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Study · Randomized controlled trial · n = 44 · 1994

3 results

Use of desmopressin acetate to reduce blood transfusion requirements during cardiac surgery in patients with acetylsalicylic-acid-induced platelet dysfunction.

Sheridan DP, Card RT, Pinilla JC, Harding SM, Thomson DJ, Gauthier L, Drotar D

Canadian journal of surgery. Journal canadien de chirurgie1 Feb 1994Cited by 36 (Europe PMC)

PMID8306217 (opens in a new tab)PepBankPUB-08306217
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In aspirin-exposed coronary bypass patients, DDAVP reduced blood loss to 1543 mL versus 2376 mL with placebo.

    In plain wordsIn aspirin-exposed coronary bypass patients, DDAVP reduced blood loss compared with placebo.

    Peptide
    Desmopressin
    Outcome
    DecreaseBlood loss
    Study

    n = 44

    Comparator
    Placebo
    Outcome group
    Blood Loss · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    Blood loss
    1543 mL
    DDAVP
    Blood loss
    2376 mL
    placebo

    Source sentences

    Summary
    Patients treated with DDAVP lost significantly (p < 0.01) less blood than those receiving a placebo (1543 mL versus 2376 mL respectively).
    3 context sentences
    Summary · context
    A randomized, double-blind, placebo controlled study.
    Summary · context
    Men under the age of 70 years who had taken acetylsalicylic acid within 7 days of scheduled coronary artery bypass surgery.
    Summary · context
    Forty-four patients were randomized with restriction in blocks of 10; 20 received DDAVP and 24 received a placebo.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In aspirin-exposed coronary bypass patients, 19 patients lost more than 2000 mL of blood, and 15 of them were in the placebo group, so fewer DDAVP recipients had this loss.

    In plain wordsIn aspirin-exposed coronary bypass patients, blood loss above 2000 mL occurred less often with DDAVP than with placebo.

    Peptide
    Desmopressin
    Outcome
    DecreaseBlood loss above 2000 mL
    Study

    n = 44

    Comparator
    Placebo
    Outcome group
    Blood Loss · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    Patients with blood loss above 2000 mL
    19 patients
    both groups
    Patients with blood loss above 2000 mL
    15 patients
    placebo

    Source sentences

    Summary
    Nineteen patients had a blood loss of more than 2000 mL; 15 of these were in the placebo group.
    3 context sentences
    Summary · context
    A randomized, double-blind, placebo controlled study.
    Summary · context
    Men under the age of 70 years who had taken acetylsalicylic acid within 7 days of scheduled coronary artery bypass surgery.
    Summary · context
    Forty-four patients were randomized with restriction in blocks of 10; 20 received DDAVP and 24 received a placebo.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In aspirin-exposed coronary bypass patients, fewer DDAVP recipients required transfusion than placebo recipients, 9 versus 18.

    In plain wordsIn aspirin-exposed coronary bypass patients, fewer patients needed transfusion with DDAVP than with placebo.

    Peptide
    Desmopressin
    Outcome
    DecreasePatients requiring transfusion
    Study

    n = 44

    Comparator
    Placebo
    Outcome group
    Blood Transfusion · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    Patients requiring transfusion
    9 patients
    DDAVP
    Patients requiring transfusion
    18 patients
    placebo

    Source sentences

    Summary
    Significantly (p < 0.02) fewer patients receiving DDAVP required blood transfusion (9 versus 18).
    3 context sentences
    Summary · context
    A randomized, double-blind, placebo controlled study.
    Summary · context
    Men under the age of 70 years who had taken acetylsalicylic acid within 7 days of scheduled coronary artery bypass surgery.
    Summary · context
    Forty-four patients were randomized with restriction in blocks of 10; 20 received DDAVP and 24 received a placebo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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