ACTH and cortisol release following intravenous desmopressin: a dose-response study.

Scott LV, Medbak S, Dinan TG

Clinical endocrinology1 Nov 1999Cited by 30 (Europe PMC)

PMID10594528DOI10.1046/j.1365-2265.1999.00850.xPepBankPUB-10594528

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

01HumanNon-randomized trialActivity measurement
After 10microg DDAVP, 11/18 subjects were responders based on ACTH and cortisol output.
In plain wordsAfter desmopressin, 11/18 subjects responded based on ACTH and cortisol output.
Peptide
Desmopressin
Outcome
Not applicableCombined ACTH and cortisol responders
Study
n = 18
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
10 microg · intravenous bolusAs given in this study (human).
Measurements
Subjects deemed responders
11 subjects
of 18 subjects after 10 microg DDAVP, ACTH and cortisol output
Source sentences
Summary
11/18 subjects were deemed 'responders' following 10microg DDAVP on the basis of both ACTH and cortisol output.
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 18 subjects participated in the study.
Summary · context
Saline, 5 microg, 10 microg and 15 microg DDAVP were administered as an intravenous bolus at 1300 h
Summary · context
Plasma ACTH and cortisol responses were measured over a 120-minutes period.
Report a problemFND-1059452807
02HumanNon-randomized trialActivity measurement
In human subjects, 5 microg DDAVP significantly increased ACTH response versus saline.
In plain wordsIn human subjects, 5 microg desmopressin increased ACTH response compared with saline.
Peptide
Desmopressin
Outcome
IncreaseACTH response at 5 microg
Study
n: not reported in source
Comparator
Saline
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
5 microg · intravenous bolusAs given in this study (human).
Source sentences
Summary
The ACTH response to 5, 10 and 15 microg DDAVP was significantly greater than saline at all three doses, whilst maximal responses were seen at 10 microg.
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 18 subjects participated in the study.
Summary · context
Saline, 5 microg, 10 microg and 15 microg DDAVP were administered as an intravenous bolus at 1300 h
Summary · context
Plasma ACTH and cortisol responses were measured over a 120-minutes period.
Report a problemFND-1059452801
03HumanNon-randomized trialActivity measurement
In human subjects, 10 microg DDAVP significantly increased ACTH response versus saline and produced the maximal response.
In plain wordsIn human subjects, 10 microg desmopressin increased ACTH response compared with saline and produced the largest response.
Peptide
Desmopressin
Outcome
IncreaseACTH response at 10 microg
Study
n: not reported in source
Comparator
Saline
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
10 microg · intravenous bolusAs given in this study (human).
Source sentences
Summary
The ACTH response to 5, 10 and 15 microg DDAVP was significantly greater than saline at all three doses, whilst maximal responses were seen at 10 microg.
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 18 subjects participated in the study.
Summary · context
Saline, 5 microg, 10 microg and 15 microg DDAVP were administered as an intravenous bolus at 1300 h
Summary · context
Plasma ACTH and cortisol responses were measured over a 120-minutes period.
Report a problemFND-1059452802
04HumanNon-randomized trialActivity measurement
In human subjects, 15 microg DDAVP significantly increased ACTH response versus saline.
In plain wordsIn human subjects, 15 microg desmopressin increased ACTH response compared with saline.
Peptide
Desmopressin
Outcome
IncreaseACTH response at 15 microg
Study
n: not reported in source
Comparator
Saline
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
15 microg · intravenous bolusAs given in this study (human).
Source sentences
Summary
The ACTH response to 5, 10 and 15 microg DDAVP was significantly greater than saline at all three doses, whilst maximal responses were seen at 10 microg.
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 18 subjects participated in the study.
Summary · context
Saline, 5 microg, 10 microg and 15 microg DDAVP were administered as an intravenous bolus at 1300 h
Summary · context
Plasma ACTH and cortisol responses were measured over a 120-minutes period.
Report a problemFND-1059452803
05HumanNon-randomized trialActivity measurement
In human subjects, 5 microg DDAVP did not significantly increase cortisol response versus saline.
In plain wordsIn human subjects, 5 microg desmopressin did not significantly increase cortisol response compared with saline.
Peptide
Desmopressin
Outcome
No significant changeCortisol response at 5 microg
Study
n: not reported in source
Comparator
Saline
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
5 microg · intravenous bolusAs given in this study (human).
Source sentences
Summary
The cortisol responses to 10 and 15 microg DDAVP doses, but not 5 microg, were significantly greater than following saline.
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 18 subjects participated in the study.
Summary · context
Saline, 5 microg, 10 microg and 15 microg DDAVP were administered as an intravenous bolus at 1300 h
Summary · context
Plasma ACTH and cortisol responses were measured over a 120-minutes period.
Report a problemFND-1059452804
06HumanNon-randomized trialActivity measurement
In human subjects, 10 microg DDAVP significantly increased cortisol response versus saline.
In plain wordsIn human subjects, 10 microg desmopressin increased cortisol response compared with saline.
Peptide
Desmopressin
Outcome
IncreaseCortisol response at 10 microg
Study
n: not reported in source
Comparator
Saline
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
10 microg · intravenous bolusAs given in this study (human).
Source sentences
Summary
The cortisol responses to 10 and 15 microg DDAVP doses, but not 5 microg, were significantly greater than following saline.
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 18 subjects participated in the study.
Summary · context
Saline, 5 microg, 10 microg and 15 microg DDAVP were administered as an intravenous bolus at 1300 h
Summary · context
Plasma ACTH and cortisol responses were measured over a 120-minutes period.
Report a problemFND-1059452805
07HumanNon-randomized trialActivity measurement
In human subjects, 15 microg DDAVP significantly increased cortisol response versus saline.
In plain wordsIn human subjects, 15 microg desmopressin increased cortisol response compared with saline.
Peptide
Desmopressin
Outcome
IncreaseCortisol response at 15 microg
Study
n: not reported in source
Comparator
Saline
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
15 microg · intravenous bolusAs given in this study (human).
Source sentences
Summary
The cortisol responses to 10 and 15 microg DDAVP doses, but not 5 microg, were significantly greater than following saline.
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 18 subjects participated in the study.
Summary · context
Saline, 5 microg, 10 microg and 15 microg DDAVP were administered as an intravenous bolus at 1300 h
Summary · context
Plasma ACTH and cortisol responses were measured over a 120-minutes period.
Report a problemFND-1059452806

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.