Desmopressin does not decrease blood loss and transfusion requirements in patients undergoing hepatectomy.

Wong AY, Irwin MG, Hui TW, Fung SK, Fan ST, Ma ES

Canadian journal of anaesthesia = Journal canadien d'anesthesie1 Jan 2003Cited by 39 (Europe PMC)

PMID12514144DOI10.1007/bf03020180PepBankPUB-12514144

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

01HumanRandomized controlled trialEfficacy outcome
In hepatectomy patients, intraoperative blood loss ranged from 400-7128 mL, with no significant difference between desmopressin and saline.
In plain wordsIn hepatectomy patients, desmopressin did not significantly change intraoperative blood loss compared with saline.
Peptide
Desmopressin
Outcome
No significant changeIntraoperative blood loss
Study
n = 59
Comparator
Normal saline
Outcome group
Bleeding · Cardiovascular
Studied dose
0.3 micro g x kg(-1) · intravenous · 20 minAs given in this study (human).
Measurements
Intraoperative blood loss
400 to 7128 mL
study range
Source sentences
Summary
A large range of intraoperative blood loss (400-7128 mL) was observed, with no significant differences between groups.
2 context sentences(design, population, supporting numbers)
Summary · context
To determine the effects of desmopressin on coagulation and blood loss in patients undergoing elective partial hepatectomy.
Summary · context
A randomized, controlled and double-blind study on 59 patients who received either 0.3 micro g x kg(-1) of desmopressin or an equal volume of normal saline (control) infused intravenously over 20 min after induction of general anesthesia.
Report a problemFND-1251414402
02HumanRandomized controlled trialEfficacy outcome
In hepatectomy patients, transfusion requirements were similar with desmopressin and saline.
In plain wordsIn hepatectomy patients, transfusion requirements were similar with desmopressin and saline.
Peptide
Desmopressin
Outcome
Direction not reportedTransfusion requirements
Study
n = 59
Comparator
Normal saline
Outcome group
Transfusion · Cardiovascular
Studied dose
0.3 micro g x kg(-1) · intravenous · 20 minAs given in this study (human).
Source sentences
Summary
Transfusion requirements were similar in both groups.
2 context sentences(design, population, supporting numbers)
Summary · context
To determine the effects of desmopressin on coagulation and blood loss in patients undergoing elective partial hepatectomy.
Summary · context
A randomized, controlled and double-blind study on 59 patients who received either 0.3 micro g x kg(-1) of desmopressin or an equal volume of normal saline (control) infused intravenously over 20 min after induction of general anesthesia.
Report a problemFND-1251414405
03HumanNon-randomized trialEfficacy outcome
In hepatectomy patients, activated partial thromboplastin time shortened in the desmopressin group.
In plain wordsIn hepatectomy patients, activated partial thromboplastin time shortened in the desmopressin group.
Peptide
Desmopressin
Outcome
DecreaseActivated partial thromboplastin time
Study
n = 59
Outcome group
Bleeding and clotting · Cardiovascular
Studied dose
0.3 micro g x kg(-1) · intravenous · 20 minAs given in this study (human).
Measurements
P value
0.02
APTT shortened in Group D, PT prolonged in Group C (same sentence)
Source sentences
Summary
The activated partial thromboplastin time was shortened in Group D whereas prothrombin time was prolonged in Group C; (P = 0.02).
2 context sentences(design, population, supporting numbers)
Summary · context
To determine the effects of desmopressin on coagulation and blood loss in patients undergoing elective partial hepatectomy.
Summary · context
A randomized, controlled and double-blind study on 59 patients who received either 0.3 micro g x kg(-1) of desmopressin or an equal volume of normal saline (control) infused intravenously over 20 min after induction of general anesthesia.
Report a problemFND-1251414401
04HumanNon-randomized trialSafety outcome
In hepatectomy patients, the study reported no changes in plasma electrolyte levels with desmopressin or saline.
In plain wordsIn hepatectomy patients, the study reported no changes in plasma electrolyte levels with desmopressin or saline.
Peptide
Desmopressin
Outcome
No significant changePlasma electrolyte levels
Study
n = 59
Outcome group
Adverse events · Metabolic and weight
Studied dose
0.3 micro g x kg(-1) · intravenous · 20 minAs given in this study (human).
Source sentences
Summary
There were no changes in plasma electrolyte levels or osmolality.
2 context sentences(design, population, supporting numbers)
Summary · context
To determine the effects of desmopressin on coagulation and blood loss in patients undergoing elective partial hepatectomy.
Summary · context
A randomized, controlled and double-blind study on 59 patients who received either 0.3 micro g x kg(-1) of desmopressin or an equal volume of normal saline (control) infused intravenously over 20 min after induction of general anesthesia.
Report a problemFND-1251414403
05HumanNon-randomized trialSafety outcome
In hepatectomy patients, the study reported no changes in plasma osmolality with desmopressin or saline.
In plain wordsIn hepatectomy patients, the study reported no changes in plasma osmolality with desmopressin or saline.
Peptide
Desmopressin
Outcome
No significant changePlasma osmolality
Study
n = 59
Outcome group
Adverse events · Metabolic and weight
Studied dose
0.3 micro g x kg(-1) · intravenous · 20 minAs given in this study (human).
Source sentences
Summary
There were no changes in plasma electrolyte levels or osmolality.
2 context sentences(design, population, supporting numbers)
Summary · context
To determine the effects of desmopressin on coagulation and blood loss in patients undergoing elective partial hepatectomy.
Summary · context
A randomized, controlled and double-blind study on 59 patients who received either 0.3 micro g x kg(-1) of desmopressin or an equal volume of normal saline (control) infused intravenously over 20 min after induction of general anesthesia.
Report a problemFND-1251414404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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