average of 18% were observed.
    2 context sentences
    Summary · context
    Hormonal and cardiovascular responses to 1-desamino-8-D-arginine vasopressin (DDAVP) were investigated in six normal adult volunteers.
    Summary · context
    After overnight fluid deprivation, an intravenous injection of either DDAVP (0.4 microgram/kg) or the same volume of normal saline was administered.
  2. 02HumanNon-randomized trialActivity measurement

    In healthy volunteers, diastolic pressure fell by an average of 13% five minutes after desmopressin.

    In plain wordsIn healthy volunteers, diastolic blood pressure fell after desmopressin.

    Peptide
    Desmopressin
    Outcome
    DecreaseDiastolic blood pressure
    Study

    n = 6

    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    0.4 microgram/kg · intravenousAs given in this study (human).

    Measurements

    Average fall in diastolic blood pressure
    13%
    five minutes after DDAVP 0.4 microgram/kg

    Source sentences

    Summary
    Five minutes following the DDAVP injection, facial flushing, a fall in diastolic blood pressure by an average of 13% and a rise in pulse rate by an average of 18% were observed.
    2 context sentences
    Summary · context
    Hormonal and cardiovascular responses to 1-desamino-8-D-arginine vasopressin (DDAVP) were investigated in six normal adult volunteers.
    Summary · context
    After overnight fluid deprivation, an intravenous injection of either DDAVP (0.4 microgram/kg) or the same volume of normal saline was administered.
  3. 03HumanNon-randomized trialActivity measurement

    In healthy volunteers, pulse rate rose by an average of 18% five minutes after desmopressin.

    In plain wordsIn healthy volunteers, pulse rate rose after desmopressin.

    Peptide
    Desmopressin
    Outcome
    IncreasePulse rate
    Study

    n = 6

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.4 microgram/kg · intravenousAs given in this study (human).

    Measurements

    Average rise in pulse rate
    18%
    five minutes after DDAVP 0.4 microgram/kg

    Source sentences

    Summary
    Five minutes following the DDAVP injection, facial flushing, a fall in diastolic blood pressure by an average of 13% and a rise in pulse rate by an average of 18% were observed.
    2 context sentences
    Summary · context
    Hormonal and cardiovascular responses to 1-desamino-8-D-arginine vasopressin (DDAVP) were investigated in six normal adult volunteers.
    Summary · context
    After overnight fluid deprivation, an intravenous injection of either DDAVP (0.4 microgram/kg) or the same volume of normal saline was administered.
  4. 04HumanNon-randomized trialActivity measurement

    In healthy volunteers, desmopressin significantly increased plasma renin activity.

    In plain wordsIn healthy volunteers, plasma renin activity increased after desmopressin.

    Peptide
    Desmopressin
    Outcome
    IncreasePlasma renin activity
    Study

    n = 6

    Outcome group
    Renin activity · Endocrine and hormones
    Studied dose
    0.4 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    There was a significant increase in plasma renin activity and plasma cortisol concentration, but no significant changes were observed in plasma concentrations of LH, FSH, TSH, prolactin or GH.
    2 context sentences
    Summary · context
    Hormonal and cardiovascular responses to 1-desamino-8-D-arginine vasopressin (DDAVP) were investigated in six normal adult volunteers.
    Summary · context
    After overnight fluid deprivation, an intravenous injection of either DDAVP (0.4 microgram/kg) or the same volume of normal saline was administered.
  5. 05HumanNon-randomized trialActivity measurement

    In healthy volunteers, desmopressin significantly increased plasma cortisol concentration.

    In plain wordsIn healthy volunteers, cortisol increased after desmopressin.

    Peptide
    Desmopressin
    Outcome
    IncreasePlasma cortisol
    Study

    n = 6

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    0.4 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    There was a significant increase in plasma renin activity and plasma cortisol concentration, but no significant changes were observed in plasma concentrations of LH, FSH, TSH, prolactin or GH.
    2 context sentences
    Summary · context
    Hormonal and cardiovascular responses to 1-desamino-8-D-arginine vasopressin (DDAVP) were investigated in six normal adult volunteers.
    Summary · context
    After overnight fluid deprivation, an intravenous injection of either DDAVP (0.4 microgram/kg) or the same volume of normal saline was administered.
  6. 06HumanNon-randomized trialActivity measurement

    In healthy volunteers, plasma LH did not change significantly after desmopressin.

    In plain wordsIn healthy volunteers, LH did not change significantly after desmopressin.

    Peptide
    Desmopressin
    Outcome
    No significant changeLH
    Study

    n = 6

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.4 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    There was a significant increase in plasma renin activity and plasma cortisol concentration, but no significant changes were observed in plasma concentrations of LH, FSH, TSH, prolactin or GH.
    2 context sentences
    Summary · context
    Hormonal and cardiovascular responses to 1-desamino-8-D-arginine vasopressin (DDAVP) were investigated in six normal adult volunteers.
    Summary · context
    After overnight fluid deprivation, an intravenous injection of either DDAVP (0.4 microgram/kg) or the same volume of normal saline was administered.
  7. 07HumanNon-randomized trialActivity measurement

    In healthy volunteers, plasma FSH did not change significantly after desmopressin.

    In plain wordsIn healthy volunteers, FSH did not change significantly after desmopressin.

    Peptide
    Desmopressin
    Outcome
    No significant changeFSH
    Study

    n = 6

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.4 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    There was a significant increase in plasma renin activity and plasma cortisol concentration, but no significant changes were observed in plasma concentrations of LH, FSH, TSH, prolactin or GH.
    2 context sentences
    Summary · context
    Hormonal and cardiovascular responses to 1-desamino-8-D-arginine vasopressin (DDAVP) were investigated in six normal adult volunteers.
    Summary · context
    After overnight fluid deprivation, an intravenous injection of either DDAVP (0.4 microgram/kg) or the same volume of normal saline was administered.
  8. 08HumanNon-randomized trialActivity measurement

    In healthy volunteers, plasma TSH did not change significantly after desmopressin.

    In plain wordsIn healthy volunteers, TSH did not change significantly after desmopressin.

    Peptide
    Desmopressin
    Outcome
    No significant changeTSH
    Study

    n = 6

    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    0.4 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    There was a significant increase in plasma renin activity and plasma cortisol concentration, but no significant changes were observed in plasma concentrations of LH, FSH, TSH, prolactin or GH.
    2 context sentences
    Summary · context
    Hormonal and cardiovascular responses to 1-desamino-8-D-arginine vasopressin (DDAVP) were investigated in six normal adult volunteers.
    Summary · context
    After overnight fluid deprivation, an intravenous injection of either DDAVP (0.4 microgram/kg) or the same volume of normal saline was administered.
  9. 09HumanNon-randomized trialActivity measurement

    In healthy volunteers, plasma prolactin did not change significantly after desmopressin.

    In plain wordsIn healthy volunteers, prolactin did not change significantly after desmopressin.

    Peptide
    Desmopressin
    Outcome
    No significant changeProlactin
    Study

    n = 6

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.4 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    There was a significant increase in plasma renin activity and plasma cortisol concentration, but no significant changes were observed in plasma concentrations of LH, FSH, TSH, prolactin or GH.
    2 context sentences
    Summary · context
    Hormonal and cardiovascular responses to 1-desamino-8-D-arginine vasopressin (DDAVP) were investigated in six normal adult volunteers.
    Summary · context
    After overnight fluid deprivation, an intravenous injection of either DDAVP (0.4 microgram/kg) or the same volume of normal saline was administered.
  10. 10HumanNon-randomized trialActivity measurement

    In healthy volunteers, plasma GH did not change significantly after desmopressin.

    In plain wordsIn healthy volunteers, GH did not change significantly after desmopressin.

    Peptide
    Desmopressin
    Outcome
    No significant changeGH
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.4 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    There was a significant increase in plasma renin activity and plasma cortisol concentration, but no significant changes were observed in plasma concentrations of LH, FSH, TSH, prolactin or GH.
    2 context sentences
    Summary · context
    Hormonal and cardiovascular responses to 1-desamino-8-D-arginine vasopressin (DDAVP) were investigated in six normal adult volunteers.
    Summary · context
    After overnight fluid deprivation, an intravenous injection of either DDAVP (0.4 microgram/kg) or the same volume of normal saline was administered.
  11. 11HumanNon-randomized trialActivity measurement

    In healthy volunteers, AVP rose equally after hypertonic saline in desmopressin and control studies.

    In plain wordsIn healthy volunteers, AVP responses to hypertonic saline were similar with desmopressin and control treatment.

    Peptide
    Desmopressin
    Outcome
    Direction not reportedAVP response to osmotic stimulation
    Study

    n = 6

    Comparator
    Normal saline
    Outcome group
    Vasopressin response · Endocrine and hormones
    Studied dose
    0.4 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Following osmotic stimulation by hypertonic saline plasma AVP rose to the same extent in both the DDAVP and control studies.
    2 context sentences
    Summary · context
    Hormonal and cardiovascular responses to 1-desamino-8-D-arginine vasopressin (DDAVP) were investigated in six normal adult volunteers.
    Summary · context
    After overnight fluid deprivation, an intravenous injection of either DDAVP (0.4 microgram/kg) or the same volume of normal saline was administered.
  12. 12HumanNon-randomized trialSafety outcome

    In subjects with cranial diabetes insipidus, facial flushing occurred after desmopressin.

    In plain wordsIn subjects with cranial diabetes insipidus, facial flushing occurred after desmopressin.

    Peptide
    Desmopressin
    Outcome
    IncreaseFacial flushing in cranial diabetes insipidus
    Study

    n = 5

    Outcome group
    Adverse events · Skin and wound
    Studied dose
    0.4 microgram/kgAs given in this study (human).

    Source sentences

    Summary
    Again facial flushing, increased facial temperature, a fall in diastolic pressure and a rise in heart rate were all observed, suggesting that DDAVP exerts its cardiovascular actions by a mechanism other than antagonism of circulating endogenous AVP.
    1 context sentence
    Summary · context
    DDAVP (0.4 microgram/kg) was also administered to five subjects with cranial diabetes insipidus.
  13. 13HumanNon-randomized trialActivity measurement

    In subjects with cranial diabetes insipidus, facial temperature increased after desmopressin.

    In plain wordsIn subjects with cranial diabetes insipidus, facial temperature increased after desmopressin.

    Peptide
    Desmopressin
    Outcome
    IncreaseFacial temperature in cranial diabetes insipidus
    Study

    n = 5

    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    0.4 microgram/kgAs given in this study (human).

    Source sentences

    Summary
    Again facial flushing, increased facial temperature, a fall in diastolic pressure and a rise in heart rate were all observed, suggesting that DDAVP exerts its cardiovascular actions by a mechanism other than antagonism of circulating endogenous AVP.
    1 context sentence
    Summary · context
    DDAVP (0.4 microgram/kg) was also administered to five subjects with cranial diabetes insipidus.
  14. 14HumanNon-randomized trialActivity measurement

    In subjects with cranial diabetes insipidus, diastolic pressure fell after desmopressin.

    In plain wordsIn subjects with cranial diabetes insipidus, diastolic pressure fell after desmopressin.

    Peptide
    Desmopressin
    Outcome
    DecreaseDiastolic pressure in cranial diabetes insipidus
    Study

    n = 5

    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    0.4 microgram/kgAs given in this study (human).

    Source sentences

    Summary
    Again facial flushing, increased facial temperature, a fall in diastolic pressure and a rise in heart rate were all observed, suggesting that DDAVP exerts its cardiovascular actions by a mechanism other than antagonism of circulating endogenous AVP.
    1 context sentence
    Summary · context
    DDAVP (0.4 microgram/kg) was also administered to five subjects with cranial diabetes insipidus.
  15. 15HumanNon-randomized trialActivity measurement

    In subjects with cranial diabetes insipidus, heart rate increased after desmopressin.

    In plain wordsIn subjects with cranial diabetes insipidus, heart rate increased after desmopressin.

    Peptide
    Desmopressin
    Outcome
    IncreaseHeart rate in cranial diabetes insipidus
    Study

    n = 5

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.4 microgram/kgAs given in this study (human).

    Source sentences

    Summary
    Again facial flushing, increased facial temperature, a fall in diastolic pressure and a rise in heart rate were all observed, suggesting that DDAVP exerts its cardiovascular actions by a mechanism other than antagonism of circulating endogenous AVP.
    1 context sentence
    Summary · context
    DDAVP (0.4 microgram/kg) was also administered to five subjects with cranial diabetes insipidus.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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