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Study · Randomized controlled trial · n = 95 · 1993

3 results

Desmopressin does not decrease bleeding after cardiac operation in young children.

Reynolds LM, Nicolson SC, Jobes DR, Steven JM, Norwood WI, McGonigle ME, Manno CS

The Journal of thoracic and cardiovascular surgery1 Dec 1993Cited by 38 (Europe PMC)

PMID8246577 (opens in a new tab)DOI10.1016/s0022-5223(19)33965-0 (opens in a new tab)PepBankPUB-08246577
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In children after cardiac surgery, blood loss did not differ with desmopressin versus placebo, 30 +/- 33 versus 35 +/- 36 ml/kg.

    In plain wordsIn children after cardiac surgery, desmopressin did not reduce blood loss compared with placebo.

    Peptide
    Desmopressin
    Outcome
    No significant changeBlood loss over 24 hours
    Study

    n = 95

    Comparator
    Saline placebo
    Outcome group
    Blood Loss · Cardiovascular
    Studied dose
    0.3 microgram/kgAs given in this study (human).

    Measurements

    Blood loss
    30 ml/kg
    desmopressin mean
    Blood loss
    35 ml/kg
    placebo mean

    Source sentences

    Summary
    Twenty-four-hour blood loss and replacement between the desmopressin and placebo groups were not different (blood loss: desmopressin 30 +/- 33 ml/kg, placebo 35 +/- 36; blood replacement: desmopressin 65 +/- 43 ml/kg, placebo 64 +/- 46 ml/kg).
    2 context sentences
    Summary · context
    The study consisted of a randomized, blinded comparison of 112 pediatric patients who received either desmopressin 0.3 microgram/kg or saline solution placebo after cardiopulmonary bypass.
    Summary · context
    Data collection was completed for 95 patients.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In children after cardiac surgery, blood replacement did not differ with desmopressin versus placebo, 65 +/- 43 versus 64 +/- 46 ml/kg.

    In plain wordsIn children after cardiac surgery, desmopressin did not reduce blood replacement compared with placebo.

    Peptide
    Desmopressin
    Outcome
    No significant changeBlood replacement over 24 hours
    Study

    n = 95

    Comparator
    Saline placebo
    Outcome group
    Blood Transfusion · Cardiovascular
    Studied dose
    0.3 microgram/kgAs given in this study (human).

    Measurements

    Blood replacement
    65 ml/kg
    desmopressin mean
    Blood replacement
    64 ml/kg
    placebo mean

    Source sentences

    Summary
    Twenty-four-hour blood loss and replacement between the desmopressin and placebo groups were not different (blood loss: desmopressin 30 +/- 33 ml/kg, placebo 35 +/- 36; blood replacement: desmopressin 65 +/- 43 ml/kg, placebo 64 +/- 46 ml/kg).
    2 context sentences
    Summary · context
    The study consisted of a randomized, blinded comparison of 112 pediatric patients who received either desmopressin 0.3 microgram/kg or saline solution placebo after cardiopulmonary bypass.
    Summary · context
    Data collection was completed for 95 patients.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In children after cardiac surgery, coagulation profiles did not differ between desmopressin and placebo at any measured time.

    In plain wordsIn children after cardiac surgery, clotting profiles did not differ between desmopressin and placebo.

    Peptide
    Desmopressin
    Outcome
    No significant changeCoagulation profiles
    Study

    n = 95

    Comparator
    Saline placebo
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    0.3 microgram/kgAs given in this study (human).

    Source sentences

    Summary
    Coagulation profiles between the desmopressin and placebo groups were not different at any time.
    2 context sentences
    Summary · context
    The study consisted of a randomized, blinded comparison of 112 pediatric patients who received either desmopressin 0.3 microgram/kg or saline solution placebo after cardiopulmonary bypass.
    Summary · context
    Data collection was completed for 95 patients.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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