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Study · Animal study (in vivo) · mouse · 2017

5 results

Effects of exogenous desmopressin on a model of heat stress nephropathy in mice.

Roncal-Jimenez CA, Milagres T, Andres-Hernando A, Kuwabara M, Jensen T, Song Z, Bjornstad P, Garcia GE, Sato Y, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ

American journal of physiology. Renal physiology21 Dec 2016Cited by 32 (Europe PMC)

PMID28003190 (opens in a new tab)PMCIDPMC5374310 (opens in a new tab)DOI10.1152/ajprenal.00495.2016 (opens in a new tab)PepBankPUB-28003190
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In normal mice, desmopressin induced albuminuria compared with vehicle.

    In plain wordsIn normal mice, desmopressin increased urine albumin compared with vehicle.

    Peptide
    Desmopressin
    Outcome
    IncreaseAlbuminuria in normal mice
    Study

    micen: not reported in source

    male mice
    Comparator
    vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · 5 weeksAs given in this study (mice).

    Source sentences

    Summary
    Desmopressin also induced albuminuria, glomerular changes, and tubulointerstitial fibrosis in normal animals and also exacerbated injury in mice with heat stress nephropathy.
    2 context sentences
    Summary · context
    Recurrent exposure to heat with limited water availability was performed in male mice over a 5-wk period, with one group receiving desmopressin two times daily and the other group receiving vehicle.
    Summary · context
    Two additional control groups were not exposed to heat or dehydration and received vehicle or desmopressin.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In normal mice, desmopressin induced glomerular changes compared with vehicle.

    In plain wordsIn normal mice, desmopressin caused kidney filtering-structure changes compared with vehicle.

    Peptide
    Desmopressin
    Outcome
    IncreaseGlomerular changes in normal mice
    Study

    micen: not reported in source

    male mice
    Comparator
    vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · 5 weeksAs given in this study (mice).

    Source sentences

    Summary
    Desmopressin also induced albuminuria, glomerular changes, and tubulointerstitial fibrosis in normal animals and also exacerbated injury in mice with heat stress nephropathy.
    2 context sentences
    Summary · context
    Recurrent exposure to heat with limited water availability was performed in male mice over a 5-wk period, with one group receiving desmopressin two times daily and the other group receiving vehicle.
    Summary · context
    Two additional control groups were not exposed to heat or dehydration and received vehicle or desmopressin.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In normal mice, desmopressin induced tubulointerstitial fibrosis compared with vehicle.

    In plain wordsIn normal mice, desmopressin increased kidney tissue scarring compared with vehicle.

    Peptide
    Desmopressin
    Outcome
    IncreaseTubulointerstitial fibrosis in normal mice
    Study

    micen: not reported in source

    male mice
    Comparator
    vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · 5 weeksAs given in this study (mice).

    Source sentences

    Summary
    Desmopressin also induced albuminuria, glomerular changes, and tubulointerstitial fibrosis in normal animals and also exacerbated injury in mice with heat stress nephropathy.
    2 context sentences
    Summary · context
    Recurrent exposure to heat with limited water availability was performed in male mice over a 5-wk period, with one group receiving desmopressin two times daily and the other group receiving vehicle.
    Summary · context
    Two additional control groups were not exposed to heat or dehydration and received vehicle or desmopressin.
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In mice with heat stress nephropathy, desmopressin exacerbated kidney injury compared with vehicle.

    In plain wordsIn mice with heat-related kidney disease, desmopressin worsened kidney injury compared with vehicle.

    Peptide
    Desmopressin
    Outcome
    IncreaseInjury in heat stress nephropathy
    Study

    micen: not reported in source

    heat stress nephropathy in male mice
    Comparator
    vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · 5 weeksAs given in this study (mice).

    Source sentences

    Summary
    Desmopressin also induced albuminuria, glomerular changes, and tubulointerstitial fibrosis in normal animals and also exacerbated injury in mice with heat stress nephropathy.
    2 context sentences
    Summary · context
    Recurrent exposure to heat with limited water availability was performed in male mice over a 5-wk period, with one group receiving desmopressin two times daily and the other group receiving vehicle.
    Summary · context
    Two additional control groups were not exposed to heat or dehydration and received vehicle or desmopressin.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice, desmopressin was associated with renal cortical polyol pathway activation, also reported with heat stress.

    In plain wordsIn mice, desmopressin was linked to activation of a kidney sugar-processing pathway, also seen with heat stress.

    Peptide
    Desmopressin
    Outcome
    IncreaseRenal cortical polyol pathway activation
    Study

    micen: not reported in source

    male mice
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated · 5 weeksAs given in this study (mice).

    Source sentences

    Summary
    Both heat stress and/or desmopressin were also associated with activation of the polyol pathway in the renal cortex, likely due to increased interstitial osmolarity.
    2 context sentences
    Summary · context
    Recurrent exposure to heat with limited water availability was performed in male mice over a 5-wk period, with one group receiving desmopressin two times daily and the other group receiving vehicle.
    Summary · context
    Two additional control groups were not exposed to heat or dehydration and received vehicle or desmopressin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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