In children with monosymptomatic enuresis, relapse was similar after structured versus abrupt desmopressin withdrawal, 47.83% versus 45.83%.
In plain wordsIn children with bedwetting, gradual desmopressin withdrawal did not reduce relapse compared with abrupt withdrawal.
- Peptide
- Desmopressin
- Outcome
- No significant changeRelapse one month after withdrawal
- Study
n: not reported in source
- Comparator
- abrupt desmopressin withdrawal
- Analysis
- Primary
- Outcome group
- Urinary continence and bladder function · Kidney and urinary
- Studied dose
- 120 mcg/day, then 60 mcg/day for 15 days and 60 mcg every second evening for 15 days · sublingual · 3 months before withdrawalAs given in this study (human).
Measurements
- Relapse
- 47.83%
- structured withdrawal
- Relapse
- 45.83%
- abrupt withdrawal
- P value
- 0.89 unitless
- reported result
Source sentences
Relapse rate at 1 month after the end of treatment was 47.83% in the group on a structured program versus 45.83% in the abrupt termination group (p = 0.89).
3 context sentences(design, population, supporting numbers)
Eighty-one children, aged between 5½ and 14 years (mean age 8.64 years), were treated with MELT at a dosage of 120 mcg a day.
Responders were randomized to been withdrawn from therapy, after 3 months, abruptly or in a structured withdrawal program (60 mcg/day for 15 days and then 60 mcg every second evening for another 15 days).
Main outcome parameter was relapse rate 1 month after the end of treatment.