Skip to content

Study · Animal study (in vivo) · guinea pig · 2004

6 results

Transdermal delivery of desmopressin using a coated microneedle array patch system.

Cormier M, Johnson B, Ameri M, Nyam K, Libiran L, Zhang DD, Daddona P

Journal of controlled release : official journal of the Controlled Release Society1 Jul 2004Cited by 231 (Europe PMC)

PMID15212882 (opens in a new tab)DOI10.1016/j.jconrel.2004.04.003 (opens in a new tab)PepBankPUB-15212882
Publisher pagePubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In hairless guinea pigs, desmopressin-coated microneedle arrays delivered pharmacologically relevant amounts after 5 min.

    In plain wordsIn hairless guinea pigs, desmopressin-coated microneedle arrays delivered pharmacologically relevant amounts after 5 min.

    Peptide
    Desmopressin
    Outcome
    Not applicableDelivery after patch application
    Study

    guinea pign: not reported in source

    Hairless guinea pigs
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · transdermal · 5 minAs given in this study (guinea pig).

    Source sentences

    Summary
    Pharmacologically relevant amounts of desmopressin were delivered after 5 min.
    1 context sentence
    Summary · context
    The tips of microneedles in 2-cm2 arrays were covered with a solid coating of various amounts of desmopressin and applied to the skin of hairless guinea pigs for 5 or 15 min.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In hairless guinea pigs, desmopressin-coated microneedle arrays gave bioavailability as high as 85%, with 30% variability.

    In plain wordsIn hairless guinea pigs, desmopressin-coated microneedle arrays gave bioavailability as high as 85%, with 30% variability.

    Peptide
    Desmopressin
    Outcome
    Not applicableBioavailability
    Study

    guinea pign: not reported in source

    Hairless guinea pigs
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · transdermalAs given in this study (guinea pig).

    Measurements

    Bioavailability
    ≤ 85%
    maximum reported
    Variability
    30%

    Source sentences

    Summary
    Bioavailability was as high as 85% and showed acceptable variability (30%).
    1 context sentence
    Summary · context
    The tips of microneedles in 2-cm2 arrays were covered with a solid coating of various amounts of desmopressin and applied to the skin of hairless guinea pigs for 5 or 15 min.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In hairless guinea pigs, serum desmopressin peaked at 60 min after delivery from desmopressin-coated microneedle arrays.

    In plain wordsIn hairless guinea pigs, serum desmopressin peaked at 60 min after delivery from desmopressin-coated microneedle arrays.

    Peptide
    Desmopressin
    Outcome
    Not applicableTime to peak serum concentration
    Study

    guinea pign: not reported in source

    Hairless guinea pigs
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · transdermalAs given in this study (guinea pig).

    Measurements

    Tmax
    60 min

    Source sentences

    Summary
    Immunoreactive serum desmopressin reached peak levels after a Tmax of 60 min.
    1 context sentence
    Summary · context
    The tips of microneedles in 2-cm2 arrays were covered with a solid coating of various amounts of desmopressin and applied to the skin of hairless guinea pigs for 5 or 15 min.
  4. 04AnimalAnimal study (in vivo)Pharmacokinetics

    In hairless guinea pigs, only 10% of the dose from desmopressin-coated microneedle arrays remained on the skin surface after application.

    In plain wordsIn hairless guinea pigs, only 10% of the dose from desmopressin-coated microneedle arrays remained on the skin surface after application.

    Peptide
    Desmopressin
    Outcome
    Not applicableDose remaining on skin surface
    Study

    guinea pign: not reported in source

    Hairless guinea pigs
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · transdermalAs given in this study (guinea pig).

    Measurements

    Dose on skin
    10%
    loaded dose

    Source sentences

    Summary
    Only 10% of the desmopressin dose loaded onto the microneedle array was found on the skin surface after application.
    1 context sentence
    Summary · context
    The tips of microneedles in 2-cm2 arrays were covered with a solid coating of various amounts of desmopressin and applied to the skin of hairless guinea pigs for 5 or 15 min.
  5. 05AnimalAnimal study (in vivo)Safety outcome

    In hairless guinea pigs, desmopressin-coated microneedle patches were well tolerated.

    In plain wordsIn hairless guinea pigs, desmopressin-coated microneedle patches were well tolerated.

    Peptide
    Desmopressin
    Outcome
    Not applicablePatch tolerability
    Study

    guinea pign: not reported in source

    Hairless guinea pigs
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated · transdermalAs given in this study (guinea pig).

    Source sentences

    Summary
    Additionally, the patches were well tolerated.
    1 context sentence
    Summary · context
    The tips of microneedles in 2-cm2 arrays were covered with a solid coating of various amounts of desmopressin and applied to the skin of hairless guinea pigs for 5 or 15 min.

Studies that did not test the peptide alone1

In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Desmopressin.

  1. 06AnimalNot a test of Desmopressin aloneAnimal study (in vivo)Pharmacokinetics

    In hairless guinea pigs, elimination kinetics were similar after desmopressin-coated microneedle array delivery and intravenous desmopressin.

    In plain wordsIn hairless guinea pigs, elimination kinetics were similar after desmopressin-coated microneedle array delivery and intravenous desmopressin.

    Peptide
    Desmopressin
    Outcome
    Direction not reportedElimination kinetics
    Study

    guinea pign: not reported in source

    Hairless guinea pigs
    Comparator
    Intravenous delivery
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Elimination kinetics for serum desmopressin was similar after transdermal and intravenous (IV) delivery, suggesting the absence of a skin depot.
    1 context sentence
    Summary · context
    The tips of microneedles in 2-cm2 arrays were covered with a solid coating of various amounts of desmopressin and applied to the skin of hairless guinea pigs for 5 or 15 min.

    In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.