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Study · Randomized controlled trial · n = 93 · 2001

3 results

Efficacy of desmopressin combined with alarm therapy for monosymptomatic nocturnal enuresis.

Leebeek-Groenewegen A, Blom J, Sukhai R, Van Der Heijden B

The Journal of urology1 Dec 2001Cited by 37 (Europe PMC)

PMID11696811 (opens in a new tab)DOI10.1016/s0022-5347(05)65615-7 (opens in a new tab)PepBankPUB-11696811
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In children with enuresis, desmopressin added to alarm therapy reduced wet nights more than alarm therapy plus placebo after 3 weeks.

    In plain wordsIn children with enuresis, desmopressin plus alarm therapy reduced wet nights more than alarm therapy plus placebo after 3 weeks.

    Peptide
    Desmopressin
    Outcome
    DecreaseWet nights after three weeks
    Study

    n = 93

    Comparator
    Alarm therapy plus placebo
    Outcome group
    Enuresis · Kidney and urinary
    Studied dose
    40 microg for 3 weeks then 20 microg for 3 weeks · intranasal · 6 weeksAs given in this study (human).

    Source sentences

    Summary
    A significantly greater reduction in the number of wet nights was observed after the first 3 weeks of treatment in group 1.
    2 context sentences
    Summary · context
    Of 93 patients 47 were randomized to receive alarm therapy and 40 microg. intranasal desmopressin for 3 weeks followed by 20 microg. desmopressin for 3 weeks (group 1) and 46 received alarm therapy and placebo (group 2).
    Summary · context
    After 6 weeks on alarm therapy and medication or placebo, both groups received an additional 3 weeks of alarm monotherapy.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In children with enuresis, long-term bed-wetting frequency did not differ significantly between desmopressin plus alarm therapy and alarm therapy plus placebo.

    In plain wordsIn children with enuresis, long-term bed-wetting frequency did not differ significantly between desmopressin plus alarm therapy and alarm therapy plus placebo.

    Peptide
    Desmopressin
    Outcome
    No significant changeLong-term bed-wetting frequency
    Study

    n = 93

    Comparator
    Alarm therapy plus placebo
    Outcome group
    Enuresis · Kidney and urinary
    Studied dose
    40 microg for 3 weeks then 20 microg for 3 weeks · intranasal · 6 weeksAs given in this study (human).

    Source sentences

    Summary
    However, after long-term followup no significant differences in bed-wetting frequency were noted.
    2 context sentences
    Summary · context
    Of 93 patients 47 were randomized to receive alarm therapy and 40 microg. intranasal desmopressin for 3 weeks followed by 20 microg. desmopressin for 3 weeks (group 1) and 46 received alarm therapy and placebo (group 2).
    Summary · context
    After 6 weeks on alarm therapy and medication or placebo, both groups received an additional 3 weeks of alarm monotherapy.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In children with enuresis, long-term success rates were 36% to 37% for desmopressin plus alarm therapy and alarm therapy plus placebo.

    In plain wordsIn children with enuresis, long-term success rates were 36% to 37% with desmopressin plus alarm therapy or alarm therapy plus placebo.

    Peptide
    Desmopressin
    Outcome
    Not applicableLong-term success
    Study

    n = 93

    Comparator
    Alarm therapy plus placebo
    Outcome group
    Enuresis · Kidney and urinary
    Studied dose
    40 microg for 3 weeks then 20 microg for 3 weeks · intranasal · 6 weeksAs given in this study (human).

    Measurements

    Long-term success rate
    36 to 37%
    both treatment modalities, long-term follow-up

    Source sentences

    Summary
    However, both treatment modalities have a low long-term success rate of 36% to 37%.
    2 context sentences
    Summary · context
    Of 93 patients 47 were randomized to receive alarm therapy and 40 microg. intranasal desmopressin for 3 weeks followed by 20 microg. desmopressin for 3 weeks (group 1) and 46 received alarm therapy and placebo (group 2).
    Summary · context
    After 6 weeks on alarm therapy and medication or placebo, both groups received an additional 3 weeks of alarm monotherapy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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