Comparing alarms, desmopressin, and combined treatment in Chinese enuretic children.

Fai-Ngo Ng C, Wong SN

Pediatric nephrology (Berlin, Germany)17 Dec 2004Cited by 22 (Europe PMC)

PMID15605283DOI10.1007/s00467-004-1708-5PepBankPUB-15605283

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. 11 results from people.

01HumanRandomized controlled trialEfficacy outcome
In Chinese enuretic children, wetting frequency decreased 52% with desmopressin versus 46% with alarms during treatment.
In plain wordsIn Chinese enuretic children, wetting frequency decreased 52% with desmopressin versus 46% with alarms.
Peptide
Desmopressin
Outcome
DecreaseWetting frequency
Study
n = 73
Comparator
Enuresis alarms
Outcome group
Urinary continence and bladder function · Kidney and urinary
Studied dose
400 mug · oral · 12 weeksAs given in this study (human).
Measurements
Decrease in wetting frequency during treatment
52%
Oral desmopressin 400 mug, group 2
Decrease in wetting frequency during treatment
46%
Alarms, group 1
Source sentences
Summary
The wetting frequency decreased during treatment by 46%, 52%, and 73% in groups 1, 2, and 3, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this multicenter randomized controlled trial was to compare the efficacy of enuresis alarms, oral desmopressin, and combined treatment in Chinese children with monosymptomatic primary nocturnal enuresis.
Summary · context
We assigned 105 children aged 7-15 years to receive alarms (group 1, 35 patients), oral desmopressin 400 mug (group 2, 38 patients), or combined therapy (group 3, 32 patients) for 12 weeks; patients were then followed for 12 weeks after treatment.
Report a problemFND-1560528301
02HumanRandomized controlled trialEfficacy outcome
In Chinese enuretic children, complete response rates were 42% with desmopressin versus 22.9% with alarms.
In plain wordsIn Chinese enuretic children, complete response rates were 42% with desmopressin versus 22.9% with alarms.
Peptide
Desmopressin
Outcome
Not applicableComplete response
Study
n = 73
Comparator
Enuresis alarms
Outcome group
Urinary continence and bladder function · Kidney and urinary
Studied dose
400 mug · oral · 12 weeksAs given in this study (human).
Measurements
Complete response rate
42%
Oral desmopressin, group 2
Complete response rate
22.9%
Alarms, group 1
Source sentences
Summary
The complete and partial response rates were 22.9% and 20%, respectively in group 1, 42% and 10.5% in group 2, and 62.5% and 15.6% in group 3.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this multicenter randomized controlled trial was to compare the efficacy of enuresis alarms, oral desmopressin, and combined treatment in Chinese children with monosymptomatic primary nocturnal enuresis.
Summary · context
We assigned 105 children aged 7-15 years to receive alarms (group 1, 35 patients), oral desmopressin 400 mug (group 2, 38 patients), or combined therapy (group 3, 32 patients) for 12 weeks; patients were then followed for 12 weeks after treatment.
Report a problemFND-1560528303
03HumanRandomized controlled trialEfficacy outcome
In Chinese enuretic children, partial response rates were 10.5% with desmopressin versus 20% with alarms.
In plain wordsIn Chinese enuretic children, partial response rates were 10.5% with desmopressin versus 20% with alarms.
Peptide
Desmopressin
Outcome
Not applicablePartial response
Study
n = 73
Comparator
Enuresis alarms
Outcome group
Urinary continence and bladder function · Kidney and urinary
Studied dose
400 mug · oral · 12 weeksAs given in this study (human).
Measurements
Partial response rate
10.5%
Oral desmopressin, group 2
Partial response rate
20%
Alarms, group 1
Source sentences
Summary
The complete and partial response rates were 22.9% and 20%, respectively in group 1, 42% and 10.5% in group 2, and 62.5% and 15.6% in group 3.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this multicenter randomized controlled trial was to compare the efficacy of enuresis alarms, oral desmopressin, and combined treatment in Chinese children with monosymptomatic primary nocturnal enuresis.
Summary · context
We assigned 105 children aged 7-15 years to receive alarms (group 1, 35 patients), oral desmopressin 400 mug (group 2, 38 patients), or combined therapy (group 3, 32 patients) for 12 weeks; patients were then followed for 12 weeks after treatment.
Report a problemFND-1560528304
04HumanRandomized controlled trialEfficacy outcome
In Chinese enuretic children, wetting frequency decreased 73% with desmopressin plus alarms versus 46% with alarms alone.
In plain wordsIn Chinese enuretic children, wetting frequency decreased 73% with desmopressin plus alarms versus 46% with alarms alone.
Peptide
Desmopressin
Outcome
DecreaseWetting frequency with alarms
Study
n = 67
Comparator
Alarms alone
Outcome group
Urinary continence and bladder function · Kidney and urinary
Studied dose
400 mug · oral · 12 weeksAs given in this study (human).
Measurements
Decrease in wetting frequency during treatment
73%
Desmopressin plus alarms, group 3
Decrease in wetting frequency during treatment
46%
Alarms alone, group 1
Source sentences
Summary
The wetting frequency decreased during treatment by 46%, 52%, and 73% in groups 1, 2, and 3, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this multicenter randomized controlled trial was to compare the efficacy of enuresis alarms, oral desmopressin, and combined treatment in Chinese children with monosymptomatic primary nocturnal enuresis.
Summary · context
We assigned 105 children aged 7-15 years to receive alarms (group 1, 35 patients), oral desmopressin 400 mug (group 2, 38 patients), or combined therapy (group 3, 32 patients) for 12 weeks; patients were then followed for 12 weeks after treatment.
Report a problemFND-1560528307
05HumanRandomized controlled trialEfficacy outcome
In Chinese enuretic children, complete response rates were 62.5% with desmopressin plus alarms versus 22.9% with alarms alone.
In plain wordsIn Chinese enuretic children, complete response rates were 62.5% with desmopressin plus alarms versus 22.9% with alarms alone.
Peptide
Desmopressin
Outcome
IncreaseComplete response with alarms
Study
n = 67
Comparator
Alarms alone
Outcome group
Urinary continence and bladder function · Kidney and urinary
Studied dose
400 mug · oral · 12 weeksAs given in this study (human).
Measurements
Complete response rate
62.5%
Desmopressin plus alarms, group 3
Complete response rate
22.9%
Alarms alone, group 1
Source sentences
Summary
The complete and partial response rates were 22.9% and 20%, respectively in group 1, 42% and 10.5% in group 2, and 62.5% and 15.6% in group 3.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this multicenter randomized controlled trial was to compare the efficacy of enuresis alarms, oral desmopressin, and combined treatment in Chinese children with monosymptomatic primary nocturnal enuresis.
Summary · context
We assigned 105 children aged 7-15 years to receive alarms (group 1, 35 patients), oral desmopressin 400 mug (group 2, 38 patients), or combined therapy (group 3, 32 patients) for 12 weeks; patients were then followed for 12 weeks after treatment.
Report a problemFND-1560528308
06HumanRandomized controlled trialEfficacy outcome
In Chinese enuretic children, partial response rates were 15.6% with desmopressin plus alarms versus 20% with alarms alone.
In plain wordsIn Chinese enuretic children, partial response rates were 15.6% with desmopressin plus alarms versus 20% with alarms alone.
Peptide
Desmopressin
Outcome
DecreasePartial response with alarms
Study
n = 67
Comparator
Alarms alone
Outcome group
Urinary continence and bladder function · Kidney and urinary
Studied dose
400 mug · oral · 12 weeksAs given in this study (human).
Measurements
Partial response rate
15.6%
desmopressin plus alarms (group 3)
Partial response rate
20%
alarms alone (group 1)
Source sentences
Summary
The complete and partial response rates were 22.9% and 20%, respectively in group 1, 42% and 10.5% in group 2, and 62.5% and 15.6% in group 3.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this multicenter randomized controlled trial was to compare the efficacy of enuresis alarms, oral desmopressin, and combined treatment in Chinese children with monosymptomatic primary nocturnal enuresis.
Summary · context
We assigned 105 children aged 7-15 years to receive alarms (group 1, 35 patients), oral desmopressin 400 mug (group 2, 38 patients), or combined therapy (group 3, 32 patients) for 12 weeks; patients were then followed for 12 weeks after treatment.
Report a problemFND-1560528309
07HumanRandomized controlled trialEfficacy outcome
In Chinese enuretic children, desmopressin plus alarms produced a significantly better response than alarms alone by Kaplan-Meier analysis.
In plain wordsIn Chinese enuretic children, desmopressin plus alarms produced a significantly better response than alarms alone.
Peptide
Desmopressin
Outcome
IncreaseTreatment response with alarms
Study
n = 67
Comparator
Alarms alone
Outcome group
Urinary continence and bladder function · Kidney and urinary
Studied dose
400 mug · oral · 12 weeksAs given in this study (human).
Source sentences
Summary
By Kaplan-Meier analysis, group 1 had a significantly poorer response than groups 2 and 3.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this multicenter randomized controlled trial was to compare the efficacy of enuresis alarms, oral desmopressin, and combined treatment in Chinese children with monosymptomatic primary nocturnal enuresis.
Summary · context
We assigned 105 children aged 7-15 years to receive alarms (group 1, 35 patients), oral desmopressin 400 mug (group 2, 38 patients), or combined therapy (group 3, 32 patients) for 12 weeks; patients were then followed for 12 weeks after treatment.
Report a problemFND-1560528310
08HumanRandomized controlled trialEfficacy outcome
In Chinese enuretic children, desmopressin produced a significantly better response than alarms by Kaplan-Meier analysis.
In plain wordsIn Chinese enuretic children, desmopressin produced a significantly better response than alarms.
Peptide
Desmopressin
Outcome
IncreaseTreatment response
Study
n: not reported in source
Comparator
Enuresis alarms
Outcome group
Urinary continence and bladder function · Kidney and urinary
Studied dose
400 mug · oral · 12 weeksAs given in this study (human).
Source sentences
Summary
By Kaplan-Meier analysis, group 1 had a significantly poorer response than groups 2 and 3.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this multicenter randomized controlled trial was to compare the efficacy of enuresis alarms, oral desmopressin, and combined treatment in Chinese children with monosymptomatic primary nocturnal enuresis.
Summary · context
We assigned 105 children aged 7-15 years to receive alarms (group 1, 35 patients), oral desmopressin 400 mug (group 2, 38 patients), or combined therapy (group 3, 32 patients) for 12 weeks; patients were then followed for 12 weeks after treatment.
Report a problemFND-1560528305
09HumanRandomized controlled trialEfficacy outcome
Among Chinese enuretic children who responded, 60% relapsed after desmopressin stopped versus 20% after alarms stopped.
In plain wordsAmong Chinese enuretic children who responded, 60% relapsed after desmopressin stopped versus 20% after alarms stopped.
Peptide
Desmopressin
Outcome
Not applicableRelapse among responders
Study
n: not reported in source
Comparator
Enuresis alarms
Outcome group
Urinary continence and bladder function · Kidney and urinary
Studied dose
400 mug · oral · 12 weeksAs given in this study (human).
Measurements
Relapse among responders
60%
Oral desmopressin, group 2
Relapse among responders
20%
Alarms, group 1
Source sentences
Summary
Of the responders, 20%, 60%, and 40% in groups 1, 2, and 3, respectively, relapsed after stopping treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this multicenter randomized controlled trial was to compare the efficacy of enuresis alarms, oral desmopressin, and combined treatment in Chinese children with monosymptomatic primary nocturnal enuresis.
Summary · context
We assigned 105 children aged 7-15 years to receive alarms (group 1, 35 patients), oral desmopressin 400 mug (group 2, 38 patients), or combined therapy (group 3, 32 patients) for 12 weeks; patients were then followed for 12 weeks after treatment.
Report a problemFND-1560528306
10HumanRandomized controlled trialEfficacy outcome
Among Chinese enuretic responders, 40% relapsed after desmopressin plus alarms stopped versus 20% after alarms alone stopped.
In plain wordsAmong Chinese enuretic responders, 40% relapsed after desmopressin plus alarms stopped versus 20% after alarms alone stopped.
Peptide
Desmopressin
Outcome
IncreaseRelapse among responders with alarms
Study
n: not reported in source
Comparator
Alarms alone
Outcome group
Urinary continence and bladder function · Kidney and urinary
Studied dose
400 mug · oral · 12 weeksAs given in this study (human).
Measurements
Relapse among responders
40%
desmopressin plus alarms (group 3)
Relapse among responders
20%
alarms alone (group 1)
Source sentences
Summary
Of the responders, 20%, 60%, and 40% in groups 1, 2, and 3, respectively, relapsed after stopping treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this multicenter randomized controlled trial was to compare the efficacy of enuresis alarms, oral desmopressin, and combined treatment in Chinese children with monosymptomatic primary nocturnal enuresis.
Summary · context
We assigned 105 children aged 7-15 years to receive alarms (group 1, 35 patients), oral desmopressin 400 mug (group 2, 38 patients), or combined therapy (group 3, 32 patients) for 12 weeks; patients were then followed for 12 weeks after treatment.
Report a problemFND-1560528311
11HumanNon-randomized trialEfficacy outcome
In Chinese enuretic children, desmopressin showed post-treatment rebound, but significant improvements persisted at 12 weeks.
In plain wordsIn Chinese enuretic children, symptoms rebounded after desmopressin treatment, but significant improvements persisted at 12 weeks.
Peptide
Desmopressin
Outcome
MixedPost-treatment rebound
Study
n = 38
Outcome group
Urinary continence and bladder function · Kidney and urinary
Studied dose
400 mug · oral · 12 weeksAs given in this study (human).
Source sentences
Summary
In groups 2 and 3, but not in group 1, there was rebound post treatment, but significant improvements persisted at 12 weeks.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this multicenter randomized controlled trial was to compare the efficacy of enuresis alarms, oral desmopressin, and combined treatment in Chinese children with monosymptomatic primary nocturnal enuresis.
Summary · context
We assigned 105 children aged 7-15 years to receive alarms (group 1, 35 patients), oral desmopressin 400 mug (group 2, 38 patients), or combined therapy (group 3, 32 patients) for 12 weeks; patients were then followed for 12 weeks after treatment.
Report a problemFND-1560528302

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

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