In children after cardiac surgery, blood loss did not differ significantly: 40.0 +/- 33.1 ml/kg with desmopressin versus 30.5 +/- 37.9 with placebo.
In plain wordsIn children after cardiac surgery, desmopressin did not significantly change blood loss compared with placebo.
- Peptide
- Desmopressin
- Outcome
- No significant changePostoperative blood loss
- Study
n = 60
- Comparator
- Saline placebo
- Outcome group
- Bleeding and clotting · Whole body
- Studied dose
- 0.3 microgram/kg · intravenousAs given in this study (human).
Measurements
- Postoperative blood loss
- 40 ml/kg
- desmopressin group, +/- 33.1
- Postoperative blood loss
- 30.5 ml/kg
- placebo group, +/- 37.9
Source sentences
Results showed no significant difference in postoperative blood loss between the two groups (30.5 +/- 37.9 ml/kg in the placebo group versus 40.0 +/- 33.1 ml/kg in the desmopressin group).
2 context sentences(design, population, supporting numbers)
We investigated the effect of an intraoperative desmopressin acetate infusion on blood loss after cardiac operation in 60 children, by using a prospective, randomized, double-blind trial.
Thirty patients received a desmopressin dose of 0.3 microgram/kg intravenously over 15 minutes at the conclusion of cardiac bypass, and 30 received a saline placebo.