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Trial · Interventional

CompletedPhase 4Registry data

Desmopressin in Cardiac Surgery

NCTNCT00337766 (opens ClinicalTrials.gov in a new tab)Other idDS/URC/ER/mm 151/DG
Open at ClinicalTrials.govAsk about this trial

Overview

Status
Completed
Phase
Phase 4
Enrollment
Not stated
Sponsor
Università Vita-Salute San Raffaele · Other
Design
Randomized · Quadruple masking
Countries
1 country

Italy

Start
Jun 2006
Primary completion
Sept 2009
Completion
Sept 2010
First posted
16 Jun 2006 (estimated)
Last update posted
21 Oct 2015 (estimated)
Conditions
Hemorrhage · Blood Loss, Surgical · Postoperative Hemorrhage

Timeline

1 trial · 1 completed

  • Completed
  • Ongoing
  • Not yet recruiting
  • Stopped
  • Estimated dates (est.)
  • Results posted
200620072008200920102011
  1. Ph 4

    Desmopressin in Cardiac Surgery

    NCT00337766

    Jun 2006 to Sept 2010

Registry summary

Text and fields below are the sponsor's entries at ClinicalTrials.gov, shown as posted.

Patients undergoing cardiac surgery could develop excessive perioperative bleeding requiring transfusions of blood products. Desmopressin (DDAVP), already used for patients with von Willebrand syndrome, could reduce bleeding and transfusion requirements in these patients when administered ev (0.3 mg/kg) in 20-30 minutes postoperatively.

Interventions

  • Desmopressin (DDAVP)Drug
  • PlaceboDrug

Arms2

  • Active comparator

    Desmopressin (DDAVP)

  • Placebo comparator

    Placebo

Primary outcomes1

Outcomes the sponsor listed as primary.

  1. Reduce transfusions

Secondary outcomes(4)

  1. Reduced bleeding

  2. Reduce time on mechanical ventilation

  3. Reduced ICU and Hospital stay

  4. Reduced mortality

Posted results

Values are shown as posted at ClinicalTrials.gov, with their units. PepBank has not converted, pooled or compared them.

No results are posted for this trial.

Completed trials do not always post results.

Registry data comes from ClinicalTrials.gov. Study results come from studies, not from the registry. How PepBank works

Studies1

Studies that cite this trial.

More studies

1 study on this page

Indexing hint: Meta-analysis (pooled) · 2008

Desmopressin reduces transfusion needs after surgery: a meta-analysis of randomized clinical trials.

Crescenzi et al. 2008Anesthesiologycited by 86

PMID 19034103DOI 10.1097/aln.0b013e31818db18bPUB-19034103

Full text at the publisher
Publisher page

Eligibility

Who could join, as posted.

Sex
All
Age
from 18 Years up to 100 Years
Healthy volunteers
Not accepted
Inclusion and exclusion criteria, as posted
Inclusion Criteria: * undergoing cardiac surgery * excessive bleeding Exclusion Criteria: * age\<18 y * not signing written consent

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