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Study · Randomized controlled trial · n = 142 · 2015

5 results

Comparison of long-term efficacy of desmopressin lyophilisate and enuretic alarm for monosymptomatic enuresis and assessment of predictive factors for success: a randomized prospective trial.

Önol FF, Guzel R, Tahra A, Kaya C, Boylu U

The Journal of urology23 Aug 2014Cited by 27 (Europe PMC)

PMID25158273 (opens in a new tab)DOI10.1016/j.juro.2014.08.088 (opens in a new tab)PepBankPUB-25158273
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialOther

    In children with monosymptomatic enuresis, four desmopressin recipients withdrew versus 20 alarm recipients after randomization.

    In plain wordsIn children with bedwetting, withdrawal occurred in 5.2% with desmopressin versus 30.7% with an alarm.

    Peptide
    Desmopressin
    Outcome
    DecreaseWithdrawal after randomization
    Study

    n = 142

    Comparator
    enuretic alarm
    Outcome group
    Treatment adherence and retention · Kidney and urinary
    Studied dose
    Dose not stated · sublingual · 6 monthsAs given in this study (human).

    Measurements

    Withdrawals
    4 children
    desmopressin
    Withdrawal proportion
    5.2%
    desmopressin
    Withdrawals
    20 children
    alarm
    Withdrawal proportion
    30.7%
    alarm

    Source sentences

    Summary
    Overall 4 children (5.2%) in the desmopressin group and 20 (30.7%) in the enuretic alarm group withdrew after randomization.
    3 context sentences
    Summary · context
    We compared the long-term success of desmopressin sublingual lyophilisate formulation and enuretic alarm therapy in children with primary monosymptomatic nocturnal enuresis, and determined predictive factors for treatment success.
    Summary · context
    A total of 142 children with primary monosymptomatic nocturnal enuresis were randomized to receive treatment consisting of desmopressin or enuretic alarm for 6 months.
    Summary · context
    Additional intention to treat analyses were performed, considering cases with missing data as failures.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In children with enuresis, intention-to-treat long-term success was significantly higher with desmopressin than an alarm, 68.8% versus 46.2%.

    In plain wordsIn children with bedwetting, long-term success including missing cases was higher with desmopressin than an alarm.

    Peptide
    Desmopressin
    Outcome
    IncreaseLong-term success in intention-to-treat population
    Study

    n = 142

    Comparator
    enuretic alarm
    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    Dose not stated · sublingual · 6 monthsAs given in this study (human).

    Measurements

    Long-term success
    68.8%
    desmopressin
    Long-term success
    46.2%
    alarm

    Source sentences

    Summary
    However, long-term success rate was significantly higher with desmopressin (68.8% vs 46.2%) if intention to treat population was considered.
    3 context sentences
    Summary · context
    We compared the long-term success of desmopressin sublingual lyophilisate formulation and enuretic alarm therapy in children with primary monosymptomatic nocturnal enuresis, and determined predictive factors for treatment success.
    Summary · context
    A total of 142 children with primary monosymptomatic nocturnal enuresis were randomized to receive treatment consisting of desmopressin or enuretic alarm for 6 months.
    Summary · context
    Additional intention to treat analyses were performed, considering cases with missing data as failures.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In children completing treatment, success occurred in 76.8% with desmopressin versus 61.8% with an alarm at 6 months.

    In plain wordsIn children completing treatment, desmopressin achieved bedwetting success in 76.8% versus 61.8% with an alarm.

    Peptide
    Desmopressin
    Outcome
    IncreaseSuccess at 6 months in completers
    Study

    n: not reported in source

    Comparator
    enuretic alarm
    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    Dose not stated · sublingual · 6 monthsAs given in this study (human).

    Measurements

    Success
    76.8%
    desmopressin
    Success
    61.8%
    alarm

    Source sentences

    Summary
    Based on patients who completed 6 months of treatment, success (more than 90% reduction in wet nights per month) was achieved in 76.8% and 61.8% of children in the desmopressin and enuretic alarm groups, respectively.
    3 context sentences
    Summary · context
    We compared the long-term success of desmopressin sublingual lyophilisate formulation and enuretic alarm therapy in children with primary monosymptomatic nocturnal enuresis, and determined predictive factors for treatment success.
    Summary · context
    A total of 142 children with primary monosymptomatic nocturnal enuresis were randomized to receive treatment consisting of desmopressin or enuretic alarm for 6 months.
    Summary · context
    Additional intention to treat analyses were performed, considering cases with missing data as failures.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In children with monosymptomatic enuresis, success at 12 months occurred in 77.8% receiving desmopressin versus 75% receiving an alarm.

    In plain wordsIn children with bedwetting, success at 12 months occurred in 77.8% with desmopressin versus 75% with an alarm.

    Peptide
    Desmopressin
    Outcome
    IncreaseSuccess at 12 months
    Study

    n: not reported in source

    Comparator
    enuretic alarm
    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    Dose not stated · sublingual · 6 monthsAs given in this study (human).

    Measurements

    Success
    77.8%
    desmopressin
    Success
    75%
    alarm

    Source sentences

    Summary
    At 12 months 77.8% of those receiving desmopressin and 75% of those treated with enuretic alarm had success.
    3 context sentences
    Summary · context
    We compared the long-term success of desmopressin sublingual lyophilisate formulation and enuretic alarm therapy in children with primary monosymptomatic nocturnal enuresis, and determined predictive factors for treatment success.
    Summary · context
    A total of 142 children with primary monosymptomatic nocturnal enuresis were randomized to receive treatment consisting of desmopressin or enuretic alarm for 6 months.
    Summary · context
    Additional intention to treat analyses were performed, considering cases with missing data as failures.
  5. 05HumanObservational studyOther

    In children treated with desmopressin or an alarm, treatment group independently predicted cure at 6 months in multivariate analysis.

    In plain wordsIn children with bedwetting, treatment group was independently linked to cure at 6 months.

    Peptide
    Desmopressin
    Outcome
    Not applicableTreatment group as a predictor of cure
    Study

    n: not reported in source

    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    Dose not stated · sublingual · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    Multivariate analysis revealed treatment group, severity of enuresis and monthly income as independent predictors of cure at 6 months.
    2 context sentences
    Summary · context
    We compared the long-term success of desmopressin sublingual lyophilisate formulation and enuretic alarm therapy in children with primary monosymptomatic nocturnal enuresis, and determined predictive factors for treatment success.
    Summary · context
    A total of 142 children with primary monosymptomatic nocturnal enuresis were randomized to receive treatment consisting of desmopressin or enuretic alarm for 6 months.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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